Special Issue "Elucidating Helicobacter pylori and Campylobacter jejuni Attachment Mechanisms"
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 243
Interests: mechanisms of Helicobacter pylori adhesion to the human gastric epithelium; development of new reporter systems for detection of sensitisation with allergen-specific IgE; molecular Immunology
Special Issues, Collections and Topics in MDPI journals
Helicobacter pylori and Campylobacter jejuni are two Gram-negative bacteria with a similar morphology but occupying very distinct environmental niches. The environments are radically different in terms of pH range and the presence of enzymes and other antibacterial factors, as well as the properties of the tissues, such as the composition of mucus. Therefore, both microorganisms have developed distinct survival strategies specific to their environment. However, both pathogens need to colonize the gastrointestinal epithelium in order to ensure their survival in the host.
In recent years, a growing number of adhesins mediating attachment of H. pylori to the gastric mucosa or mucus have been characterized structurally and in terms of their natural ligands (e.g., BabA, SabA, LabA, and HopQ). While the identification of C. jejuni adhesins so far has identified adhesins enabling binding to fibronectin (e.g., FlpA, CadF), most known ligands for H. pylori are carbohydrates, e.g., Lewis B for BabA and sialyl-Lewis X for SabA, with the exception of HopQ, whose ligands are members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family.
However, proteomic and genomic studies have also identified the existence of fibronectin binding adhesins in H. pylori, which remain poorly characterized, and the identity of the ligands for several putative adhesins in C. jejuni is still unknown.
This suggests that in spite of the marked differences, there may also be similarities between the two microorganisms in terms of the adhesins and their ligand specificity.
The aim of this Special Edition is to summarize the status quo of our knowledge regarding adhesins and corresponding ligands by highlighting differences and perhaps similarities between the two bacteria.
Prof. Dr. Franco H. Falcone
Prof. Dr. Andreas Hensel
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