Special Issue "Immunopathogenesis of Tuberculosis: Potential Implications for Clinical Management"

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Immunological Responses and Immune Defense Mechanisms".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 152

Special Issue Editor

Department of Infectious Diseases, Bellvitge University Hospital-Bellvitge Institute for Biomedical Research (IDIBELL), University of Barcelona, Barcelona, Spain
Interests: Mycobacteria; tuberculosis; central nervous tuberculosis; infectious diseases

Special Issue Information

Dear Colleagues,

Mycobacterium tuberculosis elicits a strong immune response from the host to contain the infection. However, the immune-mediated inflammatory response also causes tissue damage, which contributes to the poor outcomes of some forms of the disease.

While susceptible pulmonary tuberculosis (TB) can be considered universally curable with the available treatment regimens, some extrapulmonary forms, such as TB of the central nervous system, still have unacceptable high mortality and disability rates. Insights into the negative impact of an exaggerated immune response on poor outcomes in TB arise from the beneficial effect of corticosteroids on the mortality of TB meningitis, and, to a lesser extent, in other forms of the disease. Likewise, the increased use of tumor necrosis factor-α antagonists and other host-directed therapies to control TB immune-mediated paradoxical reactions also contributes to the evidence on the field. 

Recognizing the importance of research underway, this Special Issue of Pathogens will include papers that contribute to enhance our understanding and implications of the immunopathogenesis for the clinical management of TB—particularly, but not exclusively, of more unfavorable forms of the disease. Bench-to-bedside original research will be welcome. 

Dr. Miguel Santin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • immune response to tuberculosis
  • immunopathogenesis of tuberculosis
  • tuberculosis
  • central nervous tuberculosis
  • tuberculous meningitis

Published Papers

This special issue is now open for submission.
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