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Advances in Nanomedicine and Nano-Based Drug Delivery System
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Advances in Nanomedicine and Nano-Based Drug Delivery System

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 3069

Special Issue Editor

Dr. Hu Hao

E-Mail Website
Guest Editor
Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China
Interests: nano-based drug delivery; hydrogel; sequential administration; cancer therapy; wound treatment

Special Issue Information

Dear Colleagues,

Nanomedicine is defined as the application of the principles and methods of nanoscience and technology to medicine. Nano-based drug delivery systems with nanomaterials as the carrier are becoming a new favorite in the pharmaceutical field. The development formula of nano-carriers includes polymer nanoparticles, micelles, liposomes, dendrimers, metal nanoparticles, etc. Nano-based drug delivery systems possess characteristics such as a large specific surface area, high surface reactivity, multiple active centers, and strong adsorption capacity. Consequently, using nano-carriers can improve the absorption and utilization of drugs, realize efficient target delivery, prolong drug consumption half-life, and reduce harmful side effects on normal tissues. Nano-based drug delivery systems have played an active role in the diagnosis and treatment of many life-threatening diseases, including cancer, cardiovascular diseases, diabetes, AIDS, Alzheimer's disease, Parkinson's disease, and various inflammatory and infectious diseases.

This Special Issue devoted to the advances in nanomedicine and nano-based drug delivery systems will collect communications, research articles, and high-quality review papers. We welcome papers discussing the synthesis of functional macromolecules, preparation of inorganic nanomaterials, construction of nanocomposites, structure–function correlation, and advanced applications. We hope that these joint efforts will provide profound guidelines for the development of nanomedicine and nano-based drug delivery systems.

Dr. Hu Hao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomedicine
  • nano-based drug delivery
  • nanoparticle
  • organic-inorganic composite
  • nanocomposite hydrogel
  • cancer therapy
  • COVID-19 treatment
  • wound treatment

Published Papers (4 papers)

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Research

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12 pages, 4814 KiB  
Article
UV-Triggered Drug Release from Mesoporous Titanium Nanoparticles Loaded with Berberine Hydrochloride: Enhanced Antibacterial Activity
by Fanjiao Zuo, Boyao Wang, Lizhi Wang, Jun He and Xilong Qiu
Molecules 2024, 29(7), 1607; https://doi.org/10.3390/molecules29071607 - 03 Apr 2024
Viewed by 476
Abstract
Mesoporous titanium nanoparticles (MTN) have always been a concern and are considered to have great potential for overcoming antibiotic-resistant bacteria. In our study, MTN modified with functionalized UV-responsive ethylene imine polymer (PEI) was synthesized. The characterization of all products was performed by different [...] Read more.
Mesoporous titanium nanoparticles (MTN) have always been a concern and are considered to have great potential for overcoming antibiotic-resistant bacteria. In our study, MTN modified with functionalized UV-responsive ethylene imine polymer (PEI) was synthesized. The characterization of all products was performed by different analyses, including SEM, TEM, FT-IR, TGA, XRD, XPS, and N2 adsorption-desorption isotherms. The typical antibacterial drug berberine hydrochloride (BH) was encapsulated in MTN-PEI. The process exhibited a high drug loading capacity (22.71 ± 1.12%) and encapsulation rate (46.56 ± 0.52%) due to its high specific surface area of 238.43 m2/g. Moreover, UV-controlled drug release was achieved by utilizing the photocatalytic performance of MTN. The antibacterial effect of BH@MTN-PEI was investigated, which showed that it could be controlled to release BH and achieve a corresponding antibacterial effect by UV illumination for different lengths of time, with bacterial lethality reaching 37.76% after only 8 min of irradiation. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the nanoparticles have also been studied. The MIC of BH@MTN-PEI was confirmed as 1 mg/mL against Escherichia coli (E. coli), at which the growth of bacteria was completely inhibited during 24 h and the concentration of 5 mg/mL for BH@MTN-PEI was regarded as MBC against E. coli. Although this proof-of-concept study is far from a real-life application, it provides a possible route to the discovery and application of antimicrobial drugs. Full article
(This article belongs to the Special Issue Advances in Nanomedicine and Nano-Based Drug Delivery System)
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16 pages, 3425 KiB  
Article
Co-Delivery of Gemcitabine and Honokiol by Lipid Bilayer-Coated Mesoporous Silica Nanoparticles Enhances Pancreatic Cancer Therapy via Targeting Depletion of Tumor Stroma
by Dan Liu, Linjiang Wang, Henan Li, Dong Li, Jianwen Zhou, Jing Wang, Qi Zhang and Defu Cai
Molecules 2024, 29(3), 675; https://doi.org/10.3390/molecules29030675 - 31 Jan 2024
Viewed by 749
Abstract
Syndecan-1 (SDC1) modified lipid bilayer (LB)-coated mesoporous silica nanoparticles (MSN) to co-deliver gemcitabine (GEM) and honokiol (HNK) were prepared for the targeting treatment of pancreatic cancer. The encapsulation efficiencies of GEM and HNK in SDC1-LB-MSN-GEM/HNK were determined to be 60.3 ± 3.2% and [...] Read more.
Syndecan-1 (SDC1) modified lipid bilayer (LB)-coated mesoporous silica nanoparticles (MSN) to co-deliver gemcitabine (GEM) and honokiol (HNK) were prepared for the targeting treatment of pancreatic cancer. The encapsulation efficiencies of GEM and HNK in SDC1-LB-MSN-GEM/HNK were determined to be 60.3 ± 3.2% and 73.0 ± 1.1%. The targeting efficiency of SDC1-LB-MSN-GEM/HNK was investigated in BxPC-3 cells in vitro. The fluorescence intensity in the cells treated with SDC1-LB-MSN-Cou6 was 2-fold of LB-MSN-Cou6-treated cells, which was caused by SDC1/IGF1R-mediated endocytosis. As anticipated, its cytotoxicity was significantly increased. Furthermore, the mechanism was verified that SDC1-LB-MSN-HNK induced tumor cell apoptosis through the mitochondrial apoptosis pathway. Finally, the biodistribution, tumor growth inhibition, and preliminary safety studies were performed on BALB/c nude mice bearing BxPC-3 tumor models. The tumor growth inhibition index of SDC1-LB-MSN-GEM/HNK was 56.19%, which was 1.45-fold and 1.33-fold higher than that of the free GEM/HNK and LB-MSN-GEM/HNK treatment groups, respectively. As a result, SDC1-LB-MSN-GEM/HNK combined advantages of both GEM and HNK and simultaneously targeted and eliminated pancreatic cancerous and cancer-associated stromal cells. In summary, the present study demonstrated a new strategy of synergistic GEM and HNK to enhance the therapeutic effect of pancreatic cancer via the targeting depletion of tumor stroma. Full article
(This article belongs to the Special Issue Advances in Nanomedicine and Nano-Based Drug Delivery System)
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11 pages, 3326 KiB  
Article
A Photocurable Polysaccharide-Based Hydrogel Delivery of Polydeoxyribonucleotide-Loaded Vectors for Wound Treatment
by Zonghui Li, Xiaojun Ma, Qiang Gao, Mingxin Zhang and Hao Hu
Molecules 2023, 28(19), 6788; https://doi.org/10.3390/molecules28196788 - 24 Sep 2023
Viewed by 1132
Abstract
The wounds caused by war, accidents, and diseases require timely and effective treatment. Polysaccharides, as natural macromolecules, have good biocompatibility and unique functions, and are excellent substrates for constructing new wound dressings. Short-chain chitosan (SCS) has good water solubility and, importantly, retains a [...] Read more.
The wounds caused by war, accidents, and diseases require timely and effective treatment. Polysaccharides, as natural macromolecules, have good biocompatibility and unique functions, and are excellent substrates for constructing new wound dressings. Short-chain chitosan (SCS) has good water solubility and, importantly, retains a large number of active amino groups. We first introduce double bonds to SCS. This chitosan derivative can be entangled with sodium alginate (SA) through electrostatic interaction. The flowing sol can be applied to a wound with an irregular shape. Under the initiation of a photoinitiator, the internal double bonds are broken and cross-linked to form a gel. The prepared hydrogel wound dressing exhibited good antibacterial properties and can provide a microenvironment conducive to wound repair. A polydeoxyribonucleotide (PDRN) has been proven to have encouraging therapeutic effects for wound healing. PDRN can be condensed by branched polyethylenimine (PEI) to form a nucleic acid delivery system, which can be efficiently uptaken by cells. The cooperation of hydrogel and nucleic-acid-based therapy presented good results in a mouse full-thickness skin wound model. Full article
(This article belongs to the Special Issue Advances in Nanomedicine and Nano-Based Drug Delivery System)
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28 pages, 7873 KiB  
Review
Advanced Nano-Drug Delivery Systems in the Treatment of Ischemic Stroke
by Jiajie Zhang, Zhong Chen and Qi Chen
Molecules 2024, 29(8), 1848; https://doi.org/10.3390/molecules29081848 - 18 Apr 2024
Viewed by 378
Abstract
In recent years, the frequency of strokes has been on the rise year by year and has become the second leading cause of death around the world, which is characterized by a high mortality rate, high recurrence rate, and high disability rate. Ischemic [...] Read more.
In recent years, the frequency of strokes has been on the rise year by year and has become the second leading cause of death around the world, which is characterized by a high mortality rate, high recurrence rate, and high disability rate. Ischemic strokes account for a large percentage of strokes. A reperfusion injury in ischemic strokes is a complex cascade of oxidative stress, neuroinflammation, immune infiltration, and mitochondrial damage. Conventional treatments are ineffective, and the presence of the blood–brain barrier (BBB) leads to inefficient drug delivery utilization, so researchers are turning their attention to nano-drug delivery systems. Functionalized nano-drug delivery systems have been widely studied and applied to the study of cerebral ischemic diseases due to their favorable biocompatibility, high efficiency, strong specificity, and specific targeting ability. In this paper, we briefly describe the pathological process of reperfusion injuries in strokes and focus on the therapeutic research progress of nano-drug delivery systems in ischemic strokes, aiming to provide certain references to understand the progress of research on nano-drug delivery systems (NDDSs). Full article
(This article belongs to the Special Issue Advances in Nanomedicine and Nano-Based Drug Delivery System)
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