Special Issue "Strategies for Enhancing the Bioavailability of Poorly Soluble Drugs, 2nd Edition"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: closed (20 September 2023) | Viewed by 644

Special Issue Editor

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN 47906, USA
Interests: solubility; solubilization; amorphous; cocrystals; extrusion; polymers; excipients; films
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Special Issue Information

Dear Colleagues,

Bioavailability is crucial for the successful development of pharmaceutical products, be it a novel drug or a new formulation of an existing drug. The interplay between drug solubility/solubilization and bioavailability is particularly interesting and relevant from both scientific and commercial standpoints, respectively. Bioavailability is the result of interweaving underlying physical and physiological phenomena. Accordingly, progress toward enhancing the bioavailability of poorly soluble drugs entails a multi-disciplinary approach, involving, among other things, physical characterization of solids, solution chemistry, pharmaceutical excipients, pharmaceutical processing, drug transporters and absorption enhancers. With the advent of patient-centric formulations, it is more important than ever to gather published sources detailing the latest advances toward a fundamental understanding of the bioavailability–solubility relationship from the various perspectives of sub-disciplines involved in this important pharmaceutical subject. This Special Issue of Pharmaceutics is brought to you with that aim.

Dr. Rodolfo Pinal
Guest Editor

Manuscript Submission Information

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Keywords

  • absorption enhancers
  • additive manufacturing
  • amorphous
  • co-crystals
  • co-processed excipients
  • extrusion
  • lipid formulations
  • lipid nanoparticles
  • pharmaceutical material science
  • particle engineering
  • patient-centric
  • polymers
  • polymorphs
  • self-emulsifying delivery systems
  • solid dispersions
  • solubility
  • solubilization
  • spray-drying
  • supersaturation
  • transporters

Published Papers (1 paper)

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Research

Article
Tunable Drug Release Rate Using Modular Oral Dosage Forms
Pharmaceutics 2023, 15(7), 1905; https://doi.org/10.3390/pharmaceutics15071905 - 08 Jul 2023
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Abstract
Oral dosage forms with adjustable drug release profiles were prepared using progesterone (PGR) as a poorly-soluble model drug. The dosage forms were made as stack assemblies of functional modules. The modules were made as PGR-carrying HPMC films cut into wafer-like circular pieces. Two [...] Read more.
Oral dosage forms with adjustable drug release profiles were prepared using progesterone (PGR) as a poorly-soluble model drug. The dosage forms were made as stack assemblies of functional modules. The modules were made as PGR-carrying HPMC films cut into wafer-like circular pieces. Two types of modules were used in the study; one exhibited comparatively fast drug release and the other slow release. The fast vs. slow release of each type of film utilized resulted from the grade of HPMC used in each case. Drug loading in the assembly was controlled through the total number of modules. By adjusting the proportions of the two types of modules, it is possible to fine-tune the drug release rate of the multi-layer assemblies to a wide range of profiles, bracketed between a high and low end, corresponding to the inherently fastest or slowest release obtainable with the specific materials and procedures employed. This procedure is suitable for adjusting the spring-and-parachute parameters for enhancing/optimizing the bioavailability of poorly-soluble drugs, and for developing patient-centric formulations. Full article
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