Special Issue "Antioxidants in the Processes of Retarding Ageing"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 10 February 2024 | Viewed by 1469

Special Issue Editors

Department of Biochemistry and Cell Biology, Institute of Biology and Biotechnology, University of Rzeszów, Zelwerowicza 4 Street, 35-601 Rzeszów, Poland
Interests: aging; antioxidants; cell cycle regulation; cell death; longevity; yeast biology
Special Issues, Collections and Topics in MDPI journals
Department of Biochemistry and General Chemistry, Institute of Medical Sciences, Medical College of Rzeszow University, Warzywna 1a, 35-310 Rzeszów, Poland
Interests: glycation; glycoxidative and oxidative damage; nitric oxide; oxidative stress; reactive oxygen species
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Aging is defined as progressive physiological changes in an organism that lead to senescence, or a decline in biological functions and in the organism’s ability to adapt to metabolic stress. Numerous hypotheses exist to explain the organismal, cellular, and molecular mechanisms that underlie aging. A recent study indicates that aging is caused by an accumulation of molecular damage, e.g., from reactive oxygen species. Thus, it becomes increasingly important to find compounds that have antioxidant properties to slow down the aging process. In this issue, we invite manuscripts examining the biochemical and molecular mechanisms of action of antioxidants on aging based on model organisms and human cell lines as a crucial biological resource. Studies based on yeast, fruit flies, worms, mice, and rats are welcome. Focused original research articles and review paper are both welcome.

Dr. Mateusz Mołoń
Dr. Sabina Galiniak
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • anti-aging medicine
  • antioxidant
  • model organisms
  • oxidative stress markers
  • reactive oxygen species

Published Papers (1 paper)

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Research

12 pages, 2413 KiB  
Article
SIRT1 Signaling Is Involved in the Vascular Improvement Induced by Moringa Oleifera Seeds during Aging
Pharmaceuticals 2023, 16(5), 761; https://doi.org/10.3390/ph16050761 - 18 May 2023
Cited by 1 | Viewed by 1156
Abstract
Vascular aging is linked to reduce NO bioavailability, endothelial dysfunction, oxidative stress, and inflammation. We previously showed that a 4-week treatment of middle-aged Wistar rats (MAWRs, 46 weeks old) with Moringa oleifera seed powder (MOI, 750 mg/kg/day) improved vascular function. Here, we investigated [...] Read more.
Vascular aging is linked to reduce NO bioavailability, endothelial dysfunction, oxidative stress, and inflammation. We previously showed that a 4-week treatment of middle-aged Wistar rats (MAWRs, 46 weeks old) with Moringa oleifera seed powder (MOI, 750 mg/kg/day) improved vascular function. Here, we investigated the involvement of SIRT1 in MOI-induced vascular improvement. MAWRs were treated with a standard or MOI-containing diet. Young rats (YWR, 16 weeks old) were the controls and received a standard diet. The hearts and aortas were harvested to evaluate SIRT1 and FOXO1 expression via Western blot and/or immunostaining, SIRT1 activity via a fluorometric assay, and oxidative stress using the DHE fluorescent probe. In the hearts and aortas, SIRT1 expression, reduced in MAWRs compared to YWRs, was enhanced in MOI MAWRs. In the hearts, SIRT1 activity did not differ between YWRs and MAWRs, whereas it was increased in MOI MAWRs compared with them. In the aortas, SIRT1 activity decreased in MAWRs, and it was similar in the MOI MAWRs and YWRs. FOXO1 expression increased in the nuclei of MAWR aortas compared to YWR and was reversed in MOI MAWRs. Interestingly, MOI treatment normalized oxidative stress enhanced in MAWRs, in both the heart and aorta. These results demonstrate the protective role of MOI against cardiovascular dysfunction due to aging via enhanced SIRT1 function and subsequently reduced oxidative stress. Full article
(This article belongs to the Special Issue Antioxidants in the Processes of Retarding Ageing)
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