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Nanomaterials
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Nanostructured Biomaterials for Tissue Repair and Anti-infection
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Nanostructured Biomaterials for Tissue Repair and Anti-infection

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 4156

Special Issue Editors

Prof. Dr. Xuanyong Liu

E-Mail Website
Guest Editor
Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Interests: biomaterials; titanium and its alloys; magnesium alloys; polyether ether ketone ketone; surfaces and interfaces; tissue engineering
Dr. Jiajun Qiu

E-Mail Website1 Website2
Assistant Guest Editor
Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China
Interests: biomaterials; titanium and its alloys; graphene; surfaces and interfaces; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomaterials play a vital role in regenerative medicine, aiming to regenerate and replace lost/dysfunctional tissues. Nanotechnology is a powerful tool in modern materials science and able to incorporate biomimicry at the nanoscale in biomaterials. Due to the advantage of nanoscale features, nanostructured biomaterials show enhanced biocompatibilities, such as cell adhesion, proliferation and differentiation. In recent years, various types of nanostructured biomaterials have been developed and many surface modification techniques have been adopted to produce nano-functionalized biomaterials surface. These nanostructured biomaterials exhibit promising applications in biomedical fields.

This Special Issue focuses on the latest research developments of nanostructured biomaterials for tissue repair and anti-infection purposes. We invite authors to contribute original research articles and review articles covering the current progress on nanostructured biomaterials for tissue repair and preventing infection. The potential topics include, but are not limited to, the fabrication, characterization, and properties of biomaterials such as ceramics, metals, and polymers with nanostructured surfaces.

Prof. Dr. Xuanyong Liu
Dr. Jiajun Qiu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • nanostructures
  • tissue repair
  • anti-infection
  • nanotechnology
  • surface nano-functionalization
  • biocompatibility
  • antibacterial

Published Papers (4 papers)

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Editorial

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2 pages, 153 KiB  
Editorial
Nanostructured Biomaterials for Tissue Repair and Anti-Infection
by Jiajun Qiu and Xuanyong Liu
Nanomaterials 2022, 12(9), 1573; https://doi.org/10.3390/nano12091573 - 06 May 2022
Cited by 1 | Viewed by 1122
Abstract
Biomaterials play a vital role in regenerative medicine, aiming to regenerate and replace lost/dysfunctional tissues [...] Full article
(This article belongs to the Special Issue Nanostructured Biomaterials for Tissue Repair and Anti-infection)

Research

Jump to: Editorial

15 pages, 8835 KiB  
Article
Nanosurface Texturing for Enhancing the Antibacterial Effect of Biodegradable Metal Zinc: Surface Modifications
by Enmao Xiang, Corey S. Moran, Sašo Ivanovski and Abdalla Abdal-hay
Nanomaterials 2023, 13(13), 2022; https://doi.org/10.3390/nano13132022 - 07 Jul 2023
Cited by 4 | Viewed by 1256
Abstract
Zinc (Zn) as a biodegradable metal has attracted research interest for bone reconstruction, with the aim of eliminating the need for a second removal surgery and minimizing the implant-to-bone transfer of stress-shielding to maintain bone regeneration. In addition, Zn has been shown to [...] Read more.
Zinc (Zn) as a biodegradable metal has attracted research interest for bone reconstruction, with the aim of eliminating the need for a second removal surgery and minimizing the implant-to-bone transfer of stress-shielding to maintain bone regeneration. In addition, Zn has been shown to have antibacterial properties, particularly against Gram-negative bacteria, and is often used as a surface coating to inhibit bacterial growth and biofilm formation. However, the antibacterial property of Zn is still suboptimal in part due to low Zn ion release during degradation that has to be further improved in order to meet clinical requirements. This work aims to perform an innovative one-step surface modification using a nitric acid treatment to accelerate Zn ion release by increasing surface roughness, thereby endowing an effective antimicrobial property and biofilm formation inhibition. The antibacterial performance against Staphylococci aureus was evaluated by assessing biofilm formation and adhesion using quantitative assays. The surface roughness of acid-treated Zn (Ra ~ 30 nm) was significantly higher than polished Zn (Ra ~ 3 nm) and corresponded with the marked inhibition of bacterial biofilm, and this is likely due to the increased surface contact area and Zn ion accumulation. Overall, surface modification due to nitric acid etching appears to be an effective technique that can produce unique morphological surface structures and enhance the antibacterial properties of biodegradable Zn-based materials, thus increasing the translation potential toward multiple biomedical applications. Full article
(This article belongs to the Special Issue Nanostructured Biomaterials for Tissue Repair and Anti-infection)
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20 pages, 5268 KiB  
Article
Conferring Antioxidant Activity to an Antibacterial and Bioactive Titanium Surface through the Grafting of a Natural Extract
by Francesca Gamna, Seiji Yamaguchi, Andrea Cochis, Sara Ferraris, Ajay. Kumar, Lia Rimondini and Silvia Spriano
Nanomaterials 2023, 13(3), 479; https://doi.org/10.3390/nano13030479 - 25 Jan 2023
Cited by 4 | Viewed by 1554
Abstract
The main unmet medical need of bone implants is multifunctional activity, including their ability to induce rapid and physiological osseointegration, counteract bacterial biofilm formation, and prevent in situ chronic inflammation at the same time. This research starts from an already developed c.p. titanium [...] Read more.
The main unmet medical need of bone implants is multifunctional activity, including their ability to induce rapid and physiological osseointegration, counteract bacterial biofilm formation, and prevent in situ chronic inflammation at the same time. This research starts from an already developed c.p. titanium surface with proven bioactive (in vitro hydroxyl apatite precipitation) and antibacterial activities, due to a calcium titanate layer with nano- and micro-scale roughness and loaded with iodine ions. Here, antioxidant ability was added to prevent chronic inflammation by grafting polyphenols of a green tea extract onto the surface, without compromising the other functionalities of the surface. The surface was characterized before and after functionalization through XPS analysis, zeta potential titrations, ion release measurements, in vitro bioactivity tests, SEM and fluorescence microscopy, and Folin–Ciocalteu and biological tests. The presence of grafted polyphenols as a homogeneous layer was proven. The grafted polyphenols maintained their antioxidant ability and were anchored to the surface through the linking action of Ca2+ ions added to the functionalizing solution. Iodine ion release, cytocompatibility towards human mesenchymal stem cells (hMSC), and antibacterial activity were maintained even after functionalization. The antioxidant ability of the functionalized surface was effective in preserving hMSC viability in a chemically induced pro-inflammatory environment, thus showing a scavenger activity towards toxic active species responsible for inflammation. Full article
(This article belongs to the Special Issue Nanostructured Biomaterials for Tissue Repair and Anti-infection)
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24 pages, 5291 KiB  
Article
Synthesis, Characterization and Broad-Spectrum Bactericidal Effects of Ammonium Methyl and Ammonium Ethyl Styrene-Based Nanoparticles
by Silvana Alfei, Debora Caviglia, Gabriella Piatti, Guendalina Zuccari and Anna Maria Schito
Nanomaterials 2022, 12(16), 2743; https://doi.org/10.3390/nano12162743 - 10 Aug 2022
Cited by 8 | Viewed by 1381
Abstract
Untreatable infections, growing healthcare costs, and increasing human mortality due to the rising resistance of bacteria to most of the available antibiotics are global phenomena that urgently require the discovery of new and effective antimicrobial agents. Cationic macromolecules, acting as membrane disruptors, are [...] Read more.
Untreatable infections, growing healthcare costs, and increasing human mortality due to the rising resistance of bacteria to most of the available antibiotics are global phenomena that urgently require the discovery of new and effective antimicrobial agents. Cationic macromolecules, acting as membrane disruptors, are widely studied, and several compounds, including two styrene-based copolymers developed by us (P5 and P7), have proved to possess potent broad-spectrum antibacterial effects, regardless of the resistance profiles of the bacteria. Here, we first reported the synthesis and physicochemical characterization of new cationic nanoparticles (NPs) (CP1 and OP2), obtained by polymerizing the monomers 4-ammoniummethylstyrene (4-AMSTY) and 4-ammoniumethylstyrene (4-AESTY) hydrochlorides, whose structures were designed using the cationic monomers of P5 and P7 as template compounds. The antibacterial activity of CP1 and OP2 was assessed against several Gram-positive and Gram-negative multi-drug resistant (MDR) pathogens, observing potent antibacterial effects for both CP1 (MICs = 0.1–0.8 µM) and OP2 (MICs = 0.35–2.8 µM) against most of the tested isolates. Additionally, time-killing studies carried out with CP1 and OP2 on different strains of the most clinically relevant MDR species demonstrated that they kill pathogens rapidly. Due to their interesting physicochemical characteristics, which could enable their mutual formulation as hydrogels, CP1 and OP2 could represent promising ingredients for the development of novel antibacterial dosage forms for topical applications, capable of overcoming severe infections sustained by bacteria resistant to the presently available antibiotics. Full article
(This article belongs to the Special Issue Nanostructured Biomaterials for Tissue Repair and Anti-infection)
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