Advances in ADME for Drug Discovery
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".
Deadline for manuscript submissions: 10 July 2024 | Viewed by 169
Special Issue Editors
Interests: toxicology; analytical toxicology; forensic and clinical toxicology; mass spectrometry; chromatography
Special Issue Information
Dear Colleagues,
Drug discovery investigations require a profound understanding of the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds. The absorption kinetics and fate of a drug in the human body play pivotal roles in determining its efficacy and safety profile. Drug–drug interactions (DDI) further complicate this landscape, potentially altering systemic exposure and introducing unexpected side effects.
Our forthcoming Special Issue aims to delve into the crucial aspects of ADME, shedding light on its significance in contemporary drug discovery. As evidenced by recent research, the identification and development of potential drug candidates involve navigating through various challenges, including pharmacokinetics, drug interactions, and safety considerations. ADME properties have emerged as decisive factors influencing the success or failure of promising bioactive compounds.
This Special Issue invites contributions encompassing diverse methodologies, from in vitro and in vivo experiments to in silico modeling and simulation approaches. We encourage submissions of original and review articles showcasing advancements in drug metabolism and pharmacokinetics (DMPK) and clinical pharmacology, particularly in the evaluation and prediction of DDIs. By exploring these facets, we aim to foster a comprehensive understanding of ADME properties, ultimately facilitating the expedited and effective development of novel therapeutic agents.
We look forward to receiving your contributions.
Prof. Dr. José Luiz Costa
Dr. Natalicia De Jesus Antunes
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmacokinetics
- absorption
- bioavailability
- metabolism
- PBPK modelling
- PK/PD modelling
- drug–drug interaction
