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Nanomaterials
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Nanoparticles for Combination Therapies
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Nanoparticles for Combination Therapies

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 2813

Special Issue Editor

Prof. Dr. David Sánchez-García

E-Mail Website
Guest Editor
Grup d’Enginyeria de Materials, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain
Interests: pyrrole macrocycles for imaging and theranostics; nanoparticles for sensing applications and drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The treatment of complex diseases such as cancer requires innovative approaches. The combined administration of multiple drugs, including small-molecule drugs and biomolecules such as RNA, has emerged as a very promising strategy with many applications for the treatment of genetic disorders and cancer. The implementation of such therapies requires the delivery of the correct combination of drugs to a specific cellular target, minimizing undesirable side-effects. This Special Issue is open to articles and reviews presenting new advances in the application of nanodevices and nanomedicines intended for combination therapies dealing with:

  • Design and preparation of polymeric or hybrid nanodevices and nanocarriers.
  • Decoration of the nanoparticles using bio-conjugation techniques.
  • Assessment of the stability, biocompatibility and safety of nanodevices and nanomedicines.
  • Study of the delivery of drugs and RNA in vitro and in vivo.

Prof. Dr. David Sánchez-García
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymeric nanoparticles
  • mesoporous silica nanoparticles
  • hybrid nanoparticles
  • RNA delivery
  • codelivery systems
  • multiple drug resistance (MDR)
  • tumor marker detection
  • PDT

Published Papers (2 papers)

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Research

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21 pages, 5336 KiB  
Article
Development of pH-Sensitive Magnetoliposomes Containing Shape Anisotropic Nanoparticles for Potential Application in Combined Cancer Therapy
by Ana Rita F. Pacheco, Beatriz D. Cardoso, Ana Pires, André M. Pereira, João P. Araújo, Violeta M. Carvalho, Raquel O. Rodrigues, Paulo J. G. Coutinho, Teresa Castelo-Grande, Paulo A. Augusto, Domingos Barbosa, Rui A. Lima, Senhorinha F. C. F. Teixeira, Ana Rita O. Rodrigues and Elisabete M. S. Castanheira
Nanomaterials 2023, 13(6), 1051; https://doi.org/10.3390/nano13061051 - 15 Mar 2023
Cited by 6 | Viewed by 2419
Abstract
Late diagnosis and systemic toxicity associated with conventional treatments make oncological therapy significantly difficult. In this context, nanomedicine emerges as a new approach in the prevention, diagnosis and treatment of cancer. In this work, pH-sensitive solid magnetoliposomes (SMLs) were developed for controlled release [...] Read more.
Late diagnosis and systemic toxicity associated with conventional treatments make oncological therapy significantly difficult. In this context, nanomedicine emerges as a new approach in the prevention, diagnosis and treatment of cancer. In this work, pH-sensitive solid magnetoliposomes (SMLs) were developed for controlled release of the chemotherapeutic drug doxorubicin (DOX). Shape anisotropic magnetic nanoparticles of magnesium ferrite with partial substitution by calcium (Mg0.75Ca0.25Fe2O4) were synthesized, with and without calcination, and their structural, morphological and magnetic properties were investigated. Their superparamagnetic properties were evaluated and heating capabilities proven, either by exposure to an alternating magnetic field (AMF) (magnetic hyperthermia) or by irradiation with near-infrared (NIR) light (photothermia). The Mg0.75Ca0.25Fe2O4 calcined nanoparticles were selected to integrate the SMLs, surrounded by a lipid bilayer of DOPE:Ch:CHEMS (45:45:10). DOX was encapsulated in the nanosystems with an efficiency above 98%. DOX release assays showed a much more efficient release of the drug at pH = 5 compared to the release kinetics at physiological pH. By subjecting tumor cells to DOX-loaded SMLs, cell viability was significantly reduced, confirming that they can release the encapsulated drug. These results point to the development of efficient pH-sensitive nanocarriers, suitable for a synergistic action in cancer therapy with magnetic targeting, stimulus-controlled drug delivery and dual hyperthermia (magnetic and plasmonic) therapy. Full article
(This article belongs to the Special Issue Nanoparticles for Combination Therapies)
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Review

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19 pages, 8158 KiB  
Review
Polydopamine Nanomaterials for Overcoming Current Challenges in Cancer Treatment
by Shahinur Acter, Michele Moreau, Robert Ivkov, Akila Viswanathan and Wilfred Ngwa
Nanomaterials 2023, 13(10), 1656; https://doi.org/10.3390/nano13101656 - 17 May 2023
Cited by 9 | Viewed by 2455
Abstract
In efforts to overcome current challenges in cancer treatment, multifunctional nanoparticles are attracting growing interest, including nanoparticles made with polydopamine (PDA). PDA is a nature-inspired polymer with a dark brown color. It has excellent biocompatibility and is biodegradable, offering a range of extraordinary [...] Read more.
In efforts to overcome current challenges in cancer treatment, multifunctional nanoparticles are attracting growing interest, including nanoparticles made with polydopamine (PDA). PDA is a nature-inspired polymer with a dark brown color. It has excellent biocompatibility and is biodegradable, offering a range of extraordinary inherent advantages. These include excellent drug loading capability, photothermal conversion efficiency, and adhesive properties. Though the mechanism of dopamine polymerization remains unclear, PDA has demonstrated exceptional flexibility in engineering desired morphology and size, easy and straightforward functionalization, etc. Moreover, it offers enormous potential for designing multifunctional nanomaterials for innovative approaches in cancer treatment. The aim of this work is to review studies on PDA, where the potential to develop multifunctional nanomaterials with applications in photothermal therapy has been demonstrated. Future prospects of PDA for developing applications in enhancing radiotherapy and/or immunotherapy, including for image-guided drug delivery to boost therapeutic efficacy and minimal side effects, are presented. Full article
(This article belongs to the Special Issue Nanoparticles for Combination Therapies)
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