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Molecules
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Metabolites from Algae: Discovery, Identification and Bioactive Evaluation
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Metabolites from Algae: Discovery, Identification and Bioactive Evaluation

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 7246

Special Issue Editors

Dr. Giovanna Romano

E-Mail Website
Guest Editor
Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Naples, Italy
Interests: novel bioactive metabolites from marine microalgae for pharmaceutical, nutraceutical and cosmeceutical applications; novel strategies to enhance industrial production of marine-derived compounds
Special Issues, Collections and Topics in MDPI journals
Dr. Angela Sardo

E-Mail Website
Guest Editor
Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Naples, Italy
Interests: employment of microalgae for drug discovery and drug delivery systems; as food or feed supplements; for bioremediation purposes; novel culture strategies and technologies to increase the yields of marine primary and secondary metabolites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Marine organisms are an attractive source of metabolites that can be exploited for various biotechnological purposes, including pharmaceutical, nutraceutical and cosmeceutical applications. Among them, macro- and microalgae are considered as an economic, viable and underexploited source of bioactive compounds with health-promoting properties. These organisms can be easily collected from aquatic environments and maintained on laboratory and prototype scales. Their ease of collection and/or cultivation makes them excellent test-organisms for laboratory studies, allows the scale-up of the cultivation processes at pre-industrial and industrial scales, and paves the way for possible concrete applications for the production of specific metabolites of vegetal origin.

Current studies of macro- and microalgae should also be aimed at discovering new methodologies and new technologies to enhance the production on the industrial scale of their metabolites.

In the above context, this Special Issue invites original scientific contributions on topics including:

  • Research articles on novel metabolites from algae with potential applications in drug discovery or as drug delivery systems
  • New strategies to optimize the yields of bioactive metabolites
  • Review articles representing the state of the art on the potential of macro- and/or microalgae as sources of drugs and other valuable compounds.

Dr. Giovanna Romano
Dr. Angela Sardo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine algae-derived metabolites
  • marine photosynthetic organisms as source of drugs, nutraceuticals, cosmeceuticals
  • biotechnological applications of macro- and microalgae
  • novel strategies for industrial production of marine-derived compounds

Published Papers (2 papers)

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Research

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17 pages, 6125 KiB  
Article
Exploring Exogenous Indole-3-acetic Acid’s Effect on the Growth and Biochemical Profiles of Synechocystis sp. PAK13 and Chlorella variabilis
by Wael A. Fathy, Hamada AbdElgawad, Amr H. Hashem, Ehab Essawy, Eman Tawfik, Abdulaziz A. Al-Askar, Mohamed S. Abdelhameed, Ola Hammouda and Khaled N. M. Elsayed
Molecules 2023, 28(14), 5501; https://doi.org/10.3390/molecules28145501 - 19 Jul 2023
Viewed by 1132
Abstract
Microalgae have garnered scientific interest for their potential to produce bioactive compounds. However, the large-scale industrial utilization of microalgae faces challenges related to production costs and achieving optimal growth conditions. Thus, this study aimed to investigate the potential role of exogenous indole-3-acetic acid [...] Read more.
Microalgae have garnered scientific interest for their potential to produce bioactive compounds. However, the large-scale industrial utilization of microalgae faces challenges related to production costs and achieving optimal growth conditions. Thus, this study aimed to investigate the potential role of exogenous indole-3-acetic acid (IAA) application in improving the growth and production of bioactive metabolites in microalgae. To this end, the study employed different concentrations of exogenously administered IAA ranging from 0.36 µM to 5.69 µM to assess its influence on the growth and biochemical composition of Synechocystis and Chlorella. IAA exposure significantly increased IAA levels in both strains. Consequentially, improved biomass accumulation in parallel with increased total pigment content by approximately eleven-fold in both strains was observed. Furthermore, the application of IAA stimulated the accumulation of primary metabolites. Sugar levels were augmented, providing a carbon source that facilitated amino acid and fatty acid biosynthesis. As a result, amino acid levels were enhanced as well, leading to a 1.55-fold increase in total amino acid content in Synechocystis and a 1.42-fold increase in Chlorella. Total fatty acids content increased by 1.92-fold in Synechocystis and by 2.16-fold in Chlorella. Overall, the study demonstrated the effectiveness of exogenously adding IAA as a strategy for enhancing the accumulation of microalgae biomass and biomolecules. These findings contribute to the advancement of microalgae-based technologies, opening new avenues to produce economically important compounds derived from microalgae. Full article
(This article belongs to the Special Issue Metabolites from Algae: Discovery, Identification and Bioactive Evaluation)
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Review

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36 pages, 4730 KiB  
Review
Highly Valuable Polyunsaturated Fatty Acids from Microalgae: Strategies to Improve Their Yields and Their Potential Exploitation in Aquaculture
by Anna Santin, Monia Teresa Russo, Maria Immacolata Ferrante, Sergio Balzano, Ida Orefice and Angela Sardo
Molecules 2021, 26(24), 7697; https://doi.org/10.3390/molecules26247697 - 20 Dec 2021
Cited by 21 | Viewed by 5213
Abstract
Microalgae have a great potential for the production of healthy food and feed supplements. Their ability to convert carbon into high-value compounds and to be cultured in large scale without interfering with crop cultivation makes these photosynthetic microorganisms promising for the sustainable production [...] Read more.
Microalgae have a great potential for the production of healthy food and feed supplements. Their ability to convert carbon into high-value compounds and to be cultured in large scale without interfering with crop cultivation makes these photosynthetic microorganisms promising for the sustainable production of lipids. In particular, microalgae represent an alternative source of polyunsaturated fatty acids (PUFAs), whose consumption is related to various health benefits for humans and animals. In recent years, several strategies to improve PUFAs’ production in microalgae have been investigated. Such strategies include selecting the best performing species and strains and the optimization of culturing conditions, with special emphasis on the different cultivation systems and the effect of different abiotic factors on PUFAs’ accumulation in microalgae. Moreover, developments and results obtained through the most modern genetic and metabolic engineering techniques are described, focusing on the strategies that lead to an increased lipid production or an altered PUFAs’ profile. Additionally, we provide an overview of biotechnological applications of PUFAs derived from microalgae as safe and sustainable organisms, such as aquafeed and food ingredients, and of the main techniques (and their related issues) for PUFAs’ extraction and purification from microalgal biomass. Full article
(This article belongs to the Special Issue Metabolites from Algae: Discovery, Identification and Bioactive Evaluation)
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