Dose Optimization of Traditional and New Drug Formulations in Veterinary and Human Medicine

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 752

Special Issue Editors


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Guest Editor
Faculty of Veterinary Medicine, Trakia University, 6015 Stara Zagora, Bulgaria
Interests: veterinary pharmacology; ABC transporter proteins; pharmacokinetics; pharmacokinetic-pharmacodynamic modelling
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Guest Editor
Faculty of Medicine, Trakia University, 6000 Stara Zagora, Bulgaria
Interests: pharmacology; pharmacokinetics; pharmacovigilance; dietary supplements

Special Issue Information

Dear Colleagues,

We are pleased to invite you to share your knowledge and experience by publishing within the Special Issue focused on dose optimization strategies for old and new drug formulations in veterinary and human medicine.

The aim of this Special Issue is to reveal the power of advanced models such as pharmacokinetic-pharmacodynamic models, physiologically based pharmacokinetic and pharmacodynamics models, the population pharmacokinetic approach and all other methods that can contribute to dose optimization in a diverse population and that can improve the use of available old and new drug formulations in clinical settings or in veterinary practice with farm and companion animals.

Original research articles and reviews are welcome. Research areas may include (but are not limited to) the following crucial issues for the successful therapy of animals and humans: pharmacokinetic and pharmacodynamics studies which suggest optimization of the dosing regimens of new and older drug molecules; drug–dietary (food) supplements interactions; drug–drug interactions and drug–feed additives interactions are also of great interest if adjustment of the dosing regimen is required. New drug formulations with improved pharmacokinetic and pharmacodynamics profiles are of interest.

We look forward to receiving your contributions with the hope of shedding more light on the contemporary options for the optimization of drug administration of available old and new pharmaceutical formulations.

Prof. Dr. Aneliya Milanova
Dr. Zhivka Tsokeva
Guest Editors

Manuscript Submission Information

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Keywords

  • dose optimization
  • pharmacokinetics
  • pharmacodynamics
  • drug–drug interactions
  • drug–feed/feed additives interactions
  • drug/dietary supplement interactions

Published Papers (1 paper)

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Research

13 pages, 1331 KiB  
Article
Pharmaceutical Compounding in Veterinary Medicine: Suspension of Itraconazole
by Gema J. Cabañero-Resta, Bárbara Sánchez-Dengra, Alejandro Ruiz-Picazo, Marival Bermejo, Virginia Merino, Isabel Gonzalez-Alvarez and Marta Gonzalez-Alvarez
Pharmaceutics 2024, 16(5), 576; https://doi.org/10.3390/pharmaceutics16050576 - 24 Apr 2024
Abstract
Itraconazole is a drug used in veterinary medicine for the treatment of different varieties of dermatophytosis at doses between 3–5 mg/kg/day in cats. Nevertheless, in Spain, it is only available in the market as a 52 mL suspension at 10 mg/mL. The lack [...] Read more.
Itraconazole is a drug used in veterinary medicine for the treatment of different varieties of dermatophytosis at doses between 3–5 mg/kg/day in cats. Nevertheless, in Spain, it is only available in the market as a 52 mL suspension at 10 mg/mL. The lack of alternative formulations, which provide sufficient formulation to cover the treatment of large animals or allow the treatment of a group of them, can be overcome with compounding. For this purpose, it has to be considered that itraconazole is a weak base, class II compound, according to the Biopharmaceutics Classification System, that can precipitate when reaching the duodenum. The aim of this work is to develop alternative oral formulations of itraconazole for the treatment of dermatophytosis. Several oral compounds of itraconazole were prepared and compared, in terms of dissolution rate, permeability, and stability, in order to provide alternatives to the medicine commercialized. The most promising formulation contained hydroxypropyl methylcellulose and β-cyclodextrin. This combination of excipients was capable of dissolving the same concentration as the reference product and delaying the precipitation of itraconazole upon leaving the stomach. Moreover, the intestinal permeability of itraconazole was increased more than two-fold. Full article
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