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Nanomaterials
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Functional Nanoparticles for Biomedical and Nanomedicine Application
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Functional Nanoparticles for Biomedical and Nanomedicine Application

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 11211

Special Issue Editor

Prof. Dr. Seog-Young Yoon

E-Mail Website
Guest Editor
Structural and Functional Materials Laboratory, School of Materials Science and Engineering, Pusan National University, Busan, Korea
Interests: biocaremics; materials design; characterization; dental materials; biofunctional materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In bio- and nanomedicine, nanoparticles are used for various purposes, providing new functions. They can be used for dental materials such as resin compounds, as well as drug delivery systems such as drug-releasing materials. To achieve the proper properties for use in bio- and nanomedicine applications, it is important to design a material using composition and synthesis methods. Additionally, the material’s behavior after application needs to identify various characterizations.

This Special Issue focuses on functional nanoparticles for biomedical applications, including materials design, synthesis, and characterizations. Additionally, we are interested in biological behaviors according to functionalized nanomaterials. Biological behaviors do not only contain material behavior, but also biological properties such as cell behavior, antibacterial, mineralization, and hypersensitivity. We invite authors of various research fields working in nanomaterials science and engineering, biomaterials, and medical fields for this Special Issue.

Prof. Dr. Seog-Young Yoon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • composite nanomaterials
  • nanoparticles as biomaterials
  • synthesis methods for functional nanoparticles
  • nanomaterials and nanotechnology
  • biomedical nanomaterials

Published Papers (5 papers)

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Research

16 pages, 3737 KiB  
Article
Nanoscale Surface-Enhanced Raman Spectroscopy Investigation of a Polyphenol-Based Plasmonic Nanovector
by Giacomo Nisini, Annalisa Scroccarello, Francesca Ripanti, Claudia Fasolato, Francesco Cappelluti, Angela Capocefalo, Flavio Della Pelle, Dario Compagnone and Paolo Postorino
Nanomaterials 2023, 13(3), 377; https://doi.org/10.3390/nano13030377 - 17 Jan 2023
Cited by 1 | Viewed by 1872
Abstract
The demand for next-generation multifunctional nanovectors, combining therapeutic effects with specific cellular targeting, has significantly grown during the last few years, pursuing less invasive therapy strategies. Polyphenol-conjugated silver nanoparticles (AgNPs) appear as potential multifunctional nanovectors, integrating the biorecognition capability and the antioxidant power [...] Read more.
The demand for next-generation multifunctional nanovectors, combining therapeutic effects with specific cellular targeting, has significantly grown during the last few years, pursuing less invasive therapy strategies. Polyphenol-conjugated silver nanoparticles (AgNPs) appear as potential multifunctional nanovectors, integrating the biorecognition capability and the antioxidant power of polyphenols, the antimicrobial activity of silver, and the drug delivery capability of NPs. We present a spectroscopic and microscopic investigation on polyphenol-synthesized AgNPs, selecting caffeic acid (CA) and catechol (CT) as model polyphenols and using them as reducing agents for the AgNP green synthesis, both in the presence and in the absence of a capping agent. We exploit the plasmonic properties of AgNPs to collect Surface-Enhanced Raman Scattering (SERS) spectra from the nanosized region next to the Ag surface and to characterize the molecular environment in the proximity of the NP, assessing the orientation and tunable deprotonation level of CA, depending on the synthesis conditions. Our results suggest that the SERS investigation of such nanovectors can provide crucial information for their perspective biomedical application. Full article
(This article belongs to the Special Issue Functional Nanoparticles for Biomedical and Nanomedicine Application)
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23 pages, 6009 KiB  
Article
Zein Nanoparticles Containing Arginine-Phenylalanine-Based Surfactants: Stability, Antimicrobial and Hemolytic Activity
by Lourdes Perez, Zakaria Hafidi, Aurora Pinazo, Maria Teresa García, Manuel Martín-Pastor and Francisco Fábio Oliveira de Sousa
Nanomaterials 2023, 13(1), 200; https://doi.org/10.3390/nano13010200 - 02 Jan 2023
Cited by 4 | Viewed by 1716
Abstract
Although cationic surfactants have a remarkable antimicrobial activity, they present an intrinsic toxicity that discourages their usage. In this work novel zein nanoparticles loaded with arginine-phenylalanine-based surfactants are presented. The nanoparticles were loaded with two single polar head (LAM and PNHC12) [...] Read more.
Although cationic surfactants have a remarkable antimicrobial activity, they present an intrinsic toxicity that discourages their usage. In this work novel zein nanoparticles loaded with arginine-phenylalanine-based surfactants are presented. The nanoparticles were loaded with two single polar head (LAM and PNHC12) and two with double amino acid polar head surfactants, arginine-phenylalanine (C12PAM, PANHC12). The formulations were characterized and their stability checked up to 365 days. Furthermore, the antimicrobial and hemolytic activities were investigated. Finally, NMR and molecular docking studies were carried out to elucidate the possible interaction mechanisms of surfactant-zein. The nanoparticles were obtained with satisfactory size, zeta potential and dispersibility. The surfactants containing arginine-phenylalanine residues were found to be more stable. The nanoencapsulation maintained the antimicrobial activities unaltered in comparison to the surfactants’ solutions. These results are in agreement with the NMR and docking findings, suggesting that zein interacts with the surfactants by the aromatic rings of phenylalanine. As a result, the cationic charges and part of the aliphatic chains are freely available to attack the bacteria and fungi, while not available to disrupt the cellular membranes. This approach opens new possibilities for using cationic surfactants and benefits from their extraordinary antimicrobial responses for several applications. Full article
(This article belongs to the Special Issue Functional Nanoparticles for Biomedical and Nanomedicine Application)
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23 pages, 7398 KiB  
Article
The Comparative Performance of Phytochemicals, Green Synthesised Silver Nanoparticles, and Green Synthesised Copper Nanoparticles-Loaded Textiles to Avoid Nosocomial Infections
by Muhammad Farrukh Tahir, Muhammad Zaman Khan, Safira Attacha, Noreen Asim, Muhammad Tayyab, Azam Ali, Jiri Militky and Blanka Tomková
Nanomaterials 2022, 12(20), 3629; https://doi.org/10.3390/nano12203629 - 16 Oct 2022
Cited by 4 | Viewed by 1544
Abstract
In the current study, a sustainable approach was adopted for the green synthesis of silver nanoparticles, green synthesis of copper nanoparticles, and the investigation of the phytochemical and biological screening of bark, leaves, and fruits of Ehretia acuminata (belongs to the family Boraginaceae). [...] Read more.
In the current study, a sustainable approach was adopted for the green synthesis of silver nanoparticles, green synthesis of copper nanoparticles, and the investigation of the phytochemical and biological screening of bark, leaves, and fruits of Ehretia acuminata (belongs to the family Boraginaceae). Subsequently, the prepared nanoparticles and extracted phytochemicals were loaded on cotton fibres. Surface morphology, size, and the presence of antimicrobial agents (phytochemicals and particles) were analysed by scanning electron microscopy, dynamic light scattering, and energy-dispersive X-ray spectroscopy. The functional groups and the presence of particles (copper and silver) were found by FTIR and XRD analyses. The coated cotton fibres were further investigated for antibacterial (qualitative and quantitative), antiviral, and antifungal analysis. The study revealed that the herb-encapsulated nanoparticles can be used in numerous applications in the field of medical textiles. Furthermore, the utility of hygienic and pathogenic developed cotton bandages was analysed for the comfort properties regarding air permeability and water vapour permeability. Finally, the durability of the coating was confirmed by measuring the antibacterial properties after severe washing. Full article
(This article belongs to the Special Issue Functional Nanoparticles for Biomedical and Nanomedicine Application)
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13 pages, 2988 KiB  
Article
In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA
by Ayoub Medjmedj, Albert Ngalle-Loth, Rudy Clemençon, Josef Hamacek, Chantal Pichon and Federico Perche
Nanomaterials 2022, 12(14), 2446; https://doi.org/10.3390/nano12142446 - 17 Jul 2022
Cited by 6 | Viewed by 3550
Abstract
Lipid Nanoparticles (LNPs) are a leading class of mRNA delivery systems. LNPs are made of an ionizable lipid, a polyethyleneglycol (PEG)-lipid conjugate and helper lipids. The success of LNPs is due to proprietary ionizable lipids and appropriate helper lipids. Using a benchmark lipid [...] Read more.
Lipid Nanoparticles (LNPs) are a leading class of mRNA delivery systems. LNPs are made of an ionizable lipid, a polyethyleneglycol (PEG)-lipid conjugate and helper lipids. The success of LNPs is due to proprietary ionizable lipids and appropriate helper lipids. Using a benchmark lipid (D-Lin-MC3) we compared the ability of three helper lipids to transfect dendritic cells in cellulo and in vivo. Studies revealed that the choice of helper lipid does not influence the transfection efficiency of immortalized cells but, LNPs prepared with DOPE (dioleylphosphatidylethanolamine) and β-sitosterol were more efficient for mRNA transfection in murine dendritic cells than LNPs containing DSPC (distearoylphosphatidylcholine). This higher potency of DOPE and β-sitosterol LNPs for mRNA expression was also evident in vivo but only at low mRNA doses. Overall, these data provide valuable insight for the design of novel mRNA LNP vaccines. Full article
(This article belongs to the Special Issue Functional Nanoparticles for Biomedical and Nanomedicine Application)
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20 pages, 5573 KiB  
Article
Galactomannan-Decorated Lipidic Nanocarrier for Gene Supplementation Therapy in Fabry Disease
by Julen Rodríguez-Castejón, Itziar Gómez-Aguado, Marina Beraza-Millor, María Ángeles Solinís, Ana del Pozo-Rodríguez and Alicia Rodríguez-Gascón
Nanomaterials 2022, 12(14), 2339; https://doi.org/10.3390/nano12142339 - 08 Jul 2022
Cited by 2 | Viewed by 2009
Abstract
Gene supplementation therapy with plasmid DNA (pDNA) represents one of the most promising strategies for the treatment of monogenic diseases such as Fabry disease (FD). In the present work, we developed a solid lipid nanoparticles (SLN)-based non-viral vector with a size below 100 [...] Read more.
Gene supplementation therapy with plasmid DNA (pDNA) represents one of the most promising strategies for the treatment of monogenic diseases such as Fabry disease (FD). In the present work, we developed a solid lipid nanoparticles (SLN)-based non-viral vector with a size below 100 nm, and decorated with galactomannan (GM) to target the liver as an α-Galactosidase A (α-Gal A) production factory. After the physicochemical characterization of the GM-SLN vector, cellular uptake, transfection efficacy and capacity to increase α-Gal A activity were evaluated in vitro in a liver cell line (Hep G2) and in vivo in an animal model of FD. The vector showed efficient internalization and it was highly efficient in promoting protein synthesis in Hep G2 cells. Additionally, the vector did not show relevant agglutination of erythrocytes and lacked hemolytic activity. After the systemic administration to Fabry mice, it achieved clinically relevant α-Gal A activity levels in plasma, liver, and other organs, importantly in heart and kidneys, two of the most damaged organs in FD. This work shows the potential application of GM-decorated lipidic nanocarries for the treatment of FD by pDNA-based gene augmentation. Full article
(This article belongs to the Special Issue Functional Nanoparticles for Biomedical and Nanomedicine Application)
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