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Nanomaterials
Special Issues
Nanoprobes and Nanoagents for Biomedical Applications
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Nanoprobes and Nanoagents for Biomedical Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 7675

Special Issue Editors

Prof. Dr. Qingqing Miao

E-Mail Website
Guest Editor
Medical College, Soochow University, Suzhou 215123, China
Interests: probe design; molecular imaging
Prof. Dr. Jingchao Li

E-Mail Website
Guest Editor
College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China
Interests: cancer therapy; immunotherapy; drug delivery systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomaterials provide great opportunities for early diagnosis and precise therapy of diseases. This Special Issue aims to introduce recent advances and breakthroughs in nanoprobes or nanoagents, highlighting probe fabrication, design methodologies, and applications in the diagnostic and therapeutic field. Current relevant, high-impact topics or directions, as well as perspectives and guidelines, are preferred.

It is our pleasure to invite you to submit a manuscript to this Special Issue which provides an excellent opportunity to publish your latest advances in the relevant research fields. Submissions of communications, full papers, mini reviews, and reviews are all welcomed. We look forward to your contributions and fruitful discussions.

Research areas may include (but are not limited to) the following: smart activatable nanoprobes for molecular imaging (optical imaging, MRI, etc.); multimodal imaging; advanced nanoagents for theranostics; organic/inorganic functional nanocomposites for cancer therapy; advanced nanomaterials for antibacterial applications.

We look forward to receiving your contributions.

Prof. Dr. Qingqing Miao
Prof. Dr. Jingchao Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanoprobes
  • Optical imaging
  • Activatable probe
  • Multimodal imaging
  • Therapy
  • Immunotherapy
  • Theranostics
  • Antibacterial

Published Papers (3 papers)

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Research

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13 pages, 4506 KiB  
Article
Rational Constructed Ultra-Small Iron Oxide Nanoprobes Manifesting High Performance for T1-Weighted Magnetic Resonance Imaging of Glioblastoma
by Xiangyan Wang, Lei Chen, Jianxian Ge, Mohammad Javad Afshari, Lei Yang, Qingqing Miao, Ruixue Duan, Jiabin Cui, Chunyi Liu, Jianfeng Zeng, Jian Zhong and Mingyuan Gao
Nanomaterials 2021, 11(10), 2601; https://doi.org/10.3390/nano11102601 - 2 Oct 2021
Cited by 8 | Viewed by 2519
Abstract
Precise diagnosis and monitoring of cancer depend on the development of advanced technologies for in vivo imaging. Owing to the merits of outstanding spatial resolution and excellent soft-tissue contrast, the application of magnetic resonance imaging (MRI) in biomedicine is of great importance. Herein, [...] Read more.
Precise diagnosis and monitoring of cancer depend on the development of advanced technologies for in vivo imaging. Owing to the merits of outstanding spatial resolution and excellent soft-tissue contrast, the application of magnetic resonance imaging (MRI) in biomedicine is of great importance. Herein, Angiopep-2 (ANG), which can simultaneously help to cross the blood-brain barrier and target the glioblastoma cells, was rationally combined with the 3.3 nm-sized ultra-small iron oxide (Fe3O4) to construct high-performance MRI nanoprobes (Fe3O4-ANG NPs) for glioblastoma diagnosis. The in vitro experiments show that the resultant Fe3O4-ANG NPs not only exhibit favorable relaxation properties and colloidal stability, but also have low toxicity and high specificity to glioblastoma cells, which provide critical prerequisites for the in vivo tumor imaging. Furthermore, in vivo imaging results show that the Fe3O4-ANG NPs exhibit good targeting ability toward subcutaneous and orthotopic glioblastoma model, manifesting an obvious contrast enhancement effect on the T1-weighted MR image, which demonstrates promising potential in clinical application. Full article
(This article belongs to the Special Issue Nanoprobes and Nanoagents for Biomedical Applications)
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Review

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18 pages, 3370 KiB  
Review
Recent Advances in Engineering Nanomedicines for Second Near-Infrared Photothermal-Combinational Immunotherapy
by Fengshuo Wang, Jingyi Zhu, Yongtao Wang and Jingchao Li
Nanomaterials 2022, 12(10), 1656; https://doi.org/10.3390/nano12101656 - 12 May 2022
Cited by 12 | Viewed by 2599
Abstract
Immunotherapy has emerged as one of the major strategies for cancer treatment. Unlike conventional therapeutic methods, immunotherapy can treat both primary and distant metastatic tumors through triggering systematic antitumor immune responses and can even prevent tumor recurrence after causing the formation of immune [...] Read more.
Immunotherapy has emerged as one of the major strategies for cancer treatment. Unlike conventional therapeutic methods, immunotherapy can treat both primary and distant metastatic tumors through triggering systematic antitumor immune responses and can even prevent tumor recurrence after causing the formation of immune memory. However, immunotherapy still has the issues of low patient response rates and severe immune-related adverse events in clinical practices. In this regard, the combination of nanomedicine-mediated therapy with immunotherapy can modulate a tumor immunosuppressive microenvironment and thus amplify antitumor immunity. In particular, second near-infrared (NIR-II) photothermal therapy (PTT), which utilizes light conversions to generate heat for killing cancer cells, has shown unique advantages in combining with immunotherapy. In this review, the recent progress of engineering nanomedicines for NIR-II PTT combinational immunotherapy is summarized. The role of nanomedicine-mediated NIR-II PTT in inducing immunogenic cell death and reprogramming the tumor immunosuppressive microenvironment for facilitating immunotherapy are highlighted. The development of NIR-II-absorbing organic and inorganic nonmetal and inorganic metal nanomedicines for the NIR-II PTT combinational immunotherapy of cancer is also introduced in detail. Lastly, the current challenges and future perspectives of these nanomedicines for combinational immunotherapy are proposed. Full article
(This article belongs to the Special Issue Nanoprobes and Nanoagents for Biomedical Applications)
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11 pages, 600 KiB  
Review
Metal Nanoparticles against Viruses: Possibilities to Fight SARS-CoV-2
by Marcelly Chue-Gonçalves, Giovana N. Pereira, Lígia C. Faccin-Galhardi, Renata K. T. Kobayashi and Gerson Nakazato
Nanomaterials 2021, 11(11), 3118; https://doi.org/10.3390/nano11113118 - 19 Nov 2021
Cited by 12 | Viewed by 3539
Abstract
In view of the current Coronavirus Disease 2019 (COVID-19) pandemic outbreak, the research community is focusing on development of diagnostics, treatment, and vaccines to halt or reverse this scenario. Although there are already various vaccines available, adaptive mutations in the SARS-CoV-2 genome can [...] Read more.
In view of the current Coronavirus Disease 2019 (COVID-19) pandemic outbreak, the research community is focusing on development of diagnostics, treatment, and vaccines to halt or reverse this scenario. Although there are already various vaccines available, adaptive mutations in the SARS-CoV-2 genome can alter its pathogenic potential and, at the same time, increase the difficulty of developing drugs or immunization by vaccines. Nanotechnology carries a potential to act in all stages in fighting this viral disease, with several possibilities of strategies such as applying nanoparticles directly as antivirals in delivery systems against these viruses or incorporating them in materials, with power of achievement in therapeutics, vaccines and prevention. In this paper, we review and bring insights of recent studies using metal nanocomposites as antivirals against coronavirus and structurally similar viruses. Full article
(This article belongs to the Special Issue Nanoprobes and Nanoagents for Biomedical Applications)
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