Advances in Nanotoxicology: Health and Safety

Dear Colleagues,

We are pleased to invite you to submit an article to our Special Issue entitled “Advances in Nanotoxicology: Health and Safety”. Nanotoxicology has emerged as a prominent field within toxicology, driven by the urgent need to assess the safety of engineered nanomaterials for both human health and the environment. With the rapid integration of nanoscale materials into various aspects of daily life, such as cosmetics, food packaging, drug delivery systems, therapeutics, and biosensors, the number of individuals exposed to nanomaterials continues to rise. While nanoparticles offer significant benefits and advancements in preventing and treating various disorders, concerns have grown regarding their potential risks to human health and the environment. Consequently, nanotoxicology studies initially focused on understanding the dose–response relationship between nanomaterials and their toxicity using in vitro cell models. Extensive research has evaluated the physicochemical properties of nanomaterials, contributing to the definition of nanotoxicity. However, despite these efforts, there remains a lack of clarity and conflicting data regarding the cytotoxicity and biological fate of identical nanoparticles. This uncertainty suggests that we often fail to identify and control the relevant parameters that determine the toxicity of nanoparticles, both in vitro and in vivo. Achieving a comprehensive understanding of the toxicological impact of nanoparticles necessitates a consideration of the relevant factors and an understanding of nanoparticle interactions with biological systems at the molecular level. This knowledge can enable us to predict and mitigate the potential toxicity associated with novel nanomaterials, facilitating the design of safe, reliable, and efficient nanoparticles for biomedical applications.

This Special Issue aims to compile articles that assess the potential effects of emerging nanomaterials on the environment, evaluate their impact on human health, and elucidate the toxic mechanisms induced by nanoparticles. A comprehensive understanding of the pathophysiological mechanisms triggered by these advanced materials can be achieved by presenting data that consider both nanomaterials' advantages and their adverse effects. Ultimately, this knowledge may contribute to significant advancements in the field of nanomedicine. Submissions focusing on results obtained from preclinical studies or clinical trials are welcomed, as they will provide valuable insights into the potential benefits and risks associated with using nanomaterials in various contexts.

In this Special Issue, original research articles and reviews are welcomed. Research areas may include (but are not limited to) the following:

• Environmental factors as triggers of mechanisms of systemic toxicities;
• In vitro and in vivo experimental models for the evaluation of oxidative stress, DNA, and subcellular damages in pathogenesis of nanoparticle-induced toxicities;
• Role of nanomaterials in medical diagnostics and therapeutics;
• The evaluation of systemic toxicities and mechanism of toxicities induced by nanosized biomaterials;
• Role of natural compounds in prevention and treatment of nanoparticle-induced toxicities;
• Nanoformulation of food ingredients and their safety for human health;
• Nanoparticles as anti-inflammatory and antioxidant agents;
• Nanomedicine in clinical trials.

Prof. Dr. Natalia Krasteva
Prof. Dr. Milena Georgieva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• advanced nanomaterials
• mechanism of nanotoxicity
• nanoformulations as drug delivery systems
• nanomedicine in cancer therapy
• environmental toxicity of nanomaterials