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Nanomaterials
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Micro/Nanostructured Surfaces for Cell Adhesion Control
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Micro/Nanostructured Surfaces for Cell Adhesion Control

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 12752

Special Issue Editors

Dr. Barbara Cortese

E-Mail Website
Guest Editor
CNR-Institute of Nanotechnology, 00185 Rome, Italy
Interests: biomechanics; biophysics; calcium; cell; cell adhesion; cell mechanics; cell signalling; extracellular matrix; morphology; nanotechnology; reactive oxygen species
Dr. Ilaria Elena Palamà

E-Mail Website
Guest Editor
CNR Nanotec-Istituto di Nanotecnologia, Via Monteroni, c/o Campus Ekotecne, 73100 Lecce, Italy
Interests: drug delivery; gene delivery; leukemia cancer cells; nanomedicine; nanocarriers; nano-delivery

Special Issue Information

Dear Colleagues,

Cell migration represents a key event in many physiological and/or malignant states (i.e., embryogenesis, inflammation, tissue regeneration, and cancer metastasis). Cell migration can be triggered by chemical gradients (chemotaxis), topographic cues (topography or contact guidance), and electrostatic potentials (galvanotaxis). In particular, the directional migration response to substrate rigidity gradients is now a well-known subset of mechanically induced taxis, so-called mechanotaxis or durotaxis.

Cancer cells in their invasive course are subject to alterations present in the mechanical properties of the primary tumor microenvironment they originate from as well as in the tissue where they metastasize. However, little is still known about the complex interplay between the extracellular mechanical environment and the mechanical properties that characterize the dynamic intracellular environment. 

Here, in this present Special Issue, we invite all scientists to contribute with their research to undercover the mechanics of cell adhesion and cell motility manipulation in the dynamic control of adhesion related to the micromechanical environment of the substrate. Original research articles, reviews, or commentary articles are welcome on all aspects related to the potential application of the systematic design of the micromechanical environment of elastic substrates for cell functional regulation. Relevant topics include, but are not limited to, brain tumor cells, epithelial-to-mesenchymal transition, angiogenesis, migration and invasion, resistance to therapy, 2D versus 3D, scaffolds, molecular and cellular heterogeneity, and any other topics related to the mechanical environment.

Dr. Barbara Cortese
Dr. Ilaria Elena Palamà
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

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Research

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23 pages, 5704 KiB  
Article
Transdermal Immunization of Elastic Liposome-Laden Recombinant Chimeric Fusion Protein of P. falciparum (PfMSP-Fu24) Mounts Protective Immune Response
by Ramesh Chaudhari, Nikunj Tandel, Kiran Sahu, Sushmita Negi, Hilal Bashir, Arzu Rupareliya, Ravi PN Mishra, Sarat K. Dalai and Rajeev K. Tyagi
Nanomaterials 2021, 11(2), 406; https://doi.org/10.3390/nano11020406 - 05 Feb 2021
Cited by 12 | Viewed by 2965
Abstract
Transdermal immunization exhibits poor immunogenic responses due to poor permeability of antigens through the skin. Elastic liposomes, the ultradeformable nanoscale lipid vesicles, overcome the permeability issues and prove a versatile nanocarrier for transcutaneous delivery of protein, peptide, and nucleic acid antigens. Elastic liposome-mediated [...] Read more.
Transdermal immunization exhibits poor immunogenic responses due to poor permeability of antigens through the skin. Elastic liposomes, the ultradeformable nanoscale lipid vesicles, overcome the permeability issues and prove a versatile nanocarrier for transcutaneous delivery of protein, peptide, and nucleic acid antigens. Elastic liposome-mediated subcutaneous delivery of chimeric fusion protein (PfMSP-Fu24) of Plasmodium falciparum exhibited improved immunogenic responses. Elastic liposomes-mediated immunization of PfMSP-Fu24 conferred immunity to the asexual blood-stage infection. Present study is an attempt to compare the protective immune response mounted by the PfMSP-Fu24 upon administered through transdermal and intramuscular routes. Humoral and cell-mediated immune (CMI) response elicited by topical and intramuscularly administered PfMSP-Fu24-laden elastic liposomes (EL-PfMSP-Fu24) were compared and normalized with the vehicle control. Sizeable immune responses were seen with the transcutaneously immunized EL-PfMSP-Fu24 and compared with those elicited with intramuscularly administered antigen. Our results show significant IgG isotype subclass (IgG1and IgG3) response of specific antibody levels as well as cell-mediated immunity (CMI) activating factor (IFN-γ), a crucial player in conferring resistance to blood-stage malaria in mice receiving EL-PfMSP-Fu24 through transdermal route as compared to the intramuscularly administered formulation. Heightened immune response obtained by the vaccination of EL-PfMSP-Fu24 was complemented by the quantification of the transcript (mRNA) levels cell-mediated (IFN-γ, IL-4), and regulatory immune response (IL-10) in the lymph nodes and spleen. Collectively, elastic liposomes prove their immune-adjuvant property as they evoke sizeable and perdurable immune response against PfMSP-Fu24 and justify its potential for the improved vaccine delivery to inducing both humoral and CM immune response. Full article
(This article belongs to the Special Issue Micro/Nanostructured Surfaces for Cell Adhesion Control)
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14 pages, 4434 KiB  
Article
Constructing a Sr2+-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation
by Yingqi Wei, Huichang Gao, Lijing Hao, Xuetao Shi and Yingjun Wang
Nanomaterials 2020, 10(9), 1672; https://doi.org/10.3390/nano10091672 - 26 Aug 2020
Cited by 9 | Viewed by 2058
Abstract
Surface topography and chemical characteristics can regulate stem cell proliferation and differentiation, and decrease the bone-healing time. However, the synergetic function of the surface structure and chemical cues in bone-regeneration repair was rarely studied. Herein, a strontium ion (Sr2+)-substituted surface hydroxyapatite [...] Read more.
Surface topography and chemical characteristics can regulate stem cell proliferation and differentiation, and decrease the bone-healing time. However, the synergetic function of the surface structure and chemical cues in bone-regeneration repair was rarely studied. Herein, a strontium ion (Sr2+)-substituted surface hydroxyapatite (HA) hexagon-like microarray was successfully constructed on 3D-plotted HA porous scaffold through hydrothermal reaction to generate topography and chemical dual cues. The crystal phase of the Sr2+-substituted surface microarray was HA, while the lattice constant of the Sr2+-substituted microarray increased with increasing Sr2+-substituted amount. Sr2+-substituted microarray could achieve the sustainable release of Sr2+, which could effectively promote osteogenic differentiation of human adipose-derived stem cells (ADSCs) even without osteogenic-induced media. Osteogenic characteristics were optimally enhanced using the higher Sr2+-substituted surface microarray (8Sr-HA). Sr2+-substituted microarray on the scaffold surface could future improve the osteogenic performance of HA porous scaffold. These results indicated that the Sr2+-substituted HA surface hexagon-like microarray on 3D-plotted HA scaffolds had promising biological performance for bone-regeneration repair scaffold. Full article
(This article belongs to the Special Issue Micro/Nanostructured Surfaces for Cell Adhesion Control)
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Review

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36 pages, 2246 KiB  
Review
Static and Dynamic Biomaterial Engineering for Cell Modulation
by Hyung-Joon Park, Hyunsik Hong, Ramar Thangam, Min-Gyo Song, Ju-Eun Kim, Eun-Hae Jo, Yun-Jeong Jang, Won-Hyoung Choi, Min-Young Lee, Heemin Kang and Kyu-Back Lee
Nanomaterials 2022, 12(8), 1377; https://doi.org/10.3390/nano12081377 - 17 Apr 2022
Cited by 11 | Viewed by 3497
Abstract
In the biological microenvironment, cells are surrounded by an extracellular matrix (ECM), with which they dynamically interact during various biological processes. Specifically, the physical and chemical properties of the ECM work cooperatively to influence the behavior and fate of cells directly and indirectly, [...] Read more.
In the biological microenvironment, cells are surrounded by an extracellular matrix (ECM), with which they dynamically interact during various biological processes. Specifically, the physical and chemical properties of the ECM work cooperatively to influence the behavior and fate of cells directly and indirectly, which invokes various physiological responses in the body. Hence, efficient strategies to modulate cellular responses for a specific purpose have become important for various scientific fields such as biology, pharmacy, and medicine. Among many approaches, the utilization of biomaterials has been studied the most because they can be meticulously engineered to mimic cellular modulatory behavior. For such careful engineering, studies on physical modulation (e.g., ECM topography, stiffness, and wettability) and chemical manipulation (e.g., composition and soluble and surface biosignals) have been actively conducted. At present, the scope of research is being shifted from static (considering only the initial environment and the effects of each element) to biomimetic dynamic (including the concepts of time and gradient) modulation in both physical and chemical manipulations. This review provides an overall perspective on how the static and dynamic biomaterials are actively engineered to modulate targeted cellular responses while highlighting the importance and advance from static modulation to biomimetic dynamic modulation for biomedical applications. Full article
(This article belongs to the Special Issue Micro/Nanostructured Surfaces for Cell Adhesion Control)
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21 pages, 673 KiB  
Review
Copper Surfaces in Biofilm Control
by Inês B. Gomes, Manuel Simões and Lúcia C. Simões
Nanomaterials 2020, 10(12), 2491; https://doi.org/10.3390/nano10122491 - 11 Dec 2020
Cited by 27 | Viewed by 3584
Abstract
Biofilms are structures comprising microorganisms associated to surfaces and enclosed by an extracellular polymeric matrix produced by the colonizer cells. These structures protect microorganisms from adverse environmental conditions. Biofilms are typically associated with several negative impacts for health and industries and no effective [...] Read more.
Biofilms are structures comprising microorganisms associated to surfaces and enclosed by an extracellular polymeric matrix produced by the colonizer cells. These structures protect microorganisms from adverse environmental conditions. Biofilms are typically associated with several negative impacts for health and industries and no effective strategy for their complete control/eradication has been identified so far. The antimicrobial properties of copper are well recognized among the scientific community, which increased their interest for the use of these materials in different applications. In this review the use of different copper materials (copper, copper alloys, nanoparticles and copper-based coatings) in medical settings, industrial equipment and plumbing systems will be discussed considering their potential to prevent and control biofilm formation. Particular attention is given to the mode of action of copper materials. The putative impact of copper materials in the health and/or products quality is reviewed taking into account their main use and the possible effects on the spread of antimicrobial resistance. Full article
(This article belongs to the Special Issue Micro/Nanostructured Surfaces for Cell Adhesion Control)
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