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Molecules
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Natural Bioactive Molecules and Toxins from Marine and Terrestrial Origin
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Natural Bioactive Molecules and Toxins from Marine and Terrestrial Origin

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 8330

Special Issue Editors

Prof. Dr. Jordi Molgó

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Guest Editor
CEA, INRAE, Institut des Sciences du Vivant Frédéric Joliot, Département Médicaments et Technologies pour la Santé (DMTS), Equipe Mixte de Recherche CNRS n° 9004, Service d’Ingénierie Moléculaire pour la Santé (SIMoS), Université Paris-Saclay, Bâtiment 152, rue de la Biologie, Point courrier 24, F-91191 Gif sur Yvette, France
Interests: natural toxins from marine and terrestrial organisms; voltage-gated ion channels; ligand gated channels; nicotinic acetylcholine receptors; cholinesterases; IP3 receptors; cell signaling; synaptic transmission; neuromuscular transmission; transmitter release
Special Issues, Collections and Topics in MDPI journals
Dr. Olivier P. Thomas

E-Mail Website
Guest Editor
School of Biological and Chemical Sciences, Ryan Institute, University of Galway, Arts and Science Building, University Road, H91 TK33 Galway, Ireland
Interests: marine natural products; invertebrates; marine biodiscovery; marine chemical ecology; biosynthesis; metabolomics
Special Issues, Collections and Topics in MDPI journals
Dr. Denis Servent

E-Mail Website
Guest Editor
CEA, Institut des Sciences du Vivant Frédéric Joliot, Service d’Ingénierie Moléculaire des Protéines (SIMOPRO), Université Paris-Saclay, bâtiment 152, F-91191 Gif-sur-Yvette, France
Interests: toxins from venomous animals; marine phycotoxins; nicotinic acetylcholine receptors; G-protein coupled receptors; voltage-gated ion channels; molecular pharmacology

Special Issue Information

Dear Colleagues,

Natural bioactive molecules and toxins from marine and terrestrial origins hold an outstanding place not only in the development of new drug candidates for human and veterinarian medicine, but also for their eventual toxicological effects on humans and animals. Therefore, particular bioactive chemical entities from natural marine and terrestrial resources can be used unambiguously as bioactive compounds, or as drug lead molecules. The wide-range and important chemical diversity among the natural bioactive molecules has attracted significant consideration for understanding their mechanisms of action and as target tools for particular receptors. This Special Issue aims to attract original research article contributions studying the isolation, purification, and functional and molecular characterization of new natural bioactive molecules and toxins from marine and terrestrial origins, as well as reviews that make substantial advances within this field.

Dr. Jordi Molgó
Dr. Olivier Thomas
Dr. Denis Servent
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Keyword 1 Bioactive Chemical Entities
  • Bioactive marine natural products
  • Dinoflagellate and diatom toxins
  • Marine sponges
  • New marine alkaloids
  • Novel substances from plant material
  • Bioinspired drug design
  • Keyword 2 Bioactive Natural Peptides
  • Cyanobacteria peptides
  • Conus, snake, spider, and scorpion venom peptides
  • Peptide ligands for G-protein-coupled receptors
  • Keyword 3 Biological Activity
  • Ion channels and receptor targets
  • Keyword 4 Pharmacology and Toxicology of Natural Products
  • Structure–activity relationship
  • Exploration of therapeutically relevant molecules

Published Papers (2 papers)

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Research

19 pages, 5817 KiB  
Article
Anticancer Activities of the Quinone-Methide Triterpenes Maytenin and 22-β-hydroxymaytenin Obtained from Cultivated Maytenus ilicifolia Roots Associated with Down-Regulation of miRNA-27a and miR-20a/miR-17-5p
by Camila Hernandes, Lucyene Miguita, Romario Oliveira de Sales, Elisangela de Paula Silva, Pedro Omori Ribeiro de Mendonça, Bruna Lorencini da Silva, Maria de Fatima Guarizo Klingbeil, Monica Beatriz Mathor, Erika Bevilaqua Rangel, Luciana Cavalheiro Marti, Juliana da Silva Coppede, Fabio Daumas Nunes, Ana Maria Soares Pereira and Patricia Severino
Molecules 2020, 25(3), 760; https://doi.org/10.3390/molecules25030760 - 10 Feb 2020
Cited by 15 | Viewed by 3826
Abstract
Natural triterpenes exhibit a wide range of biological activities. Since this group of secondary metabolites is structurally diverse, effects may vary due to distinct biochemical interactions within biological systems. In this work, we investigated the anticancer-related activities of the quinone-methide triterpene maytenin and [...] Read more.
Natural triterpenes exhibit a wide range of biological activities. Since this group of secondary metabolites is structurally diverse, effects may vary due to distinct biochemical interactions within biological systems. In this work, we investigated the anticancer-related activities of the quinone-methide triterpene maytenin and its derivative compound 22-β-hydroxymaytenin, obtained from Maytenus ilicifolia roots cultivated in vitro. Their antiproliferative and pro-apoptotic activities were evaluated in monolayer and three-dimensional cultures of immortalized cell lines. Additionally, we investigated the toxicity of maytenin in SCID mice harboring tumors derived from a squamous cell carcinoma cell line. Both isolated molecules presented pronounced pro-apoptotic activities in four cell lines derived from head and neck squamous cell carcinomas, including a metastasis-derived cell line. The molecules also induced reactive oxygen species (ROS) and down-regulated microRNA-27a and microRNA-20a/miR-17-5p, corroborating with the literature data for triterpenoids. Intraperitoneal administration of maytenin to tumor-bearing mice did not lead to pronounced histopathological changes in kidney tissue, suggesting low nephrotoxicity. The wide-ranging activity of maytenin and 22-β-hydroxymaytenin in head and neck cancer cells indicates that these molecules should be further explored in plant biochemistry and biotechnology for therapeutic applications. Full article
(This article belongs to the Special Issue Natural Bioactive Molecules and Toxins from Marine and Terrestrial Origin)
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16 pages, 657 KiB  
Article
Chemical Diversity of Codium bursa (Olivi) C. Agardh Headspace Compounds, Volatiles, Fatty Acids and Insight into Its Antifungal Activity
by Igor Jerković, Marina Kranjac, Zvonimir Marijanović, Bojan Šarkanj, Ana-Marija Cikoš, Krunoslav Aladić, Sandra Pedisić and Stela Jokić
Molecules 2019, 24(5), 842; https://doi.org/10.3390/molecules24050842 - 27 Feb 2019
Cited by 22 | Viewed by 4136
Abstract
The focus of present study is on Codium bursa collected from the Adriatic Sea. C. bursa volatiles were identified by gas chromatography and mass spectrometry (GC-FID; GC-MS) after headspace solid-phase microextraction (HS-SPME), hydrodistillation (HD), and supercritical CO2 extraction (SC-CO2). The [...] Read more.
The focus of present study is on Codium bursa collected from the Adriatic Sea. C. bursa volatiles were identified by gas chromatography and mass spectrometry (GC-FID; GC-MS) after headspace solid-phase microextraction (HS-SPME), hydrodistillation (HD), and supercritical CO2 extraction (SC-CO2). The headspace composition of dried (HS-D) and fresh (HS-F) C. bursa was remarkably different. Dimethyl sulfide, the major HS-F compound was present in HS-D only as a minor constituent and heptadecane percentage was raised in HS-D. The distillate of fresh C. bursa contained heptadecane and docosane among the major compounds. After air-drying, a significantly different composition of the volatile oil was obtained with (E)-phytol as the predominant compound. It was also found in SC-CO2 extract of freeze-dried C. bursa (FD-CB) as the major constituent. Loliolide (3.51%) was only identified in SC-CO2 extract. Fatty acids were determined from FD-CB after derivatisation as methyl esters by GC-FID. The most dominant acids were palmitic (25.4%), oleic (36.5%), linoleic (11.6%), and stearic (9.0%). FD-CB H2O extract exhibited better antifungal effects against Fusarium spp., while dimethyl sulfoxide (DMSO) extract was better for the inhibition of Penicillium expansum, Aspergillus flavus, and Rhizophus spp. The extracts showed relatively good antifungal activity, especially against P. expansum (for DMSO extract MIC50 was at 50 µg/mL). Full article
(This article belongs to the Special Issue Natural Bioactive Molecules and Toxins from Marine and Terrestrial Origin)
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