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Organic Chemistry at the Nanoscale: Applications in Nanotechnology and Materials Science

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 321

Special Issue Editor


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Guest Editor
Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via P. Giuria 9, 10125 Torino, Italy
Interests: organic synthesis; surface modification; carbon based nanomaterials; cyclodextrins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With the ever-increasing interest in the development of innovative functionalized nanomaterials, smart nanosystems are being designed, including carbon-based nanomaterials, nanoformulations, polymeric nanostructures and magnetic nanoparticles. Advances in synthetic chemistry and analytics have led to major advances in the field of organic nanomaterials with controlled chemical composition and size distribution. The potential advantages of constructing building blocks using synthetic chemistry at multiple levels have been also exploited for enhancing the surfaces of nanomaterials using either covalent or non-covalent modification, because functionalized nanomaterials may have better physical, chemical and mechanical properties than their non-functionalized counterparts. In this respect, this Special Issue aims to discuss recent progress in the preparation, characterization and applications of multifunctional NMs. Contributions to this Special Issue can be in the form of research articles, short communications and reviews focusing on understanding the role of organic chemistry in obtaining or exploring nanostructured materials. The focus of this Special Issue is on the preparation of organic nanomaterials, new procedures for their functionalization and their application as nanoreactors for organic synthesis.

Dr. Katia Martina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional nanomaterials
  • surfaces and interfaces
  • organic nanomaterials
  • hybrid nanomaterials
  • pharmaceutical application
  • chemo- and biosensors
  • nanoreactors
  • catalysis

Published Papers (1 paper)

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Research

16 pages, 6009 KiB  
Article
Electropositive Citric Acid-Polyethyleneimine Carbon Dots Carrying the PINK1 Gene Regulate ATP-Related Metabolic Dysfunction in APP/PS1-N2a Cells
by Si Yu, Feng Guo, Yuzhen Luo, Xingfang Zhang, Chenyu Wang, Yiheng Liu and Haiying Zhang
Molecules 2024, 29(9), 1907; https://doi.org/10.3390/molecules29091907 - 23 Apr 2024
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Abstract
(1) Background: Alzheimer’s disease (AD) is characterized by β-amyloid (Aβ) peptide accumulation and mitochondrial dysfunction during the early stage of disease. PINK1 regulates the balance between mitochondrial homeostasis and bioenergy supply and demand via the PINK1/Parkin pathway, Na+/Ca2+ exchange, and [...] Read more.
(1) Background: Alzheimer’s disease (AD) is characterized by β-amyloid (Aβ) peptide accumulation and mitochondrial dysfunction during the early stage of disease. PINK1 regulates the balance between mitochondrial homeostasis and bioenergy supply and demand via the PINK1/Parkin pathway, Na+/Ca2+ exchange, and other pathways. (2) Methods: In this study, we synthesized positively charged carbon dots (CA-PEI CDs) using citric acid (CA) and polyethyleneimine (PEI) and used them as vectors to express PINK1 genes in the APP/PS1-N2a cell line to determine mitochondrial function, electron transport chain (ETC) activity, and ATP-related metabolomics. (3) Results: Our findings showed that the CA-PEI CDs exhibit the characteristics of photoluminescence, low toxicity, and concentrated DNA. They are ideal biological carriers for gene delivery. PINK1 overexpression significantly increased the mitochondrial membrane potential in APP/PS1-N2a cells and reduced reactive-oxygen-species generation and Aβ1-40 and Aβ1-42 levels. An increase in the activity of NADH ubiquinone oxidoreductase (complex I, CI) and cytochrome C oxidase (complex IV, CIV) induces the oxidative phosphorylation of mitochondria, increasing ATP generation. (4) Conclusions: These findings indicate that the PINK gene can alleviate AD by increasing bioenergetic metabolism, reducing Aβ1-40 and Aβ1-42, and increasing ATP production. Full article
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