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Nanomaterials
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Nanotechnology for Biosensors and Bioelectronics Applications
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Nanotechnology for Biosensors and Bioelectronics Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 4076

Special Issue Editors

Dr. Taek Lee

E-Mail Website
Guest Editor
Department of Chemical Engineering, Kwangwoon University, Seoul, Republic of Korea
Interests: biosensor; bioelectronics
Special Issues, Collections and Topics in MDPI journals
Dr. Sijin Guo

E-Mail Website
Co-Guest Editor
RNA & Targeted Therapeutics, Janssen Research & Development LLC, Johnson & Johnson, Brisbane, CA, USA
Interests: RNA nanotechnology; RNA nanoparticles; RNA nanostructure; RNA therapeutics; oligonucleo-tide; nanomedicine; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Since 2000, advances in nanotechnology have led to rapid developments in the field of biotechnology, medicine and pharmacy. The introduction of a variety of nanomaterials to biosensors and bioelectronic devices has attracted substantial research efforts because of their tremendous characteristics, including the physical, chemical, electrical and electrochemical properties of nanoparticles. In addition to the use of nanomaterials, biosensors and bioelectronics can improve the sensitivity, selectivity, response time and biocompatibility.

This Special Issue aims to compile a set of original research papers and review papers representing part of the depth of current research on recent advances in biosensors and bioelectronics based on nanomaterials.

Here, we cordially invite you to contribute original research papers aligned with these themes, in order to advance and improve the state-of-the-art in nanoparticle-based biosensors and biomedical devices that lead to new opportunities, approaches and solutions to next-generation biomedical application and novel biosensor challenges.

Dr. Taek Lee
Dr. Sijin Guo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • biomedical devices
  • nanoparticles
  • nanobiosensors
  • biochip
  • bioelectronics

Published Papers (2 papers)

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Research

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16 pages, 4618 KiB  
Article
Structure-Function Studies of Glucose Oxidase in the Presence of Carbon Nanotubes and Bio-Graphene for the Development of Electrochemical Glucose Biosensors
by Christina Alatzoglou, Eleni I. Tzianni, Michaela Patila, Maria G. Trachioti, Mamas I. Prodromidis and Haralambos Stamatis
Nanomaterials 2024, 14(1), 85; https://doi.org/10.3390/nano14010085 - 28 Dec 2023
Viewed by 827
Abstract
In this work, we investigated the effect of multi-walled carbon nanotubes (MWCNTs) and bio-graphene (bG) on the structure and activity of glucose oxidase (GOx), as well as on the performance of the respective electrochemical glucose biosensors. Various spectroscopic techniques were applied to evaluate [...] Read more.
In this work, we investigated the effect of multi-walled carbon nanotubes (MWCNTs) and bio-graphene (bG) on the structure and activity of glucose oxidase (GOx), as well as on the performance of the respective electrochemical glucose biosensors. Various spectroscopic techniques were applied to evaluate conformational changes in GOx molecules induced by the presence of MWCNTs and bG. The results showed that MWCNTs induced changes in the flavin adenine dinucleotide (FAD) prosthetic group of GOx, and the tryptophan residues were exposed to a more hydrophobic environment. Moreover, MWCNTs caused protein unfolding and conversion of α-helix to β-sheet structure, whereas bG did not affect the secondary and tertiary structure of GOx. The effect of the structural changes was mirrored by a decrease in the activity of GOx (7%) in the presence of MWCNTs, whereas the enzyme preserved its activity in the presence of bG. The beneficial properties of bG over MWCNTs on GOx activity were further supported by electrochemical data at two glucose biosensors based on GOx entrapped in chitosan gel in the presence of bG or MWCNTs. bG-based biosensors exhibited a 1.33-fold increased sensitivity and improved reproducibility for determining glucose over the sweat-relevant concentration range of glucose. Full article
(This article belongs to the Special Issue Nanotechnology for Biosensors and Bioelectronics Applications)
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Review

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21 pages, 4007 KiB  
Review
Recent Developments in DNA-Nanotechnology-Powered Biosensors for Zika/Dengue Virus Molecular Diagnostics
by Goeun Park, Hanbin Park, Sang-Chan Park, Moonbong Jang, Jinho Yoon, Jae-Hyuk Ahn and Taek Lee
Nanomaterials 2023, 13(2), 361; https://doi.org/10.3390/nano13020361 - 16 Jan 2023
Cited by 8 | Viewed by 2882
Abstract
Zika virus (ZIKV) and dengue virus (DENV) are highly contagious and lethal mosquito-borne viruses. Global warming is steadily increasing the probability of ZIKV and DENV infection, and accurate diagnosis is required to control viral infections worldwide. Recently, research on biosensors for the accurate [...] Read more.
Zika virus (ZIKV) and dengue virus (DENV) are highly contagious and lethal mosquito-borne viruses. Global warming is steadily increasing the probability of ZIKV and DENV infection, and accurate diagnosis is required to control viral infections worldwide. Recently, research on biosensors for the accurate diagnosis of ZIKV and DENV has been actively conducted. Moreover, biosensor research using DNA nanotechnology is also increasing, and has many advantages compared to the existing diagnostic methods, such as polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA). As a bioreceptor, DNA can easily introduce a functional group at the 5′ or 3′ end, and can also be used as a folded structure, such as a DNA aptamer and DNAzyme. Instead of using ZIKV and DENV antibodies, a bioreceptor that specifically binds to viral proteins or nucleic acids has been fabricated and introduced using DNA nanotechnology. Technologies for detecting ZIKV and DENV can be broadly divided into electrochemical, electrical, and optical. In this review, advances in DNA-nanotechnology-based ZIKV and DENV detection biosensors are discussed. Full article
(This article belongs to the Special Issue Nanotechnology for Biosensors and Bioelectronics Applications)
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