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Nanomaterials
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Applications of Electrospinning-Based 3D Architecture Nanomaterials
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Applications of Electrospinning-Based 3D Architecture Nanomaterials

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 5273

Special Issue Editor

Prof. Dr. Satoshi Fujita

E-Mail Website
Guest Editor
Department of Frontier Fiber Technology and Science, University of Fukui, Fukui 910-8507, Japan
Interests: electrospinning; nanofibers; hydrogels; biomaterials; tissue engineering

Special Issue Information

Dear Colleagues,

Living tissues and organs are formed from different scales of fibrous structures such as intracellular microtubules, extracellular matrices around cells, and their aggregates. Tissue engineering aims to construct such ordered and hierarchical fibrous structures from cells. Among various materials, electrospun nanofibers are expected to be useful as cell scaffold materials because of the facileness of structure control and the availability of various materials. Previously flat fiber sheets have been cut and combined to produce three-dimensional structures, however, in recent, the electrospinning technology enabled to fabricate seamless 3D structures with hierarchically controlled nano- and micro-structures from nonwoven fabrics.

The proposed Special Issue is inviting original articles in form of communications, full papers, and reviews demonstrating the progress in the research fields of 3D and hierarchical structure control technology by the electrospinning toward healthcare and medicinal application, including basic research on 3D electrospinning, nanofiber-based cell constructs, and biological responses on the geometrically-controlled nanofiber-based scaffold.

Prof. Dr. Satoshi Fujita
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrospinning
  • nanofiber
  • 3D fabrication and manufacturing
  • geometrically controlled scaffold
  • hierarchically controlled nano- and micro-structures
  • artificial organs
  • tissue engineering
  • healthcare applications
  • cellular microenvironment

Published Papers (3 papers)

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Research

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15 pages, 4388 KiB  
Article
Three-Dimensional Printer-Assisted Electrospinning for Fabricating Intricate Biological Tissue Mimics
by Komal Raje, Keisuke Ohashi and Satoshi Fujita
Nanomaterials 2023, 13(22), 2913; https://doi.org/10.3390/nano13222913 - 08 Nov 2023
Cited by 1 | Viewed by 857
Abstract
Although regenerative medicine necessitates advanced three-dimensional (3D) scaffolds for organ and tissue applications, creating intricate structures across scales, from nano- to meso-like biological tissues, remains a challenge. Electrospinning of nanofibers offers promise due to its capacity to craft not only the dimensions and [...] Read more.
Although regenerative medicine necessitates advanced three-dimensional (3D) scaffolds for organ and tissue applications, creating intricate structures across scales, from nano- to meso-like biological tissues, remains a challenge. Electrospinning of nanofibers offers promise due to its capacity to craft not only the dimensions and surfaces of individual fibers but also intricate attributes, such as anisotropy and porosity, across various materials. In this study, we used a 3D printer to design a mold with polylactic acid for gel modeling. This gel template, which was mounted on a metal wire, facilitated microfiber electrospinning. After spinning, these structures were treated with EDTA to remove the template and were then cleansed and dried, resulting in 3D microfibrous (3DMF) structures, with average fiber diameters of approximately 1 µm on the outer and inner surfaces. Notably, these structures matched their intended design dimensions without distortion or shrinkage, demonstrating the adaptability of this method for various template sizes. The cylindrical structures showed high elasticity and stretchability with an elastic modulus of 6.23 MPa. Furthermore, our method successfully mimicked complex biological tissue structures, such as the inner architecture of the voice box and the hollow partitioned structure of the heart’s tricuspid valve. Achieving specific intricate shapes required multiple spinning sessions and subsequent assemblies. In essence, our approach holds potential for crafting artificial organs and forming the foundational materials for cell culture scaffolds, addressing the challenges of crafting intricate multiscale structures. Full article
(This article belongs to the Special Issue Applications of Electrospinning-Based 3D Architecture Nanomaterials)
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17 pages, 9724 KiB  
Article
Electrospun Filtering Membrane Designed as Component of Self-Decontaminating Protective Masks
by Nathália Oderich Muniz, Sarah Gabut, Mickael Maton, Pascal Odou, Michèle Vialette, Anthony Pinon, Christel Neut, Nicolas Tabary, Nicolas Blanchemain and Bernard Martel
Nanomaterials 2023, 13(1), 9; https://doi.org/10.3390/nano13010009 - 20 Dec 2022
Cited by 3 | Viewed by 1589
Abstract
The 2019 coronavirus outbreak and worsening air pollution have triggered the search for manufacturing effective protective masks preventing both particulate matter and biohazard absorption through the respiratory tract. Therefore, the design of advanced filtering textiles combining efficient physical barrier properties with antimicrobial properties [...] Read more.
The 2019 coronavirus outbreak and worsening air pollution have triggered the search for manufacturing effective protective masks preventing both particulate matter and biohazard absorption through the respiratory tract. Therefore, the design of advanced filtering textiles combining efficient physical barrier properties with antimicrobial properties is more newsworthy than ever. The objective of this work was to produce a filtering electrospun membrane incorporating a biocidal agent that would offer both optimal filtration efficiency and fast deactivation of entrapped viruses and bacteria. After the eco-friendly electrospinning process, polyvinyl alcohol (PVA) nanofibers were stabilized by crosslinking with 1,2,3,4-butanetetracarboxylic acid (BTCA). To compensate their low mechanical properties, nanofiber membranes with variable grammages were directly electrospun on a meltblown polypropylene (PP) support of 30 g/m2. The results demonstrated that nanofibers supported on PP with a grammage of around only 2 g/m2 presented the best compromise between filtration efficiencies of PM0.3, PM0.5, and PM3.0 and the pressure drop. The filtering electrospun membranes loaded with benzalkonium chloride (ADBAC) as a biocidal agent were successfully tested against E. coli and S. aureus and against human coronavirus strain HCoV-229E. This new biocidal filter based on electrospun nanofibers supported on PP nonwoven fabric could be a promising solution for personal and collective protection in a pandemic context. Full article
(This article belongs to the Special Issue Applications of Electrospinning-Based 3D Architecture Nanomaterials)
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Review

Jump to: Research

23 pages, 9845 KiB  
Review
Electrospinning Inorganic Nanomaterials to Fabricate Bionanocomposites for Soft and Hard Tissue Repair
by Jie Cui, Xiao Yu, Yihong Shen, Binbin Sun, Wanxin Guo, Mingyue Liu, Yujie Chen, Li Wang, Xingping Zhou, Muhammad Shafiq and Xiumei Mo
Nanomaterials 2023, 13(1), 204; https://doi.org/10.3390/nano13010204 - 02 Jan 2023
Cited by 11 | Viewed by 2269
Abstract
Tissue engineering (TE) has attracted the widespread attention of the research community as a method of producing patient-specific tissue constructs for the repair and replacement of injured tissues. To date, different types of scaffold materials have been developed for various tissues and organs. [...] Read more.
Tissue engineering (TE) has attracted the widespread attention of the research community as a method of producing patient-specific tissue constructs for the repair and replacement of injured tissues. To date, different types of scaffold materials have been developed for various tissues and organs. The choice of scaffold material should take into consideration whether the mechanical properties, biodegradability, biocompatibility, and bioresorbability meet the physiological properties of the tissues. Owing to their broad range of physico-chemical properties, inorganic materials can induce a series of biological responses as scaffold fillers, which render them a good alternative to scaffold materials for tissue engineering (TE). While it is of worth to further explore mechanistic insight into the use of inorganic nanomaterials for tissue repair, in this review, we mainly focused on the utilization forms and strategies for fabricating electrospun membranes containing inorganic components based on electrospinning technology. A particular emphasis has been placed on the biological advantages of incorporating inorganic materials along with organic materials as scaffold constituents for tissue repair. As well as widely exploited natural and synthetic polymers, inorganic nanomaterials offer an enticing platform to further modulate the properties of composite scaffolds, which may help further broaden the application prospect of scaffolds for TE. Full article
(This article belongs to the Special Issue Applications of Electrospinning-Based 3D Architecture Nanomaterials)
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