Nano-Biomaterials in Tissue Engineering: Fabrication and Application

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 576

Special Issue Editors


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Guest Editor
School of Engineering, Newcastle University, Newcastle-upon-Tyne NE1 7RU, UK
Interests: engineering bioinspired materials; biomimetic systems; micro-encapsulation approaches; surface functionalisation for tissue engineering; regenerative medicine
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Engineering, Newcastle University, Newcastle-upon-Tyne NE1 7RU, UK
Interests: biomaterials; biocompatibility; biomedical engineering; tissue engineering; bone regeneration; regenerative medicine; biomedical science; biomaterial engineering; nanobiotechnology; wound healing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tissue engineering is a rapidly developing interdisciplinary field dedicated to the development and construction of alternative tissues, and organs. Nano-biomaterials have a wide range of uses in tissue engineering, providing versatile tools for cell targeting, drug delivery, scaffold construction and imaging. The use of nano-biomaterials can greatly promote the development of this field and contribute to the creation of effective tissue regeneration techniques. In particular, nano-biomaterials can facilitate tissue regeneration and repair by promoting cell adhesion, proliferation, and differentiation through interactions with cells or tissues. In addition, nano-biomaterials can be used to construct biomimetic tissue engineering scaffolds, which provide cell localization and guidance to promote tissue formation and functional restoration.

This Special Issue aims to collect the latest findings and progress in the field of nano-biomaterials for tissue engineering. We are pleased to invite authors to contribute original research articles, review articles, or short communications regarding (but not limited to) the following aspects:

  1. Nano-biomaterial fabrication techniques for tissue engineering;
  2. Mechanisms involved in interactions between nano-biomaterials and cells or tissues;
  3. Applications of nano-biomaterials in tissue engineering and regenerative medicine.
Dr. Ana Ferreira-Duarte
Dr. Piergiorgio Gentile

Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • nano-biomaterials
  • scaffold construction
  • cell targeting
  • nanofibers
  • stem cells
  • regenerative medicine

Published Papers (1 paper)

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Review

23 pages, 4941 KiB  
Review
Regeneration in Mice of Injured Skin, Heart, and Spinal Cord by α-Gal Nanoparticles Recapitulates Regeneration in Amphibians
by Uri Galili, Jianming Li and Gary L. Schaer
Nanomaterials 2024, 14(8), 730; https://doi.org/10.3390/nano14080730 - 22 Apr 2024
Viewed by 411
Abstract
The healing of skin wounds, myocardial, and spinal cord injuries in salamander, newt, and axolotl amphibians, and in mouse neonates, results in scar-free regeneration, whereas injuries in adult mice heal by fibrosis and scar formation. Although both types of healing are mediated by [...] Read more.
The healing of skin wounds, myocardial, and spinal cord injuries in salamander, newt, and axolotl amphibians, and in mouse neonates, results in scar-free regeneration, whereas injuries in adult mice heal by fibrosis and scar formation. Although both types of healing are mediated by macrophages, regeneration in these amphibians and in mouse neonates also involves innate activation of the complement system. These differences suggest that localized complement activation in adult mouse injuries might induce regeneration instead of the default fibrosis and scar formation. Localized complement activation is feasible by antigen/antibody interaction between biodegradable nanoparticles presenting α-gal epitopes (α-gal nanoparticles) and the natural anti-Gal antibody which is abundant in humans. Administration of α-gal nanoparticles into injuries of anti-Gal-producing adult mice results in localized complement activation which induces rapid and extensive macrophage recruitment. These macrophages bind anti-Gal-coated α-gal nanoparticles and polarize into M2 pro-regenerative macrophages that orchestrate accelerated scar-free regeneration of skin wounds and regeneration of myocardium injured by myocardial infarction (MI). Furthermore, injection of α-gal nanoparticles into spinal cord injuries of anti-Gal-producing adult mice induces recruitment of M2 macrophages, that mediate extensive angiogenesis and axonal sprouting, which reconnects between proximal and distal severed axons. Thus, α-gal nanoparticle treatment in adult mice mimics physiologic regeneration in amphibians. These studies further suggest that α-gal nanoparticles may be of significance in the treatment of human injuries. Full article
(This article belongs to the Special Issue Nano-Biomaterials in Tissue Engineering: Fabrication and Application)
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