molecules-logo

Journal Browser

Journal Browser

Recent Advances in Eco-Friendly Deep Eutectic Solvents Research: Synthesis, Properties and Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 5196

Special Issue Editors


E-Mail Website
Guest Editor
Equipe MVBV, Institut de Chimie de Nice, Université Cote d’Azur, Nice, France
Interests: solution thermodynamics; ionic liquids; eutectic solvents; liquid-liquid extraction; critical raw materials; natural compounds; biomass valorization

E-Mail Website
Guest Editor
Equipe COrInt, Institut des Sciences chimiques de Rennes - UMR 6226, Université de Rennes 1, Rennes, France
Interests: Deep eutectic solvents; Extraction of natural compounds; Development of extraction processes; Cosmetics; Pharmaceutics

Special Issue Information

Dear Colleagues,

Deep eutectic solvents are currently the subject of intensive research throughout the chemistry and bioengineering community, due to very promising environmentally friendly properties. Based on their mostly natural or non-toxic compounds, and exhibiting exceptional physical chemical properties, they are being applied as promising solvents for a large range of applications, ranging from solubilization of natural compounds, electrochemistry, organic chemistry, to their integration to new chemical and bioengineering processes.

In this context, the Guest Editors propose a Special Issue on deep eutectic solvents dedicated to collecting the most recent advances in this field. Topics of interest include all innovative aspects of the properties and applications of deep eutectic solvents. Physical chemical properties of new systems, intermolecular solvent–solvent or solute–solvent interactions fall within the scope of this issue. Alternative or breakthrough applications of these solvents to existing or new processes such as organic or inorganic synthesis, electrochemistry, extraction and purification of ionic or neutral compounds and bioengineering processes are of significant importance. The combination of both properties and applications of these solvents will shed some inspiring light on the current understanding of these solvents and help gaining insights into the underlying mechanisms in play in such media.  

Dr. Nicolas Papaiconomou
Dr. Ludovic Paquin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Deep eutectic solvents
  • Natural compounds
  • Solvent properties
  • Sustainable development
  • Organic chemistry
  • Inorganic chemistry
  • Electrochemistry
  • Extraction
  • Bioengineering processes

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

17 pages, 3247 KiB  
Article
Extraction of Bioactive Components from Chamaenerion angustifolium (L.) Scop. with Choline Chloride and Organic Acids Natural Deep Eutectic Solvents
by Nikita Tsvetov, Elena Pasichnik, Anna Korovkina and Alevtina Gosteva
Molecules 2022, 27(13), 4216; https://doi.org/10.3390/molecules27134216 - 30 Jun 2022
Cited by 9 | Viewed by 2137
Abstract
Chamaenerion angustifolium (L.) Scop. (fireweed) is a perennial herbaceous plant of the Onagraceae family widely used in folk and scientific medicine. It is a promising source of bioactive components. One of the modern trends in extraction is the use of natural deep eutectic [...] Read more.
Chamaenerion angustifolium (L.) Scop. (fireweed) is a perennial herbaceous plant of the Onagraceae family widely used in folk and scientific medicine. It is a promising source of bioactive components. One of the modern trends in extraction is the use of natural deep eutectic solvents (NADESs) combined with ultrasound-assisted extraction (UAE). However, works devoted to the extraction of biologically active substances from C. angustifolium using NADESs are scarce. The aim of this work is a comprehensive study of UAE of bioactive components from C. angustifolium using NADESs based on choline chloride and malonic, malic, tartaric, and citric acids. The antioxidative properties, total phenols, and flavonoids content were estimated for NADES-based extracts. The reference solvents were water and 90% v/v ethanol. Volatile extracted components were identified using GC-MS. The kinetics of the UAE were studied at 45 °C for 20–180 min with water added to 30 wt% NADES. The power of the ultrasound was 120 W, and the frequency was 40 kHz. It was found that NADES choline chloride + citric acid is more effective for the extraction of bioactive components. For this, NADES UAE conditions were optimized following a Box–Behnken design of the experiment and a response surface methodology. The temperature ranged from 30 to 60 °C, the time of extraction ranged from 20 to 60, and the addition of water ranged from 30 to 70 wt%. We established the optimal extraction conditions: temperature 58 °C, time of extraction 35 min, and 70 wt% water. The obtained results expand the knowledge about the use of NADES for the extraction of biologically active compounds from cheap and available plant raw materials. Full article
Show Figures

Figure 1

19 pages, 2364 KiB  
Article
Improvement of the Solubilization and Extraction of Curcumin in an Edible Ternary Solvent Mixture
by Verena Huber, Laurie Muller, Johnny Hioe, Pierre Degot, Didier Touraud and Werner Kunz
Molecules 2021, 26(24), 7702; https://doi.org/10.3390/molecules26247702 - 20 Dec 2021
Cited by 7 | Viewed by 2586
Abstract
A water-free, ternary solvent mixture consisting of a natural deep eutectic solvent (NADES), ethanol, and triacetin was investigated concerning its ability to dissolve and extract curcumin from Curcuma longa L. To this purpose, 11 NADES based on choline chloride, acetylcholine, and proline were [...] Read more.
A water-free, ternary solvent mixture consisting of a natural deep eutectic solvent (NADES), ethanol, and triacetin was investigated concerning its ability to dissolve and extract curcumin from Curcuma longa L. To this purpose, 11 NADES based on choline chloride, acetylcholine, and proline were screened using UV–vis measurements. A ternary phase diagram with a particularly promising NADES, based on choline chloride and levulinic acid was recorded and the solubility domains of the monophasic region were examined and correlated with the system’s structuring via light scattering experiments. At the optimum composition, close to the critical point, the solubility of curcumin could be enhanced by a factor of >1.5 with respect to acetone. In extraction experiments, conducted at the points of highest solubility and evaluated via HPLC, a total yield of ~84% curcuminoids per rhizome could be reached. Through multiple extraction cycles, reusing the extraction solvent, an enrichment of curcuminoids could be achieved while altering the solution. When counteracting the solvent change, even higher concentrated extracts can be obtained. Full article
Show Figures

Figure 1

Back to TopTop