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Application of Microwave Irradiation in Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Microwave Chemistry".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 2027

Special Issue Editor


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Guest Editor
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd., Boston, MA 02125, USA
Interests: organofluorine chemistry; heterogeneous catalysis; heterocyclic chemistry; asymmetric synthesis; catalytic hydrogenation; microwave-assisted organic synthesis; medicinal chemistry
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Special Issue Information

Dear Colleagues,

In recent decades, microwave activation has become a widely applied method in synthetic chemistry to obtain various compounds and materials. Contemporary microwave instruments and reactors provide the essential elements required in all branches of synthetic chemistry, temperature control, reliability, reproducibility, and scalability. Microwave irradiation offers important advantages compared to conventional heating, such as a significant increase in reaction rates accompanied by a decrease in reaction times, increase in the yield and selectivity of target compounds, solvent-free approaches, energy efficiency, and overall simple processes. Microwave activation is widely used in different fields of chemistry, including organic synthesis, catalysis, the preparation of materials, including polymers, zeolites, nanomaterials, metal–organic frameworks, carbon-based materials, or polymer composites. In addition to synthetic chemistry, microwave activation is widely used in other areas as well, such as biotechnology (proteomics, biocatalysis/enzyme reactions, and digestion of biological samples or in bioassay development). Microwave irradiation is also a leading force in green and environmental chemistry, including biomass-related applications (pyrolysis and other form of degradation, or extraction) and waste recycling, water and soil treatment, and environmental remediation. An emerging area of use is when microwaves are applied in combination with other non-traditional activation methods e.g. the the joint use of microwaves with ultrasounds, photo- and electrochemistry, and mechanochemical activation. The aim of this Special Issue is to provide a unified platform where researchers can publish their recent research and developments in the broadly defined field of microwave chemistry.

Prof. Dr. Bela Torok
Guest Editor

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Keywords

  • microwave irradiation
  • microwave-assisted synthesis
  • organic synthesis
  • catalysis
  • nanomaterial synthesis
  • inorganic synthesis
  • flow chemistry
  • solid-state chemistry
  • green chemistry
  • biotechnology
  • biomass
  • waste recycling
  • environmental remediation

Published Papers (1 paper)

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Research

11 pages, 2291 KiB  
Article
An Intramolecular Hydroaminomethylation-Based Approach to Pyrrolizidine Alkaloids under Microwave-Assisted Heating
by Elena Petricci, Simone Zurzolo, Camilla Matassini, Samuele Maramai, Francesca Cardona, Andrea Goti and Maurizio Taddei
Molecules 2022, 27(15), 4762; https://doi.org/10.3390/molecules27154762 - 25 Jul 2022
Cited by 1 | Viewed by 1754
Abstract
A general method for the synthesis of pyrrolizidine derivatives using an intramolecular hydroaminomethylation protocol (HAM) under microwave (MW) dielectric heating is reported. Starting from a 3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-vinylpyrrolidine, MW-assisted intramolecular HAM in the presence of gaseous H2 and CO gave the natural alkaloid hyacinthacine A2 [...] Read more.
A general method for the synthesis of pyrrolizidine derivatives using an intramolecular hydroaminomethylation protocol (HAM) under microwave (MW) dielectric heating is reported. Starting from a 3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-vinylpyrrolidine, MW-assisted intramolecular HAM in the presence of gaseous H2 and CO gave the natural alkaloid hyacinthacine A2 protected as benzyl ether. The same approach gave a lentiginosine analogue starting from the corresponding vinyl N-hydroxypyrrolidine. The nature of the reaction products and the yields were strongly influenced by the relative stereochemistry of the starting pyrrolidines, as well as by the catalyst/ligand employed. The use of ethanol as a solvent provides environmentally friendly conditions, while the ligand/catalyst system can be recovered by separating the alkaloid product with an SCX column and recycling the ethanolic solution. HAM worked up to three times with the recycled catalyst solution without any significant impact on yield. Full article
(This article belongs to the Special Issue Application of Microwave Irradiation in Chemistry)
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