Ultimate Insight into the COX Inhibition
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (5 September 2021) | Viewed by 5342
Special Issue Editors
Interests: drug design; small molecules; natural compounds; protein targeting; anticancer; antiviral; metabolic disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Non-steroidal analgetics find a wide range of applications due to their high efficacy and largely manageable unwanted effects. The identification and functional definition of COX-1 and COX-2 isozymes, the main targets of these drugs, have contributed to stimulate research in this field. The search of new active molecules and the study of handy drug-releasing devices are currently compelling goals in this area, while addressing the action of a drug by the attribution of peculiar pharmacokinetic properties and the design of innovative light-protected pharmaceutical forms represent two new aspects widely investigated.
This Special Issue aims to highlight the current efforts in pharmaceutical chemistry and pharmacology towards innovative strategies against inflammation. It welcomes works on advanced drug discovery approaches by in silico identification of alternative natural and synthetic COX ligands and on the study of structure–activity relationships and the design of convenient methods for the synthesis of effective agents. Nanotechnology applications and biological evaluation of anti-inflammatory therapies will be considered as well.
Dr. Fedora Grande
Prof. Dr. Antonio Garofalo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Natural and synthetic compounds
- Drug design
- Drug synthesis
- Pharmacophore modelling and dynamic simulations
- Structure–activity relationships
- Target validation
- Metabolic activation
- Hit discovery
- Hit-to-lead optimization
- Analytical techniques and methodologies
- Supramolecular chemistry
- Biological evaluation
- Photo-protective systems
