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Nanomaterials
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Nanoparticles and Biomacromolecule: Nanotechnology Meets Materials Science
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Nanoparticles and Biomacromolecule: Nanotechnology Meets Materials Science

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 6847

Special Issue Editor

Dr. Gyudo Lee

E-Mail Website
Guest Editor
Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Korea
Interests: biomedical nanotechnology; chromosome biology; bioinspired materials

Special Issue Information

Dear Colleagues,

The nanoparticles that have been synthesized by scientists so far are very diverse and have various properties. Depending on the characteristics of each nanoparticle, spectroscopic analysis techniques have been developed in various ways. Although various studies on the characterization of interactions with biomolecules, the detection of biomolecules, and in vivo applications have been conducted using these nanoparticle-based technologies, access to biomacromolecules remains challenging. This is due to the differences in scale, and it is difficult to characterize biomacromolecules using nanoparticles. Nevertheless, we need to challenge this without hesitation.

On the other hand, by utilizing the various properties of nanoparticles, it is possible to form new complexes through interaction with biomacromolecules. This complex can be linked to the production of in vitro pathological models, making various applications such as drug screening and therapeutic development possible. In addition, the nanoparticle–biomacromolecular complex can be used as a new material for nanomedicines.

The purpose of this Special Issue of Nanomaterials is to present research on the interaction between nanoparticles and biomacromolecules as well as advanced research on new composite fabrication technologies and their applications. The scope of research is wide, ranging from utilizing the various types and characteristics of nanoparticles to study biomacromolecules to biomedical applications that are derived through complex formation. In this Special Issue, we would like to cover the latest interesting and impactful research in this field.

Dr. Gyudo Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • biomacromolecules
  • nanotechnology
  • materials science
  • hydrogel
  • composite materials
  • smart materials
  • biosensing platforms
  • biomedical applications

Published Papers (4 papers)

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Research

15 pages, 5477 KiB  
Article
Tethered Bilayer Lipid Membrane Platform for Screening Triton X-100 Detergent Replacements by Electrochemical Impedance Spectroscopy
by Sue Woon Tan, Negin Gooran, Hye Min Lim, Bo Kyeong Yoon and Joshua A. Jackman
Nanomaterials 2023, 13(5), 874; https://doi.org/10.3390/nano13050874 - 26 Feb 2023
Cited by 3 | Viewed by 1490
Abstract
In light of regulatory considerations, there are ongoing efforts to identify Triton X-100 (TX-100) detergent alternatives for use in the biological manufacturing industry to mitigate membrane-enveloped pathogen contamination. Until now, the efficacy of antimicrobial detergent candidates to replace TX-100 has been tested regarding [...] Read more.
In light of regulatory considerations, there are ongoing efforts to identify Triton X-100 (TX-100) detergent alternatives for use in the biological manufacturing industry to mitigate membrane-enveloped pathogen contamination. Until now, the efficacy of antimicrobial detergent candidates to replace TX-100 has been tested regarding pathogen inhibition in endpoint biological assays or probing lipid membrane disruption in real-time biophysical testing platforms. The latter approach has proven especially useful to test compound potency and mechanism of action, however, existing analytical approaches have been limited to studying indirect effects of lipid membrane disruption such as membrane morphological changes. A direct readout of lipid membrane disruption by TX-100 detergent alternatives would be more practical to obtain biologically relevant information to guide compound discovery and optimization. Herein, we report the use of electrochemical impedance spectroscopy (EIS) to investigate how TX-100 and selected replacement candidates—Simulsol SL 11W (Simulsol) and cetyltrimethyl ammonium bromide (CTAB)—affect the ionic permeability of tethered bilayer lipid membrane (tBLM) platforms. The EIS results revealed that all three detergents exhibited dose-dependent effects mainly above their respective critical micelle concentration (CMC) values while displaying distinct membrane-disruptive behaviors. TX-100 caused irreversible membrane disruption leading to complete solubilization, whereas Simulsol caused reversible membrane disruption and CTAB induced irreversible, partial membrane defect formation. These findings establish that the EIS technique is useful for screening the membrane-disruptive behaviors of TX-100 detergent alternatives with multiplex formatting possibilities, rapid response, and quantitative readouts relevant to antimicrobial functions. Full article
(This article belongs to the Special Issue Nanoparticles and Biomacromolecule: Nanotechnology Meets Materials Science)
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14 pages, 6167 KiB  
Article
Peptide-Protected Gold Nanoclusters Efficiently Ameliorate Acute Contact Dermatitis and Psoriasis via Repressing the TNF-α/NF-κB/IL-17A Axis in Keratinocytes
by Yu Liu, Cong Meng, Yanggege Li, Dongfang Xia, Cao Lu, Jing Lai, Yulu Zhang, Kai Cao, Xueyun Gao and Qing Yuan
Nanomaterials 2023, 13(4), 662; https://doi.org/10.3390/nano13040662 - 08 Feb 2023
Cited by 5 | Viewed by 1521
Abstract
Immune-mediated skin diseases have a high prevalence and seriously affect patients’ quality of life. Gold compounds have been considered promising therapeutic agents in dermatology, but the high incidence of adverse reactions have limited their clinical application. There is a great need to develop [...] Read more.
Immune-mediated skin diseases have a high prevalence and seriously affect patients’ quality of life. Gold compounds have been considered promising therapeutic agents in dermatology, but the high incidence of adverse reactions have limited their clinical application. There is a great need to develop more effective and less toxic gold-based drugs. Gold nanoclusters fabricated by using peptides (pep-AuNCs) have appeared as potential biomedical nanomaterials because of their excellent biocompatibility, ease of fabrication and unique physicochemical properties. Glutathione (GSH) is an endogenous tripeptide and has been used for lightening the skin color. Therefore, we fabricated a well-defined gold nanocluster with GSH as an example to explore the immunomodulatory effect of AuNCs on a TNF-α-treated human keratinocyte cell line (HaCaT) in vitro, the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced irritant contact dermatitis (ICD) model and the oxazolone (OXA)-induced psoriatic model in vivo. The results indicated that topically applied AuNCs successfully attenuated the severity of ICD and psoriasis-like lesions. In vitro and in vivo, AuNCs effectively inhibited the abnormal activation of the NF-κB pathway and the consequent overexpression of proinflammatory cytokines in keratinocytes. In particular, the transactivation of IL-17A, the most important cytokine in psoriasis pathology, was effectively inhibited by AuNCs treatment. In addition, AuNCs did not show any obvious cytotoxicity in HaCaT cells at doses even up to 100 µM and did not induce any irritation in the healthy skin and major organs, which indicated their favorable biosafety. These results indicate that biocompatible pep-AuNCs might be a promising gold-based nanomedicine for the treatment of inflammatory skin diseases. Full article
(This article belongs to the Special Issue Nanoparticles and Biomacromolecule: Nanotechnology Meets Materials Science)
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11 pages, 4010 KiB  
Article
Fast Responsive, Reversible Colorimetric Nanoparticle-Hydrogel Complexes for pH Monitoring
by Yeonjin Kim, Taeha Lee, Minsu Kim, Soojin Park, Jiashu Hu, Kyungwon Lee, Yoochan Hong, Insu Park and Gyudo Lee
Nanomaterials 2022, 12(22), 4081; https://doi.org/10.3390/nano12224081 - 20 Nov 2022
Cited by 3 | Viewed by 2075
Abstract
Hydrogels containing redox-sensitive colorimetric nanoparticles (NPs) have been used to sense ambient pH in many fields owing to their simple and fast visualization capabilities. However, real-time pH monitoring still has limitations due to its poor response rate and irreversibility. Herein, we developed a [...] Read more.
Hydrogels containing redox-sensitive colorimetric nanoparticles (NPs) have been used to sense ambient pH in many fields owing to their simple and fast visualization capabilities. However, real-time pH monitoring still has limitations due to its poor response rate and irreversibility. Herein, we developed a fast responsive colorimetric hydrogel called ferrocene adsorption colorimetric hydrogel (FACH). Ferrocene, an organometallic compound, plays a vital role as an electron transfer mediator (i.e., redox catalyst) within the hydrogel network. FACH shows fast color change performance with high reactivity and penetrability to ambient pH changes. In detail, FACH shows distinct color change within 2 min under various pH conditions from four to eight, with good reliability. The speed for color change of FACH is approximately six times faster than that of previously developed colorimetric hydrogels, suggesting the fastest hydrogel-based colorimetric pH sensor. Furthermore, FACH shows reversibility and repeatability of the redox process, indicating scalable utility as a sustainable pH monitoring platform. Full article
(This article belongs to the Special Issue Nanoparticles and Biomacromolecule: Nanotechnology Meets Materials Science)
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13 pages, 2697 KiB  
Article
Colorimetric Nanoparticle-Embedded Hydrogels for a Biosensing Platform
by Taeha Lee, Changheon Kim, Jiyeon Kim, Jung Bae Seong, Youngjeon Lee, Seokbeom Roh, Da Yeon Cheong, Wonseok Lee, Jinsung Park, Yoochan Hong and Gyudo Lee
Nanomaterials 2022, 12(7), 1150; https://doi.org/10.3390/nano12071150 - 30 Mar 2022
Cited by 7 | Viewed by 3236
Abstract
Hydrogels containing colorimetric nanoparticles have been used for ion sensing, glucose detection, and microbial metabolite analyses. In particular, the rapid chemical reaction owing to both the hydrogel form of water retention and the sensitive color change of nanoparticles enables the rapid detection of [...] Read more.
Hydrogels containing colorimetric nanoparticles have been used for ion sensing, glucose detection, and microbial metabolite analyses. In particular, the rapid chemical reaction owing to both the hydrogel form of water retention and the sensitive color change of nanoparticles enables the rapid detection of target substances. Despite this advantage, the poor dispersibility of nanoparticles and the mechanical strength of nanoparticle–hydrogel complexes have limited their application. In this study, we demonstrate a milliliter agarose gel containing homogeneously synthesized polyaniline nanoparticles (PAni-NPs), referred to as PAni-NP–hydrogel complexes (PNHCs). To fabricate the optimal PNHC, we tested various pH solvents based on distilled water and phosphate-buffered saline and studied the colorimetric response of the PNHC with thickness. The colorimetric response of the prepared PNHC to the changes in the pH of the solution demonstrated excellent linearity, suggesting the possibility of using PNHC as a pH sensor. In addition, it was verified that the PNHC could detect minute pH changes caused by the cancer cell metabolites without cytotoxicity. Furthermore, the PNHC can be stably maintained outside water for approximately 12 h without deformation, indicating that it can be used as a disposable patch-type wearable biosensing platform. Full article
(This article belongs to the Special Issue Nanoparticles and Biomacromolecule: Nanotechnology Meets Materials Science)
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