Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.9
5.4
Journals
Pharmaceutics
Special Issues
Functionalized Nanoparticles in Cancer Therapeutics, 2nd Edition
share announcement

Functionalized Nanoparticles in Cancer Therapeutics, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 4306

Special Issue Editors

Prof. Dr. R. Jayachandra Babu

E-Mail Website
Guest Editor
Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA
Interests: nanoparticles; liposomes; solubility improvement; chemotherapeutic delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Amit K. Tiwari

E-Mail Website
Guest Editor
College of Pharmacy, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
Interests: drug resistance; chemotherapy failure; drug–drug interaction; anticancer drug discovery; novel mechanisms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is a leading cause of death, accounting for millions of lives lost worldwide. Drug discovery and development efforts have provided highly potent chemotherapeutic drug molecules for the treatment of various cancers. However, many cancer mortalities are due to high systemic exposures from conventional chemotherapeutic drugs to various organs and inadequate delivery to the tumor sites. Targeted delivery of drugs, via functional nanomedicines to cancer tumors in a “magic bullet” approach, selectively kills the tumor cells without harming the benign cells. Current clinical practice for cancer treatment is based on many functional nanomedicines for tumor targeting with minimal exposure to “normal” cells, thus avoiding toxicity to the patient.

This Special Issue covers the following nanomedicines:

  • Protein, polymer, and lipid-based nanomedicines with multi functionalities such as targeted moieties, triggered stimuli responses, immunoevasion (pegylation), prolonged release, and protection of the drug from degradation;
  • Inorganic nanomedicines with unique electromagnetic properties for tumor site-specific delivery and diagnostic and imaging capabilities;
  • Nanomedicines prepared with various functional biomaterials with unique transport properties for tumor targeting via enhanced permeability and retention (EPR) effect.

Prof. Dr. R. Jayachandra Babu
Dr. Amit K. Tiwari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liposomes
  • polymeric nanoparticles
  • dendrimer-based nanoparticles
  • micellar nanoparticles
  • inorganic nanoparticles
  • small interfering RNA-based nanoparticles
  • protein-based nanoparticles
  • functional nanomaterials

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 1916 KiB  
Article
Efficient Gene Editing for Heart Disease via ELIP-Based CRISPR Delivery System
by Xing Yin, Romain Harmancey, Brion Frierson, Jean G. Wu, Melanie R. Moody, David D. McPherson and Shao-Ling Huang
Pharmaceutics 2024, 16(3), 343; https://doi.org/10.3390/pharmaceutics16030343 - 29 Feb 2024
Viewed by 878
Abstract
Liposomes as carriers for CRISPR/Cas9 complexes represent an attractive approach for cardiovascular gene therapy. A critical barrier to this approach remains the efficient delivery of CRISPR-based genetic materials into cardiomyocytes. Echogenic liposomes (ELIP) containing a fluorescein isothiocyanate-labeled decoy oligodeoxynucleotide against nuclear factor kappa [...] Read more.
Liposomes as carriers for CRISPR/Cas9 complexes represent an attractive approach for cardiovascular gene therapy. A critical barrier to this approach remains the efficient delivery of CRISPR-based genetic materials into cardiomyocytes. Echogenic liposomes (ELIP) containing a fluorescein isothiocyanate-labeled decoy oligodeoxynucleotide against nuclear factor kappa B (ELIP-NF-κB-FITC) were used both in vitro on mouse neonatal ventricular myocytes and in vivo on rat hearts to assess gene delivery efficacy with or without ultrasound. In vitro analysis was then repeated with ELIP containing Cas9-sg-IL1RL1 (interleukin 1 receptor-like 1) RNA to determine the efficiency of gene knockdown. ELIP-NF-κB-FITC without ultrasound showed limited gene delivery in vitro and in vivo, but ultrasound combined with ELIP notably improved penetration into heart cells and tissues. When ELIP was used to deliver Cas9-sg-IL1RL1 RNA, gene editing was successful and enhanced by ultrasound. This innovative approach shows promise for heart disease gene therapy using CRISPR technology. Full article
(This article belongs to the Special Issue Functionalized Nanoparticles in Cancer Therapeutics, 2nd Edition)
►▼ Show Figures

Figure 1

Review

Jump to: Research

18 pages, 1449 KiB  
Review
Role of Biofunctionalized Nanoparticles in Digestive Cancer Vaccine Development
by Razvan Zdrehus, Cristian Delcea and Lucian Mocan
Pharmaceutics 2024, 16(3), 410; https://doi.org/10.3390/pharmaceutics16030410 - 16 Mar 2024
Viewed by 919
Abstract
Nanotechnology has provided an opportunity for unparalleled development of the treatment of various severe diseases. The unique properties of nanoparticles offer a promising strategy for enhancing antitumor immunity by enhancing immunogenicity and presentation of tumor autoantigens for cancer immunotherapy. Polymeric, liposomal, carbon or [...] Read more.
Nanotechnology has provided an opportunity for unparalleled development of the treatment of various severe diseases. The unique properties of nanoparticles offer a promising strategy for enhancing antitumor immunity by enhancing immunogenicity and presentation of tumor autoantigens for cancer immunotherapy. Polymeric, liposomal, carbon or silica-based nanoparticles are among those with major immunomodulatory roles in various cancer treatments. Cancer vaccines, in particular digestive cancer vaccines, have been researched and developed on nanotechnological platforms. Due to their safety, controlled release, targeting of dendritic cells (DCs) and improved antigen uptake, as well as enhanced immunogenicity, nanoparticles have been used as carriers, as adjuvants for increased effect at the tumor level, for their immunomodulating effect, or for targeting the tumor microenvironment, thereby increasing tumor immunogenicity and reducing tumor inflammatory response. This review looks at digestive cancer vaccines developed on nanoparticle platforms and the impact nanoparticles have on the effects of these vaccines. Full article
(This article belongs to the Special Issue Functionalized Nanoparticles in Cancer Therapeutics, 2nd Edition)
►▼ Show Figures

Figure 1

28 pages, 3710 KiB  
Review
Tumor-Associated Macrophage Targeting of Nanomedicines in Cancer Therapy
by Xuejia Kang, Yongzhuo Huang, Huiyuan Wang, Sanika Jadhav, Zongliang Yue, Amit K. Tiwari and R. Jayachandra Babu
Pharmaceutics 2024, 16(1), 61; https://doi.org/10.3390/pharmaceutics16010061 - 29 Dec 2023
Cited by 1 | Viewed by 2112
Abstract
The tumor microenvironment (TME) is pivotal in tumor growth and metastasis, aligning with the “Seed and Soil” theory. Within the TME, tumor-associated macrophages (TAMs) play a central role, profoundly influencing tumor progression. Strategies targeting TAMs have surfaced as potential therapeutic avenues, encompassing interventions [...] Read more.
The tumor microenvironment (TME) is pivotal in tumor growth and metastasis, aligning with the “Seed and Soil” theory. Within the TME, tumor-associated macrophages (TAMs) play a central role, profoundly influencing tumor progression. Strategies targeting TAMs have surfaced as potential therapeutic avenues, encompassing interventions to block TAM recruitment, eliminate TAMs, reprogram M2 TAMs, or bolster their phagocytic capabilities via specific pathways. Nanomaterials including inorganic materials, organic materials for small molecules and large molecules stand at the forefront, presenting significant opportunities for precise targeting and modulation of TAMs to enhance therapeutic efficacy in cancer treatment. This review provides an overview of the progress in designing nanoparticles for interacting with and influencing the TAMs as a significant strategy in cancer therapy. This comprehensive review presents the role of TAMs in the TME and various targeting strategies as a promising frontier in the ever-evolving field of cancer therapy. The current trends and challenges associated with TAM-based therapy in cancer are presented. Full article
(This article belongs to the Special Issue Functionalized Nanoparticles in Cancer Therapeutics, 2nd Edition)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop