A special issue of Symmetry (ISSN 2073-8994).
Deadline for manuscript submissions: closed (30 June 2017) | Viewed by 33545
2. TOXRUN–Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, Portugal
Interests: organic and pharmaceutical chemistry; chromatography; chirality; organic environmental pollutants
Special Issues, Collections and Topics in MDPI journals
The importance of chiral separation has been known since Louis Pasteur verified that (-)-tartaric acid was not being metabolized, or was being metabolized much slower than (+)-tartaric acid by Penicillium glaucum in the wine-fermentation process. A few years later, Emile Fischer observed the consequence of the enzymes in selective metabolism by microorganisms, after analyzing the crude extracts of yeast and a preparation obtained from almonds, he found out that only one of the isomers of the monosaccharide methylglucoside was present in each solution. By the same time, in 1886, the Italian chemist Arnaldo Piutti found that D-asparagine was responsible for the sweet taste while L-asparagine was tasteless. Nowadays, the influence of chirality in biological systems is an established fact that should always be kept in mind in the design of new drugs, pesticides, food additives and even fragrances. The biological response of each enantiomer must always be evaluated before its commercialization. Given the verified importance of chirality in the biological systems, the separation of enantiomers is of crucial importance in analytical (quality control) and in the preparative methods to obtain pure enantiomers. Accordingly, the aim of this Special Issue, “Chiral Separations”, is to reunite the different tools regarding separation of enantiomers in preparative and analytical mode. It is important to present not only the results from well establish methodologies such as chiral chromatography but to highlight innovations within chiral separations. Contributions which address innovations in selective liquid–liquid extraction, membrane separation, crystallization, kinetic or dynamic kinetic resolution, chromatography, and capillary electrophoresis are cordially invited.
Prof. Dr. Maria Elizabeth Tiritan
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- Chiral chromatography
- Enantioselective liquid–liquid extraction
- Chiral Capillary Electrophoresis
- Kinetic resolution
- Enantiomeric purity