Metalloenzymes: Functions and Biomedical Applications
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 739
Special Issue Editors
Interests: structural biology; X-ray crystallography; proteins; protein-ligand complexes
Special Issues, Collections and Topics in MDPI journals
Interests: structural biology; X-ray crystallography
Interests: structural biology; X-ray crystallography; biochemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metalloenzymes are a widespread class of proteins found in all kingdom of life, which utilize a metal ion to promote catalysis. Several studies have been reported on these enzymes clarifying both their structural features and their mechanism of action and highlighting their essential role in fundamental biological activities, such as nucleic acid modification, protein degradation, photosynthesis, water oxidation, and many others. The role of metalloenzymes in these processes makes them central in the outbreak or the progression of many diseases, including cancer, neurodegenerative disorders, diabetes, bacterial infections, and rheumatoid arthritis. As a consequence, these enzymes have become attractive targets for therapeutic interventions, and several high-affinity ligands, able to modulate their activity, have been successfully developed.
The present Special Issue aims to summarize the most important results recently obtained on the functions and biomedical applications of metalloenzymes.
Dr. Vincenzo Alterio
Dr. Katia D'Ambrosio
Dr. Anna Di Fiore
Guest Editors
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Keywords
- drug targets
- inhibitor development
- oxidoreductases
- phosphodiesterases
- peptidases
- hydrolase
- lyases
