Special Issue "20th Anniversary of Pharmaceuticals—Green Techniques for Organic and Organometallic/Coordination Synthesis and Medicinal Chemistry"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 November 2023 | Viewed by 995

Special Issue Editors

LAQV-REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
Interests: mechanochemistry; deep eutectic solvents; green chemistry; pharmaceutical formulations; crystal engineering; multivariate data analysis
Special Issues, Collections and Topics in MDPI journals
LAQV-REQUIMTE, Departamento de Química, Faculdade Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal
Interests: mechanochemistry; coordination/organometallic chemistry; crystallography; supramolecular chemistry; homogeneous catalysis; green chemistry; crystal engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Throughout the years, creating a safer, greener world has been a challenge. The constant global increasing population and necessities, production requirements, and consumption per capita, are all impacting the way we produce, create, and evolve. The pharmaceutical and chemical industries represent a big part of our evolution, creating new ways to make humanity prosper by improving health; however, the mandatory world necessities are making these sectors unable to meet greener and ecologically safer solutions. Green Chemistry (GC) represents a new method aimed at making chemistry environmentally friendly and advantageous for the evolution of the pharmaceutical and chemistry industry.

The main aim of this Special Issue "Green Techniques for Organic and Organometallic/Coordination Synthesis and Medicinal Chemistry." is to create an open forum where scientists can share their research and discoveries in this promising field and increase their visibility as well as create opportunities for interaction with industries and production systems. The contributions to this Special Issue, in the form of original research or review articles, may cover all aspects of the synthesis of organic and coordination compounds as well as medicinal chemistry using green chemistry approaches.

Dr. Mafalda Cruz Sarraguca
Dr. Clara Gomes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green chemistry
  • medicinal chemistry
  • organometallic synthesis
  • coordination synthesis
  • organic synthesis

Published Papers (1 paper)

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Research

15 pages, 4531 KiB  
Article
Pyrrole-Doped Polydopamine-Pyrrole (PDA-nPY) Nanoparticles with Tunable Size and Improved NIR Absorption for Photothermal Therapy
Pharmaceuticals 2023, 16(12), 1642; https://doi.org/10.3390/ph16121642 - 23 Nov 2023
Viewed by 314
Abstract
Polydopamine (PDA) as a melanin-like biomimetic material with excellent biocompatibility, full spectrum light absorption capacity and antioxidation property has been extensively applied in the biomedical field. Based on the high reactivity of dopamine (DA), exploiting new strategies to fabricate novel PDA-based nano-biomaterials with [...] Read more.
Polydopamine (PDA) as a melanin-like biomimetic material with excellent biocompatibility, full spectrum light absorption capacity and antioxidation property has been extensively applied in the biomedical field. Based on the high reactivity of dopamine (DA), exploiting new strategies to fabricate novel PDA-based nano-biomaterials with controllable size and improved performance is valuable and desirable. Herein, we reported a facile way to synthesize pyrrole-doped polydopamine-pyrrole nanoparticles (PDA-nPY NPs) with tunable size and enhanced near-infrared (NIR) absorption capacity through self-oxidative polymerization of DA with PY in an alkaline ethanol/H2O/NH4OH solution. The PDA-nPY NPs maintain excellent biocompatibility and surface reactivity as PDA. By regulating the volume of added PY, PDA-150PY NPs with a smaller size (<100 nm) and four-fold higher absorption intensity at 808 nm than that of PDA can be successfully fabricated. In vitro and in vivo experiments effectively further demonstrate that PDA-150PY NPs can effectively inhibit tumor growth and completely thermally ablate a tumor. It is believed that these PY doped PDA-nPY NPs can be a potential photothermal (PT) agent in biomedical application. Full article
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