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Pharmaceuticals
Special Issues
Affecting Monoaminergic Transmission as the Method to Treat the Cognitive...
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Affecting Monoaminergic Transmission as the Method to Treat the Cognitive Impairments of Different Origins

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: closed (25 January 2024) | Viewed by 1777

Special Issue Editor

Dr. Szczepan Mogilski

E-Mail Website
Guest Editor
Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, PL 30-688 Krakow, Poland
Interests: research into pharmacological mechanisms of analgesia and antipruritic activity; basic and preclinical studies into memory-enhancing molecules; drug design and development in analgesia and cognition; searching for new mechanisms of action of small molecules impacting endothelial dysfunction, atherogenesis, platelet aggregation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Monoaminergic transmission (including dopamine, serotonin, norepinephrine and histamine) plays a pivotal role in CNS, regulating many functions. There are many possible pharmacological mechanisms influencing that transmission.

This Special Issue aims to collect reviews and articles revealing how those different mechanisms may ameliorate cognitive dysfunctions associated with various conditions, such as neurodegenerative disorders, schizophrenia, depression or stroke.

Dr. Szczepan Mogilski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • monoaminergic transmission
  • learning
  • memory
  • cognition
  • neurodegenerative disorders
  • schizophrenia
  • depression
  • stroke

Published Papers (1 paper)

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Review

23 pages, 1967 KiB  
Review
Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor–Receptor Interactions
by Diego Guidolin, Cinzia Tortorella, Manuela Marcoli, Chiara Cervetto, Raffaele De Caro, Guido Maura and Luigi F. Agnati
Pharmaceuticals 2023, 16(10), 1427; https://doi.org/10.3390/ph16101427 - 08 Oct 2023
Viewed by 1574
Abstract
Dopamine neurotransmission plays critical roles in regulating complex cognitive and behavioral processes including reward, motivation, reinforcement learning, and movement. Dopamine receptors are classified into five subtypes, widely distributed across the brain, including regions responsible for motor functions and specific areas related to cognitive [...] Read more.
Dopamine neurotransmission plays critical roles in regulating complex cognitive and behavioral processes including reward, motivation, reinforcement learning, and movement. Dopamine receptors are classified into five subtypes, widely distributed across the brain, including regions responsible for motor functions and specific areas related to cognitive and emotional functions. Dopamine also acts on astrocytes, which express dopamine receptors as well. The discovery of direct receptor–receptor interactions, leading to the formation of multimeric receptor complexes at the cell membrane and providing the cell decoding apparatus with flexible dynamics in terms of recognition and signal transduction, has expanded the knowledge of the G-protein-coupled receptor-mediated signaling processes. The purpose of this review article is to provide an overview of currently identified receptor complexes containing dopamine receptors and of their modulatory action on dopamine-mediated signaling between neurons and between neurons and astrocytes. Pharmacological possibilities offered by targeting receptor complexes in terms of addressing neuropsychiatric disorders associated with altered dopamine signaling will also be briefly discussed. Full article
(This article belongs to the Special Issue Affecting Monoaminergic Transmission as the Method to Treat the Cognitive Impairments of Different Origins)
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