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Pharmaceutics
Special Issues
Bioactive Polymers for Osteochondral Regeneration Applications
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Bioactive Polymers for Osteochondral Regeneration Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: closed (10 August 2023) | Viewed by 2373

Special Issue Editors

Dr. Xing Wang

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Guest Editor
State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry Chinese Academy of Sciences, No. 2 1st North Street Zhongguancun, Beijing 100190, China
Interests: hydrogel; stimuli-responsive polymers; bone regeneration, cartilage repair; hemostatic material; drug delivery; self-assembly
Special Issues, Collections and Topics in MDPI journals
Dr. Zibiao Li

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Guest Editor
Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Singapore
Interests: biomaterials; materials chemistry; design and synthesis of biodegradable polymer; polymeric self-assemblies; biomedical materials; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymers entail a wide-ranging clinical application and are of particular interest in healthcare. Recently, new methods to synthesize bioactive polymers and their potential to regenerate various tissues have gained popularity due to their low production costs and undemanding processing methods. Even with these splendid developments, there is a need for additional investigation to pursue advantageous bioactive polymer for medicine and dentistry-related clinical applications. Therefore, publishing developments related to these bioactive polymers would be advantageous for researchers, academicians and physicians.

Dr. Xing Wang
Dr. Zibiao Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthetic and natural biopolymers
  • hyderogell
  • bioactive materials
  • tissue engineering
  • regenerative medicine
  • scaffolds for bone and cartilage tissue regeneration
  • cellular and tissue-based products
  • drug delivery
  • biofunctionalization

Published Papers (2 papers)

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Research

12 pages, 3687 KiB  
Article
Flexible Fabrication and Hybridization of Bioactive Hydrogels with Robust Osteogenic Potency
by Liang Zhu, Qian Hou, Meijun Yan, Wentao Gao, Guoke Tang and Zhiqing Liu
Pharmaceutics 2023, 15(10), 2384; https://doi.org/10.3390/pharmaceutics15102384 - 26 Sep 2023
Cited by 1 | Viewed by 843
Abstract
Osteogenic scaffolds reproducing the natural bone composition, structures, and properties have represented the possible frontier of artificially orthopedic implants with the great potential to revolutionize surgical strategies against the bone-related diseases. However, it is difficult to achieve an all-in-one formula with the simultaneous [...] Read more.
Osteogenic scaffolds reproducing the natural bone composition, structures, and properties have represented the possible frontier of artificially orthopedic implants with the great potential to revolutionize surgical strategies against the bone-related diseases. However, it is difficult to achieve an all-in-one formula with the simultaneous requirement of favorable biocompatibility, flexible adhesion, high mechanical strength, and osteogenic effects. Here in this work, an osteogenic hydrogel scaffold fabricated by inorganic-in-organic integration between amine-modified bioactive glass (ABG) nanoparticles and poly(ethylene glycol) succinimidyl glutarate-polyethyleneimine (TSG-PEI) network was introduced as an all-in-one tool to flexibly adhere onto the defective tissue and subsequently accelerate the bone formation. Since the N-hydroxysuccinimide (NHS)-ester of tetra-PEG-SG polymer could quickly react with the NH2-abundant polyethyleneimine (PEI) polymer and ABG moieties, the TSG-PEI@ABG hydrogel was rapidly formed with tailorable structures and properties. Relying on the dense integration between the TSG-PEI network and ABG moieties on a nano-scale level, this hydrogel expressed powerful adhesion to tissue as well as durable stability for the engineered scaffolds. Therefore, its self-endowed biocompatibility, high adhesive strength, compressive modulus, and osteogenic potency enabled the prominent capacities on modulation of bone marrow mesenchymal stem cell (BMSCs) proliferation and differentiation, which may propose a potential strategy on the simultaneous scaffold fixation and bone regeneration promotion for the tissue engineering fields. Full article
(This article belongs to the Special Issue Bioactive Polymers for Osteochondral Regeneration Applications)
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13 pages, 3939 KiB  
Article
Fabrication of Injectable Kartogenin-Conjugated Composite Hydrogel with a Sustained Drug Release for Cartilage Repair
by Chao Li, Yubo Liu, Tujun Weng, Muyuan Yang, Xing Wang and Wei Chai
Pharmaceutics 2023, 15(7), 1949; https://doi.org/10.3390/pharmaceutics15071949 - 14 Jul 2023
Cited by 4 | Viewed by 1253
Abstract
Cartilage tissue engineering has attracted great attention in defect repair and regeneration. The utilization of bioactive scaffolds to effectively regulate the phenotype and proliferation of chondrocytes has become an elemental means for cartilage tissue regeneration. On account of the simultaneous requirement of mechanical [...] Read more.
Cartilage tissue engineering has attracted great attention in defect repair and regeneration. The utilization of bioactive scaffolds to effectively regulate the phenotype and proliferation of chondrocytes has become an elemental means for cartilage tissue regeneration. On account of the simultaneous requirement of mechanical and biological performances for tissue-engineered scaffolds, in this work we prepared a naturally derived hydrogel composed of a bioactive kartogenin (KGN)-linked chitosan (CS-KGN) and an aldehyde-modified oxidized alginate (OSA) via the highly efficient Schiff base reaction and multifarious physical interactions in mild conditions. On the basis of the rigid backbones and excellent biocompatibility of these two natural polysaccharides, the composite hydrogel demonstrated favorable morphology, easy injectability, good mechanical strength and tissue adhesiveness, low swelling ratio, long-term sustainable KGN release, and facilitated bone marrow mesenchymal stem cell activity, which could simultaneously provide the mechanical and biological supports to promote chondrogenic differentiation and repair the articular cartilage defects. Therefore, we believe this work can offer a designable consideration and potential alternative candidate for cartilage and other soft tissue implants. Full article
(This article belongs to the Special Issue Bioactive Polymers for Osteochondral Regeneration Applications)
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