Advances in Natural and Bio-Inspired Nanoparticles for the Treatment of Cardiovascular Diseases

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (1 December 2023) | Viewed by 3304

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Special Issue Editors


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Guest Editor
UFR de Pharmacie, Institut Galien Paris-Saclay, Université Paris-Saclay, CNRS UMR 8612, 92296 Châtenay-Malabry, France
Interests: nanoparticles; nanomedicines; cardiovascular diseases; cardiac ischemia; ischemia/reperfusion injuries; targeted drug delivery
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Guest Editor
“Medical and Pharmaceutical Bionanotechnologies” Laboratory, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, 8 B.P. Hasdeu, 050568 Bucharest, Romania
Interests: targeted drug delivery; functionalized nanoparticles; cytokines; cardiovascular diseases; inflammation; endothelium; monocytes/macrophages; natural and synthetic therapeutic agents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular diseases are a major cause of disability and death worldwide. Despite substantial improvements achieved in the treatment of these diseases, there is still an essential need for drug innovation. With this aim, a large number of therapeutic options have been developed for the management of cardiovascular diseases.

In the last few decades, nanomedicine has emerged as a candidate to either improve therapeutic efficacy or with a diagnostic purpose. Comprising a multitude of materials, biodegradable or non-biodegradable, organic or inorganic, nanomedicine had its first clinical application in the treatment of cancer. Since then, other applications have emerged, such as for infectious, neurological, or inflammatory diseases.

In the cardiovascular field, special attention is given to bioinspired nanomedicine as a novel drug delivery platform to enhance drug biocompatibility, ameliorate pharmacokinetics, and avoid the rapid clearance of the drug. Most natural and bio-inspired nanosystems are cell-derived (e.g., erythrocytes, platelets), extracellular vesicles, viruses or bacteria, proteins (e.g., albumin), and synthetic HDL.

The present Special Issue of the MDPI journal Nanomaterials (Impact Factor 5.7) aims to present comprehensive research outlining the progress in applying bio-inspired nanosystems to improve therapy or diagnosis in the cardiovascular field.

The types of manuscripts accepted are full papers, short communications, reviews, points of view, and methodological articles.

Prof. Dr. Mariana Varna-Pannerec
Prof. Dr. Ille C. Gebeshuber
Dr. Manuela Calin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetic nanoparticles
  • cell nanosystems
  • cardiovascular diseases
  • cardiac ischemia
  • extracellular vesicles
  • surface functionalization
  • HDL
  • cerebral ischemia
  • atherosclerosis
  • targeted delivery

Published Papers (2 papers)

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Editorial

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3 pages, 195 KiB  
Editorial
Advances in Natural and Bio-Inspired Nanoparticles for the Treatment of Cardiovascular Diseases
by Mariana Varna, Manuela Calin and Ille C. Gebeshuber
Nanomaterials 2023, 13(23), 3015; https://doi.org/10.3390/nano13233015 - 24 Nov 2023
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Abstract
Cardiovascular diseases (CVD) is a general term for disorders affecting the heart or blood vessels and represent a major cause of disability and death worldwide [...] Full article

Review

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28 pages, 5923 KiB  
Review
A Review on the Applications of Natural Biodegradable Nano Polymers in Cardiac Tissue Engineering
by Rabia Aziz, Mariarosaria Falanga, Jelena Purenovic, Simona Mancini, Patrizia Lamberti and Michele Guida
Nanomaterials 2023, 13(8), 1374; https://doi.org/10.3390/nano13081374 - 15 Apr 2023
Cited by 4 | Viewed by 1820
Abstract
As cardiac diseases, which mostly result in heart failure, are increasing rapidly worldwide, heart transplantation seems the only solution for saving lives. However, this practice is not always possible due to several reasons, such as scarcity of donors, rejection of organs from recipient [...] Read more.
As cardiac diseases, which mostly result in heart failure, are increasing rapidly worldwide, heart transplantation seems the only solution for saving lives. However, this practice is not always possible due to several reasons, such as scarcity of donors, rejection of organs from recipient bodies, or costly medical procedures. In the framework of nanotechnology, nanomaterials greatly contribute to the development of these cardiovascular scaffolds as they provide an easy regeneration of the tissues. Currently, functional nanofibers can be used in the production of stem cells and in the regeneration of cells and tissues. The small size of nanomaterials, however, leads to changes in their chemical and physical characteristics that could alter their interaction and exposure to stem cells with cells and tissues. This article aims to review the naturally occurring biodegradable nanomaterials that are used in cardiovascular tissue engineering for the development of cardiac patches, vessels, and tissues. Moreover, this article also provides an overview of cell sources used for cardiac tissue engineering, explains the anatomy and physiology of the human heart, and explores the regeneration of cardiac cells and the nanofabrication approaches used in cardiac tissue engineering as well as scaffolds. Full article
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