Special Issue "Phytochemicals and Analogues as Sources of Bioactive Substances of Pharmacological and Industrial Interest"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 31 March 2024 | Viewed by 1858

Special Issue Editors

1. Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), CESPU, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal
2. LAQV-REQUIMTE, Department of Chemistry Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
Interests: organic chemistry; analytical chemistry; mass spectrometry; heterocyclic compounds
Special Issues, Collections and Topics in MDPI journals
TOXRUN–Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, Portugal
Interests: chromatography; chiral drugs; pharmaceuticals; environmental contaminants
Special Issues, Collections and Topics in MDPI journals
1. Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
2. CIIMAR–Interdisciplinary Centre of Marine and Environmental Research, Edifício do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal
3. TOXRUN–Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, Portugal
Interests: organic and pharmaceutical chemistry; chromatography; chirality; organic environmental pollutants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Phytochemicals as bioactive compounds are of great value as they have important applications in various fields. Indeed, the so called "secondary metabolites” or “plant-based chemicals” are the subject of continuous research for the development and design of new drugs, cosmetics, food additives or preservatives, pesticides, and other products.

Many phytochemicals have recognized pharmacological properties, including antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. The classical example is the compound artemisinin, found in the plant Artemisia annua, used as an antimalarial drug. Flavonoids, common in many fruits and vegetables, have been shown to have antioxidant, anti-inflammatory and anticancer properties. Another example is the use of certain plant extracts in skin care products for their anti-aging or anti-inflammatory properties.

Overall, the pharmacological interest of phytochemicals lies in their potential to provide a direct benefit for society by providing new and innovative products in industries related with the sustainable development of drugs, pesticides (food and agriculture), cosmetics and personal cares products, etc.

This Special Issue, “Phytochemicals and Analogues as Sources of Bioactive Substances of pharmacological and Industrial Interest”, invites authors to contribute review or original research articles dedicated to the most recent advances in the discovery of plant-based phytochemicals. Contributions may include the discovery of new compounds and their structural elucidation or synthetic analogues as well as the assessment of the pharmacological properties. Structure–activity studies directing toward eco-friendly methodologies for the synthesis of more bioactive derivatives are also welcomed.

Prof. Dr. Eduarda M. P. Silva
Dr. Cláudia Maria Rosa Ribeiro
Dr. Maria Elizabeth Tiritan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Natural products
  • Phytochemical
  • Biologically active
  • Secondary metabolites

Published Papers (1 paper)

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Research

14 pages, 9800 KiB  
Article
Phytochemical Investigation of Equisetum arvense and Evaluation of Their Anti-Inflammatory Potential in TNFα/INFγ-Stimulated Keratinocytes
Pharmaceuticals 2023, 16(10), 1478; https://doi.org/10.3390/ph16101478 - 16 Oct 2023
Viewed by 1260
Abstract
Equisetum arvense L. (Equisetaceae), widely known as ‘horsetail’, is a perennial plant found extensively across Asia. Extracts of E. arvense have been used in traditional medicine, particularly for the treatment of inflammatory disorders. This study aimed to determine the phytochemical compounds in E. [...] Read more.
Equisetum arvense L. (Equisetaceae), widely known as ‘horsetail’, is a perennial plant found extensively across Asia. Extracts of E. arvense have been used in traditional medicine, particularly for the treatment of inflammatory disorders. This study aimed to determine the phytochemical compounds in E. arvense ethanolic extract and their anti-inflammatory properties. Subsequently, we isolated and identified nine secondary metabolites, including kaempferol 3,7-di-O-β-D-glucopyranoside (1), icariside B2 (2), (Z)-3-hexenyl β-D-glucopyranoside (3), luteolin 5-O-β-D-glucopyranoside (4), 4-O-β-D-glucopyranosyl caffeic acid (5), clemastanin B (6), 4-O-caffeoylshikimic acid (7), (7S,8S)-threo-7,9,9′-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-4-O-β-D-glucopyranoside (8), and 3-O-caffeoylshikimic acid (9). The chemical structures of the isolated compounds (1–9) were elucidated using HR-ESI-MS data, NMR spectra, and ECD data. Next, the anti-inflammatory effects of the isolates were evaluated in tumor necrosis factor (TNF)α/interferon (IFN)γ-induced HaCaT, a human keratinocyte cell line. Among the isolates, compound 3 showed the highest inhibitory effect on the expression of pro-inflammatory chemokines, followed by compounds 6 and 8. Correspondingly, the preceding isolates inhibited TNFα/IFNγ-induced activation of pro-inflammatory transcription factors, signal transducer and activator of transcription 1, and nuclear factor-κB. Collectively, E. arvense could be employed for the development of prophylactic or therapeutic agents for improving dermatitis. Full article
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