Polyphenols in the Treatment for Neuroinflammation-Induced Neurodegenerative Disease
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".
Deadline for manuscript submissions: 25 June 2024 | Viewed by 5694
Special Issue Editors
Interests: amyloid aggregation; autophagy; natural polyphenols; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Interests: bioactive natural products; inflammation; oxidative stress; polyphenols; cell migration; autophagy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroinflammation is defined as an inflammatory response within the brain or spinal cord. This inflammation is mediated by the production of cytokines, chemokines, reactive oxygen species, and secondary messengers. These mediators are produced by resident CNS glia (microglia and astrocytes), endothelial cells, and peripherally derived immune cells. There are immune, physiological, biochemical, and psychological consequences of these neuroinflammatory responses. Moreover, the degree of neuroinflammation depends on the context, duration, and course of the primary stimulus or insult. In recent years, neuroinflammation has attracted particular interest, and genetic variants of molecules associated with ‘‘microgliopathies’’ result in increased risk of developing neurodegenerative disorders and cognitive decline. Current therapies for neurodegenerative disorders treat symptoms and final manifestations, including aggregate build-up, memory loss, behavioral changes, and sleep deficits; however, this strategy is not a sustainable approach to appropriate management of disease onset or progression. One of the more promising approaches considers the inhibition of amyloid formation by small-molecule inhibitors; however, multiple failures of clinical therapeutic approaches indicate that the current strategies must be modulated and emphasize the importance of targeting pre-symptomatic signs as oxidative stress and inflammation. Both oxidative stress and neuroinflammation preside over the symptomology of neurodegenerative disorders, and each promotes neurotoxic environments associated with neurodegeneration.
In this scenario, polyphenols represent a promising starting point for new preventive and therapeutic approaches, since they target effectively and simultaneously inflammatory and oxidative pathways, and amyloid aggregation. These molecules have worldwide availability, low cost, and low toxicity. Improved knowledge of these topics is mandatory to promote the use of natural polyphenols well beyond their known antioxidant, antidiabetic, and antilipidemic effects. Increased information in this sense could be exploited to enrich, from a commercial and nutraceutical point of view, the alimentary and healthy value of natural compounds.
Dr. Manuela Leri
Dr. Marzia Vasarri
Guest Editors
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