Drugs in Pregnancy and Lactation, 2nd Edition
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Clinical Pharmaceutics".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1512
Special Issue Editors
2. Department of Clinical Pharmacology, Department of Laboratory Medicine, University Hospital Ostrava, 708 52 Ostrava, Czech Republic
Interests: therapeutic drug monitoring; pregnancy; breastfeeding; antiepileptic drugs; multiple sclerosis
Special Issues, Collections and Topics in MDPI journals
Interests: therapeutic drug monitoring; clinical pharmacology; personalised medicine; drug metabolism; drug safety; pharmacodynamics; drug toxicity; multiplex sclerosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Women frequently take a variety of drugs during pregnancy and lactation, including prescription and over-the-counter drugs, as well as herbal agents. It is well-known that pregnancy induces significant changes in both pharmacokinetics and pharmacodynamics of most drugs with a high intra- and interpatient variability. Unfortunately, data on long-term safety of the prenatal and breastfeeding-exposed infants are still lacking for many drugs. For this reason, most medications do not include labelling information about their use during pregnancy and lactation. Choosing the appropriate drug dose for a pregnant and nursing woman is a difficult balancing act between optimal maternal treatment and minimal risk of harm to the fetuses and/or breastfed infants. Therapeutic drug monitoring may be a useful tool for dose adjustment in this period, and analysis of the umbilical cord/maternal serum drug concentration ratio is the method recommended to assess transplacental transfer. Recognizing pregnant and lactating women as special populations is essential to obtain information about the safety and efficacy of drugs, which is of crucial importance. This Special Issue welcomes the submission of original and review articles.
Dr. Ivana Kacirova
Dr. Milan Grundmann
Guest Editors
Manuscript Submission Information
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Keywords
- contraception/possible infertility related to the drug
- pharmacokinetics during pregnancy and lactation
- fetal and neonatal complications
- intrauterine therapy of fetal diseases
- umbilical cord serum drug concentrations
- drug interaction with placental transporters
- milk and breastfed infant serum drug concentrations
- the need for multidisciplinary teams and the additional complexity of treatment
Related Special Issue
- Drugs in Pregnancy and Lactation in Pharmaceutics (11 articles)
