Human Carbonic Anhydrase Family as Target for Drug Design
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 478
Special Issue Editors
Interests: structural biology; X-ray crystallography; proteins; protein-ligand complexes
Special Issues, Collections and Topics in MDPI journals
Interests: structural biology; X-ray crystallography; biochemistry
Special Issues, Collections and Topics in MDPI journals
Interests: structural biology; protein crystallography; drug design; carbonyc anhydrases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human Carbonic Anhydrases (hCAs) are zinc enzymes that act as catalysts in the reversible hydration of carbon dioxide to bicarbonate and proton. Up to now, fifteen isoforms have been identified, which differ in terms of kinetic properties, response to inhibitors, cellular localization and pattern of expression in various tissues. In recent years, these enzymes have become an interesting target for the design of inhibitors or activators with biomedical applications. Indeed, several studies have demonstrated the important roles of hCAs in a variety of physiological processes and showed that abnormal levels and/or activities of these enzymes are often associated with different human diseases such as glaucoma, osteoporosis, neurological disorders, cancer, etc. In this Special Issue, we will summarize the most important results obtained in this field and provide future perspectives for the development of novel drug classes targeting hCAs.
Dr. Vincenzo Alterio
Dr. Anna Di Fiore
Dr. Giuseppina De Simone
Guest Editors
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