Nanoscale Coordination Polymers

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 7365

Special Issue Editor


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Guest Editor
1. Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain
2. Departament de Química, Universitat Autónoma de Barcelona, Campus UAB, Cerdanyola del Vallès, 08193 Barcelona, Spain
Interests: coordination polymers; nanoparticles; nanomedicine; theranostics; drug delivery systems; bioimaging
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Special Issue Information

Dear Colleagues,

Coordination polymers (CPs) have recently emerged as an interesting class of hybrid materials comprised of organic bridging ligands coordinatively bound to metal-connecting points. During the last decade, there has been a tremendous increase in the use of CPs for numerous applications and interest in catalysis, nonlinear optics, energy storage, biomedicine, or environmental remediation. In particular, the exponential growth in the development of many new classes of coordination polymers obtained in the nanometer scale range has demonstrated the relevant role of the nanostructuration to obtain novel materials with new and often enhanced properties compared to traditional materials. The miniaturization of CPs down to the nanometre length scale is, therefore, a unique opportunity to develop a new class of highly tailorable nanoscale materials that combine the rich diversity of compositions, structures, and properties of classical metal–organic materials with the obvious advantages of nanomaterials.

One of the main challenges in the field of nanostructured coordination polymers is to develop novel methodologies and better understand the existing ones to fully exploit the limitless number of possible formulations, sizes, and shapes of these materials. Other challenges are related to the use of bio-related molecules as new building-blocks, or the development of the functionalization of these nanostructured coordination polymers with functional species. This last capability is particularly interesting for biological applications because it should allow the biocompatibilization and cell-specific targeting of these nanoscale materials.

In order to demonstrate the impact of nanoscale coordination polymers as versatile and multifunctional materials in different fields, it is important to highlight the numerous contributions of nanotechnology to obtain and improve this new generation of materials using basic concepts from the coordination chemistry, but looking for new and advanced applications in industry and biomedicine. As such, we invite researchers developing nanostructured coordination polymers to increase the basic knowledge and advantages of these new materials in different areas to submit original research articles, as well as review articles, to this Special Issue, in order to provide the readers of Nanomaterials with an updated perspective on the state of the field. Research may include any aspect of the novel synthetic procedure and nanostructuration of coordination polymers, including novel or potential uses in industry (sensors, catalysis, energy storage, etc.) or in biomedicine (drug-delivery systems, biosensors, contrast agents for imaging, etc.). For planned papers, a title and a short abstract can be sent to the Editorial Office for announcement on this website.

Dr. Fernando Novio
Guest Editor

Manuscript Submission Information

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Keywords

  • nanostructured coordination polymers
  • nanoscale metal-organic materials
  • coordination polymer nanoparticles
  • nanomedicine
  • drug delivery
  • bioimaging
  • sensors
  • energy storage

Published Papers (2 papers)

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Research

16 pages, 1877 KiB  
Article
Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy
by Junda Zhang, Vadde Ramu, Xue-Quan Zhou, Carolina Frias, Daniel Ruiz-Molina, Sylvestre Bonnet, Claudio Roscini and Fernando Novio
Nanomaterials 2021, 11(11), 3089; https://doi.org/10.3390/nano11113089 - 16 Nov 2021
Cited by 4 | Viewed by 3552
Abstract
Green light photoactive Ru-based coordination polymer nanoparticles (CPNs), with chemical formula [[Ru(biqbpy)]1.5(bis)](PF6)3 (biqbpy = 6,6′-bis[N-(isoquinolyl)-1-amino]-2,2′-bipyridine; bis = bis(imidazol-1-yl)-hexane), were obtained through polymerization of the trans-[Ru(biqbpy)(dmso)Cl]Cl complex (Complex 1) and bis bridging ligands. The as-synthesized CPNs (50 ± [...] Read more.
Green light photoactive Ru-based coordination polymer nanoparticles (CPNs), with chemical formula [[Ru(biqbpy)]1.5(bis)](PF6)3 (biqbpy = 6,6′-bis[N-(isoquinolyl)-1-amino]-2,2′-bipyridine; bis = bis(imidazol-1-yl)-hexane), were obtained through polymerization of the trans-[Ru(biqbpy)(dmso)Cl]Cl complex (Complex 1) and bis bridging ligands. The as-synthesized CPNs (50 ± 12 nm diameter) showed high colloidal and chemical stability in physiological solutions. The axial bis(imidazole) ligands coordinated to the ruthenium center were photosubstituted by water upon light irradiation in aqueous medium to generate the aqueous substituted and active ruthenium complexes. The UV-Vis spectral variations observed for the suspension upon irradiation corroborated the photoactivation of the CPNs, while High Performance Liquid Chromatography (HPLC) of irradiated particles in physiological media allowed for the first time precisely quantifying the amount of photoreleased complex from the polymeric material. In vitro studies with A431 and A549 cancer cell lines revealed an 11-fold increased uptake for the nanoparticles compared to the monomeric complex [Ru(biqbpy)(N-methylimidazole)2](PF6)2 (Complex 2). After irradiation (520 nm, 39.3 J/cm2), the CPNs yielded up to a two-fold increase in cytotoxicity compared to the same CPNs kept in the dark, indicating a selective effect by light irradiation. Meanwhile, the absence of 1O2 production from both nanostructured and monomeric prodrugs concluded that light-induced cell death is not caused by a photodynamic effect but rather by photoactivated chemotherapy. Full article
(This article belongs to the Special Issue Nanoscale Coordination Polymers)
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13 pages, 4141 KiB  
Article
Robust Copper Metal–Organic Framework-Embedded Polysiloxanes for Biomedical Applications: Its Antibacterial Effects on MRSA and In Vitro Cytotoxicity
by Kihak Gwon, Youngmee Kim, Hyunjun Cho, Seonhwa Lee, So-Hyeon Yang, Sung-Jin Kim and Do Nam Lee
Nanomaterials 2021, 11(3), 719; https://doi.org/10.3390/nano11030719 - 12 Mar 2021
Cited by 25 | Viewed by 3146
Abstract
Polysiloxanes (PSs) have been widely utilized in the industry as lubricants, varnishes, paints, release agents, adhesives, and insulators. In addition, their applications have been expanded to include the development of new biomedical materials. To modify PS for application in therapeutic purposes, a flexible [...] Read more.
Polysiloxanes (PSs) have been widely utilized in the industry as lubricants, varnishes, paints, release agents, adhesives, and insulators. In addition, their applications have been expanded to include the development of new biomedical materials. To modify PS for application in therapeutic purposes, a flexible antibacterial Cu-MOF (metal–organic framework) consisting of glutarate and 1,2-bis(4-pyridyl)ethane ligands was embedded in PS via a hydrosilylation reaction of vinyl-terminated and H-terminated PSs at 25 °C. The bactericidal activities of the resulting Cu-MOF-embedded PS (PS@Cu-MOF) and the control polymer (PS) were tested against Escherichia coli, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus. PS@Cu-MOF exhibited more than 80% bactericidal activity toward the tested bacteria at a concentration of 100 μg⋅mL−1 and exhibited a negligible cytotoxicity toward mouse embryonic fibroblasts at the same concentration. Release tests of the Cu(II) ion showed PS@Cu-MOF to be particularly stable in a phosphate-buffered saline solution. Furthermore, its physical and thermal properties, including the phase transition, rheological measurements, swelling ratio, and thermogravimetric profile loss, were similar to those of the control polymer. Moreover, the low cytotoxicity and bactericidal activities of PS@Cu-MOF render it a promising candidate for use in medicinal applications, such as in implants, skin-disease treatment, wound healing, and drug delivery. Full article
(This article belongs to the Special Issue Nanoscale Coordination Polymers)
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