Advanced Applications of Nanoparticles in Ophthalmology

Dear Colleagues,

This Special Issue, entitled "Advanced Applications of Nanoparticles in Ophthalmology", presents an overview of the cutting-edge research and innovative breakthroughs in the field of ocular nanomedicine. Nanoparticles have emerged as promising tools with immense potential to revolutionize the diagnosis and treatment of various ocular disorders, addressing the unmet needs and challenges in ophthalmic care.

This Special Issue encompasses a diverse array of topics, beginning with novel nanoparticle design and fabrication techniques tailored to ocular drug delivery. Researchers have made significant strides in developing nanoparticles with optimal size, surface properties, and biocompatibility to ensure effective penetration and sustained release of therapeutics in ocular tissues. Thus, the Special Issue also delves into the role of nanoparticles in improving drug solubility and bioavailability while minimizing systemic side effects, thus enhancing the safety and efficacy of ophthalmic pharmaceuticals. Additionally, the potential of nanoparticles to overcome ocular barriers, such as the blood–retinal barrier, has garnered considerable attention, offering promising avenues for targeted drug delivery in sight-threatening conditions.

Special attention is devoted to the role of in vitro models in the preclinical development of new ophthalmic therapeutic agents, providing valuable insights into drug efficacy, safety, and pharmacokinetics. These models are not only useful in assessing drug interactions, cellular responses, and potential adverse effects in a controlled environment but can also reduce reliance on animal experimentation, offering a more ethical and sustainable approach to ophthalmic drug development.

Furthermore, the application of nanoparticles in gene therapy for ocular genetic disorders is highlighted, showcasing the potential to correct or modify disease-causing mutations and restore visual function. Finally, the safety aspects of nanoparticle-based therapies in ophthalmology are considered.

In conclusion, this Special Issue welcomes research articles and reviews shedding light on the latest progress in nanoparticle-based applications within the field of ophthalmology, which have great potential for enhancing the quality of patient care.

Dr. Simona Sapino
Guest Editor

Manuscript Submission Information

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• nanoparticles
• ocular diseases
• retinopathies
• ophthalmic formulations
• in vitro ocular models