The Pharmacological Management of Bone and Muscle Disorders
Deadline for manuscript submissions: 15 March 2024 | Viewed by 1724
Interests: muscle; bone; osteosarcopenia; nutraceuticals; skeletal muscle metabolism; muscle atrophy treatment; osteoporosis treatment
Special Issues, Collections and Topics in MDPI journals
Skeletal muscles are dynamic tissues capable of adapting in response to a variety of signals. Skeletal muscles experience mass changes as a result of physical activity, metabolism, and hormones. Atrophy is defined as a decrease in the size of a tissue or organ due to a decrease in cell size caused by the loss of organelles, cytoplasm, and proteins. This complex process occurs in skeletal muscle as a consequence of a variety of stressors, including neural inactivity, mechanical unloading, inflammation, metabolic stress, and elevated glucocorticoid levels. Muscle mass, in turn, depends on protein turnover. Muscle atrophy occurs when the rate of protein degradation exceeds that of protein synthesis.
The integrity of bone tissue is also maintained by a delicate balance between bone resorption (by osteoclasts) and bone formation (by osteoblasts). During physiological aging or pathology, this balance is altered, and pharmacological treatment must be carried out in an attempt to restore the balance. Drugs capable of restoring this balance are valuable for the treatment of pathologies such as osteoporosis, Paget's disease, rheumatoid arthritis, or periodontal disease.
Much less attention has been paid to promoting bone formation with, for example, growth factors or hormones, an approach that would represent a valuable adjunctive therapy for patients receiving bone resorption inhibitors.
This Special Issue of Pharmaceuticals, entitled “The Pharmacological Management of Bone and Muscle Disorders”, focuses on the pharmacological treatment of bone and muscle diseases and will therefore cover recent advances in the treatment of such diseases, including muscle atrophy, osteoporosis, and osteosarcopenia.
This Special Issue aims to collect articles that will further our understanding of the molecular mechanisms involved in bone and muscle disorders and the potential of their associated drugs, natural products, growth factors, and hormones. Topics of interest include the development and characterization of novel pharmaceutical approaches. Experimental papers and review articles are both welcome.
Dr. Francesca Bosco
Manuscript Submission Information
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- skeletal muscle metabolism
- pharmacological management