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Microwave Irradiation in Organic Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Microwave Chemistry".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 4274

Special Issue Editors


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Guest Editor
INSA Rouen Normandie, Univ. Rouen Normandie, CNRS UMR 6014 COBRA, FR 3038, F-76000 Rouen, France
Interests: chemistry of heterocyclic compounds; microwave-assisted chemistry; sustainable methodologies; green chemistry applied to bioactive compounds: kinase inhibitors; Alzheimer's disease; down syndrome; cancer
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Institut des Sciences Chimiques de Rennes (ISCR), UMR CNRS 6226, Groupe CORINT, Université de Rennes 1 (UR1), Campus de Beaulieu, Bât. 10A, 263 Avesnue du Général Leclerc, CS 74205, 35042 Rennes CEDEX, France
Interests: microwave-assisted organic chemistry and scale-up; “Store Operated Calcium Entry” inhibitors (Orai1) for cancer via Délikine program inhibitors; mitochondrial ion channel inhibitors for cancer; protein kinase (PKs) inhibitors for CNS (Alzheimer’s disease and Down syndrome) via Leucettine program inhibitors; fluorescence probes for studies of molecular mechanisms in cancer biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to announce the launch of a new Special Issue of Molecules on “Microwave Irradiation in Organic Chemistry”.

It is now well established that Irradiation of reaction mixtures under microwaves allows reproducible and safe operating conditions for convenient access to various molecules when traditional multistep processes would need long reaction times and unstable and toxic reagents. Most microwave-assisted processes are performed in a highly efficient manner with regard to time and energy saving and simple manipulation.

Considering that chemists would have to discover sustainable methodologies with high feasibility, high yields, and products of good quality, this Special Issue will present an overview of the current state of the field, future developments, and possibilities for application and association of microwaves with other technologies such as Raman spectroscopy, IR detection, ultrasound-assisted heating, and continuous-flow chemistry.

This Special Issue invites scientists to submit original communications, papers, and reviews describing recent advances in the use of microwaves in the various fields of organic chemistry.

The following topics will be covered:

- Microwave irradiation in organic chemistry;

- Catalysis and microwave irradiation and kinetics effects, mechanistic studies;

- Microwave irradiation and green chemistry, MCR reactions, one-pot processes, use of green solvents;

- Microwave irradiation in medicinal chemistry synthesis of drugs and biomaterials;

- Microwave irradiation for scale-up approaches and industrial process development;

- Microwave irradiation in association with Raman spectroscopy, ultrasound, and continuous-flow techniques.

Prof. Dr. Thierry Besson
Prof. Dr. Jean-Pierre Bazureau
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthetic methodology
  • catalysis
  • kinetics effects
  • mechanistic studies
  • medicinal chemistry
  • biomaterial and material science
  • green chemistry
  • multicomponent reactions (MCR) reactions
  • one-pot processes
  • use of green solvents
  • scale-up approaches and industrial process development

Published Papers (2 papers)

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Research

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12 pages, 2570 KiB  
Article
Microwave Irradiation as a Powerful Tool for the Preparation of n-Type Benzotriazole Semiconductors with Applications in Organic Field-Effect Transistors
by Iván Torres-Moya, Alexandra Harbuzaru, Beatriz Donoso, Pilar Prieto, Rocío Ponce Ortiz and Ángel Díaz-Ortiz
Molecules 2022, 27(14), 4340; https://doi.org/10.3390/molecules27144340 - 06 Jul 2022
Cited by 10 | Viewed by 1725
Abstract
In this work, as an equivocal proof of the potential of microwave irradiation in organic synthesis, a complex pyrazine-decorated benzotriazole derivative that is challenging to prepare under conventional conditions has been obtained upon microwave irradiation, thus efficiently improving the process and yields, dramatically [...] Read more.
In this work, as an equivocal proof of the potential of microwave irradiation in organic synthesis, a complex pyrazine-decorated benzotriazole derivative that is challenging to prepare under conventional conditions has been obtained upon microwave irradiation, thus efficiently improving the process and yields, dramatically decreasing the reaction times and resulting in an environmentally friendly synthetic procedure. In addition, this useful derivative could be applied in organic electronics, specifically in organic field-effect transistors (OFETs), exhibiting the highest electron mobilities reported to date for benzotriazole discrete molecules, of around 10−2 cm2V−1s−1. Full article
(This article belongs to the Special Issue Microwave Irradiation in Organic Chemistry)
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Review

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13 pages, 4065 KiB  
Review
Microwave-Assisted Post-Ugi Reactions for the Synthesis of Polycycles
by Liangliang Song, Lingchao Cai and Erik V. Van der Eycken
Molecules 2022, 27(10), 3105; https://doi.org/10.3390/molecules27103105 - 12 May 2022
Cited by 7 | Viewed by 1873
Abstract
Microwave irradiation and post-Ugi reactions own their respective advantages in comparison with other strategies. The combination of microwave irradiation and post-Ugi reactions shows paramount importance in the construction of polycycles. This minireview outlines the recent developments of microwave-assisted post-Ugi reactions for the synthesis [...] Read more.
Microwave irradiation and post-Ugi reactions own their respective advantages in comparison with other strategies. The combination of microwave irradiation and post-Ugi reactions shows paramount importance in the construction of polycycles. This minireview outlines the recent developments of microwave-assisted post-Ugi reactions for the synthesis of polycycles. Through transition metal-catalyzed or transition metal-free transformations, diverse polycycles are prepared in an efficient, rapid, and step-economical manner. Full article
(This article belongs to the Special Issue Microwave Irradiation in Organic Chemistry)
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