Advanced Nanotechnology for Biomedical Research: Diagnosis, Drug Delivery and Targeted Therapy

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 1578

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Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Interests: radiation therapy; nanoparticles; MR-linac; proton therapy; cancer therapy
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Special Issue Information

Dear Colleagues,

Nanotechnology has opened up new horizons in the field of biomedical research, spanning areas such as diagnosis, drug delivery, targeted therapy, and beyond. Nanomaterials, boasting multifaceted characteristics, emerge as prime candidates for biomedical applications. Their key attributes, including increased loading capacity, expanded surface area, the potential for inducing reactive oxygen species, and adaptability for surface functionalization, position them at the forefront of innovation.

Recent studies have demonstrated the high efficacy of nanomaterials in diverse biomedical applications, encompassing bioimaging, biosensing, gene delivery, drug delivery, photothermal therapy, hyperthermia, combination therapy, and concurrent diagnostics and therapy (theranostics). Consequently, this Special Issue aims to delve into the pivotal role of nanomaterials in advancing biomedical research.

This Special Issue of Nanomaterials, titled 'Advanced Nanotechnology for Biomedical Research', seeks to assemble original research and review articles that shed light on the synthesis, modification, design, properties, and applications of biomedical nanomaterials in various domains. We cordially invite scientists and engineers from diverse multidisciplinary backgrounds, each with their unique technological expertise, to contribute their work to this Special Issue.

Dr. Abdul K. Parchur
Guest Editor

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Keywords

  • drug delivery
  • targeted therapy
  • cancer nanotherapy
  • nanocarriers
  • diagnosis
  • bioimaging
  • biosensing
  • biomedical nanomaterials

Published Papers (1 paper)

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Research

20 pages, 2131 KiB  
Article
Intracranial Gene Delivery Mediated by Albumin-Based Nanobubbles and Low-Frequency Ultrasound
by Takayuki Koga, Hiroshi Kida, Yutaro Yamasaki, Loreto B. Feril, Jr., Hitomi Endo, Keiji Itaka, Hiroshi Abe and Katsuro Tachibana
Nanomaterials 2024, 14(3), 285; https://doi.org/10.3390/nano14030285 - 30 Jan 2024
Viewed by 1302
Abstract
Research in the field of high-intensity focused ultrasound (HIFU) for intracranial gene therapy has greatly progressed over the years. However, limitations of conventional HIFU still remain. That is, genes are required to cross the blood-brain barrier (BBB) in order to reach the neurological [...] Read more.
Research in the field of high-intensity focused ultrasound (HIFU) for intracranial gene therapy has greatly progressed over the years. However, limitations of conventional HIFU still remain. That is, genes are required to cross the blood-brain barrier (BBB) in order to reach the neurological disordered lesion. In this study, we introduce a novel direct intracranial gene delivery method, bypassing the BBB using human serum albumin-based nanobubbles (NBs) injected through a less invasive intrathecal route via lumbar puncture, followed by intracranial irradiation with low-frequency ultrasound (LoFreqUS). Focusing on both plasmid DNA (pDNA) and messenger RNA (mRNA), our approach utilizes LoFreqUS for deeper tissue acoustic penetration and enhancing gene transfer efficiency. This drug delivery method could be dubbed as the “Spinal Back-Door Approach”, an alternative to the “front door” BBB opening method. Experiments showed that NBs effectively responded to LoFreqUS, significantly improving gene transfer in vitro using U-87 MG cell lines. In vivo experiments in mice demonstrated significantly increased gene expression with pDNA; however, we were unable to obtain conclusive results using mRNA. This novel technique, combining albumin-based NBs and LoFreqUS offers a promising, efficient, targeted, and non-invasive solution for central nervous system gene therapy, potentially transforming the treatment landscape for neurological disorders. Full article
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