Special Issue "Evolutionary Impact of the Noncoding Genome in Higher Organisms—Recent Insights Obtained from the Molecular and Cellular Level to Systems Biology"

A special issue of Non-Coding RNA (ISSN 2311-553X).

Deadline for manuscript submissions: 15 December 2023 | Viewed by 132

Special Issue Editor

Department of Cardiology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany
Interests: cardiovascular diseases; immunopathogenesis; immunogenetics; molecular virology; noncoding human genome; nucleic acid-based therapeutics; RNA interference
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is well known that 99% of the human genome does not encode proteins, but is transcriptionally active and gives rise to a broad spectrum of noncoding RNAs (ncRNAs) with complex regulatory and structural functions. The striking observation of a steeply increasing fraction of ncRNAs, in contrast to an only modest increase in the number of protein-coding genes, during evolution from simple organisms to humans, suggests an overwhelming role of ncRNAs arising from the noncoding genome in health and diseases. Importantly, however, ncRNAs can also be targets or tools of novel therapeutic strategies. Thus, RNA interference-mediating siRNAs are highly versatile novel ‘general purpose’ tools for the silencing of essentially any protein-coding or noncoding gene.

Research into the vast realm of the noncoding genome thus leads to fundamentally new therapeutic strategies based on profoundly enhanced understanding of genome complexity. Beyond established knowledge in the field, this Special Issue aims to address remaining knowledge gaps and discuss newly emerging questions and concepts of research. Contributions will include work from neurosciences (brain research, neurological diseases, anthropology), immunology/genetics, and nucleic acid biochemistry, along with the intersections of these disciplines.

We look forward to colleagues illuminating unsolved questions: Have advanced immune systems incorporated evolutionary recent noncoding genomic regions to improve and balance their response to complex environmental  and endogenous challenges? Is noncoding genome evolution causally linked to brain evolution and may it explain critical differences between otherwise similar primate species? How many molecular players and levels of human genome complexity are still unknown to us? 

You may choose our Joint Special Issue in Cells.

Prof. Dr. Wolfgang Poller
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


cell biology

immune cell functions


noncoding genome


human evolution

brain evolution

brain-immune system interactions

nucleic acid-based therapeutics

RNA interference

Published Papers

This special issue is now open for submission.
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