Cyclodextrin-Based Drug Delivery Systems
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 406
Special Issue Editor
Special Issue Information
Dear Colleagues,
The efficacy of small-molecule active pharmaceutical ingredients (API) is often plagued by insolubility and a poor tissue distribution when administered in free form. Cyclodextrins are torus-shaped cyclic oligoamyloses composed of D-glucose units that are joined by α-1,4-glycosidic linkages. They are extensively employed as supramolecular hosts for drug solubilization owing to their well-defined hydrophobic interior cavity and their hydrophilic exterior, which imparts substantial aqueous solubility. Moreover, the primary and secondary hydroxyl groups of the cyclodextrin molecule provide a synthetic handle for a range of modifications and derivatizations. To this end, modified architectures spanning single-unit modification (i.e., randomly methylated (RAME-β-CD), sulpho-butyl ether (Captisol)) to higher-order architectures (cyclodextrin oligomers, nanosponges (NS)) have been employed in the literature for drug solubilization, as well as their sustained release and enhanced bioavailability.
This Special Issue serves to highlight and capture contemporary advances in cyclodextrins and cylodextrin-based chemical moieties in the context of their pharmaceutical benefits, such as drug solubilization, nanoparticle formulations, sustained release and the improved pharmacokinetics of small-molecule APIs. We welcome the submission of articles addressing all aspects of cyclodextrin-based drug formulations, highlighting the unique advantages of these molecules across the pharmaceutical landscape.
Dr. Sauradip Chaudhuri
Guest Editor
Manuscript Submission Information
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Keywords
- cyclodextrins
- sustained drug release
- modified cyclodextrins
- drug solubilization
- hydrophobicity
- bioavailability
- cyclodextrin polymers
