Special Issue "Natural Products for Potential Use of Neuroprotective and Neurorestorative Effects"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 25 February 2024 | Viewed by 656

Special Issue Editors

Dr. Lorenza Guarnieri
E-Mail Website
Guest Editor
Section of Pharmacology, Science of Health Department, School of Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
Interests: neurodegenerative disease; natural compounds; nutraceuticals; nutritional interventions; cognitive impairment
Department of Health Sciences, Institute of Research for Food Safety and Health (IRC-FSH), University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
Interests: neuroinflammation; neurodegeneration; nutraceuticals; cognitive impairment; natural compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neurodegenerative diseases result from a variety of pathological conditions characterized by significant cellular damage, abnormal protein presence and altered connections of the nervous system that can impair the patient's life quality. It is estimated that neurodegenerative diseases affect millions of individuals worldwide and the likelihood of developing neurodegenerative disease increases dramatically with age. The presence of abnormal proteins and increased oxidative stress contribute to accelerating neuroinflammatory and neurodegenerative processes. To date, considerable progress has been made in identifying the molecular mechanisms and pathways underlying neurodegenerative diseases; however, identifying safe and effective drug therapies for treating these disorders is very arduous. Pharmacological therapies in use for the treatment of neurodegenerative disease are still ineffective in modifying pathological changes and neurological disorders, and they provide only symptomatic relief; therefore, it is essential to seek new therapeutic strategies to treat these diseases. Natural compounds have aroused considerable interest in this field, also proving to be a possible alternative to the synthetic drugs used. Natural compounds may exert positive effects on aging-related changes in the brain and are capable of modulating neurological processes, given their ability to interact with neuronal–glial signaling pathways that are implicated in neuronal survival and function. In this Special Issue, we aim to bring together research from experts in the field highlighting the neuroprotective capabilities of natural compounds to identify future directions that will lead to discoveries and alternative therapies for neurological disorders.

Dr. Lorenza Guarnieri
Dr. Francesca Bosco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neurodegenerative disease
  • neurodegeneration
  • neuroinflammation
  • nutritional interventions
  • brain damage
  • neurological diseases
  • natural compounds

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


18 pages, 9544 KiB  
Rubia cordifolia L. Attenuates Diabetic Neuropathy by Inhibiting Apoptosis and Oxidative Stress in Rats
Pharmaceuticals 2023, 16(11), 1586; https://doi.org/10.3390/ph16111586 - 09 Nov 2023
Viewed by 445
Background: Diabetic neuropathy is a debilitating manifestation of long-term diabetes mellitus. The present study explored the effects of the roots of Rubia cordifolia L. (R. cordifolia L.) in the Wistar rat model for diabetic neuropathy and possible neuroprotective, antidiabetic, and analgesic mechanisms [...] Read more.
Background: Diabetic neuropathy is a debilitating manifestation of long-term diabetes mellitus. The present study explored the effects of the roots of Rubia cordifolia L. (R. cordifolia L.) in the Wistar rat model for diabetic neuropathy and possible neuroprotective, antidiabetic, and analgesic mechanisms underlying this effect. Materials and Methods: Rats were divided into five experimental groups. An amount of 0.25% carboxy methyl cellulose (CMC) in saline and streptozotocin (STZ) (60 mg/kg) was given to group 1 and group 2, respectively. Group 3 was treated with STZ and glibenclamide simultaneously while groups 4 and 5 were simultaneously treated with STZ and hydroalcoholic extract of the root of R. cordifolia, respectively. Hot plate and cold allodynias were used to evaluate the pain threshold. The antioxidant effects of R. cordifolia were assessed by measuring Thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD). At the end of the study, sciatic nerve and brain tissues were collected for histopathological study. Bcl-2 proteins, cleaved caspase-3, and Bax were assessed through the Western blot method. Results: R. cordifolia significantly attenuated paw withdrawal and tail flick latency in diabetic neuropathic rats. R. cordifolia significantly (p < 0.01) improved the levels of oxidative stress. It was found to decrease blood glucose levels and to increase animal weight in R. cordifolia-treated groups. Treatment with R. cordifolia suppressed the cleaved caspase-3 and reduced the Bax:Bcl2 ratio in sciatic nerve and brain tissue compared to the diabetic group. Histopathological analysis also revealed a marked improvement in architecture and loss of axons in brain and sciatic nerve tissues at a higher dose of R. cordifolia (400 mg/kg). Conclusion: R. cordifolia attenuated diabetic neuropathy through its antidiabetic and analgesic properties by ameliorating apoptosis and oxidative stress. Full article
Show Figures

Figure 1

Back to TopTop