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Metalloenzymes: Functions and Biomedical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 652

Special Issue Editors

Institute of Biostructures and Bioimaging-CNR, Via Pietro Castellino 111, 80131 Naples, Italy
Interests: structural biology; X-ray crystallography; proteins; protein-ligand complexes
Special Issues, Collections and Topics in MDPI journals
Dr. Katia D'Ambrosio
E-Mail Website
Guest Editor
Institute of Biostructures and Bioimaging, National Research Council of Italy, Via Mezzocannone 16, 80134 Naples, Italy
Interests: structural biology; X-ray crystallography
Istituto di Biostrutture e Bioimmagini, CNR, Via Pietro Castellino 111, 80131 Napoli, Italy
Interests: structural biology; X-ray crystallography; biochemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metalloenzymes are a widespread class of proteins found in all kingdom of life, which utilize a metal ion to promote catalysis. Several studies have been reported on these enzymes clarifying both their structural features and their mechanism of action and highlighting their essential role in fundamental biological activities, such as nucleic acid modification, protein degradation, photosynthesis, water oxidation, and many others. The role of metalloenzymes in these processes makes them central in the outbreak or the progression of many diseases, including cancer, neurodegenerative disorders, diabetes, bacterial infections, and rheumatoid arthritis. As a consequence, these enzymes have become attractive targets for therapeutic interventions, and several high-affinity ligands, able to modulate their activity, have been successfully developed.

The present Special Issue aims to summarize the most important results recently obtained on the functions and biomedical applications of metalloenzymes.

Dr. Vincenzo Alterio
Dr. Katia D'Ambrosio
Dr. Anna Di Fiore
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • drug targets
  • inhibitor development
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  • phosphodiesterases
  • peptidases
  • hydrolase
  • lyases

Published Papers

There is no accepted submissions to this special issue at this moment.
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