Probing New and Underexplored Protein-Protein Interactions
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: closed (30 April 2020) | Viewed by 2895
Special Issue Editor
Interests: drug discovery and development; assay design; compound screening; protein–protein interactions; computational medicinal chemistry; cancer; chemical biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Protein-protein interactions (PPIs) are essential for the proper biological function of almost every process that occurs inside a cell. As such, a clear understanding of as many PPIs as possible is key for understanding normal and aberrant cellular signaling. Multiple approaches have been utilized to probe both individual PPIs and larger protein interaction networks. Techniques such as tandem affinity purification, protein–fragment complementation, and coimmunoprecipitation are commonly used to identify protein interaction partners in vitro. Structural biology (NMR, x-ray crystallography, cryo-EM) can determine key intermolecular interactions at the interface of a PPI and identify hotspot regions essential for binding. Combining this structural information with cellular mutation studies provides insight into how disruption of a PPI affects its biological function. In addition, the development of small-molecule PPI inhibitors as chemical probes and potential drugs has greatly enhanced our understanding of the therapeutic potential of PPIs. Finally, in silico methods have proven capable of predicting PPIs and exploring the dynamic changes the protein partners undergo during the binding process. This Special Issue will consider for publication reviews and original research articles that focus on utilizing these and other related techniques to expand our knowledge on new and underexplored PPIs.
Assoc. Prof. M. Kyle Hadden
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Protein-Protein Interactions
- Structural Biology
- Chemical Probes
- In Silico Methods
- Mutational Studies
