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Micromachines
Special Issues
Molecular Diagnostic Devices and Clinical Applications
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Molecular Diagnostic Devices and Clinical Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 7769

Special Issue Editor

Dr. Yong Shin

E-Mail Website
Guest Editor
Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Institute of Convergence Science and Technology (AMIST), Biomedical Engineering Research Center, Asan Institute for Life Science, Asan Medical Center, 88 Olympicro-43gil, Songpa-gu, Seoul, Korea
Interests: nucleic acid amplification; nanotechnology; sample preparation; biosensors; disease diagnostics

Special Issue Information

Dear Colleagues,

Molecular diagnostics can be considered the optimal form of testing that offers the purposes of biomolecule detection and decision making in clinical applications. Especially, molecular diagnostic devices can be applied in point-of-care testing for medical diagnoses (e.g., pathogen detection, cancer detection and monitoring, etc.) following the combination of sample preparation and detection techniques. This Special Issue aims to promote exchanges of ideas and knowledge about recent molecular diagnostic devices and their clinical applications, focusing on nucleic acid sample preparation, detection techniques, nano-biomaterials, devices, and clinical applications.

This Special Issue includes, but is not limited to, the following:

  • Novel sample preparation techniques and devices;
  • Detection techniques and devices;
  • Optical, chemical, and electrical sensing;
  • Biosensing applications;
  • Clinical applications with the above techniques.

Dr. Yong Shin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Sample preparation
  • Point-of-care testing
  • Biosensors
  • Nano-biomaterials
  • Microfluidics

Published Papers (2 papers)

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Research

12 pages, 1942 KiB  
Article
Multi-Sample Preparation Assay for Isolation of Nucleic Acids Using Bio-Silica with Syringe Filters
by Geun Su Noh, Huifang Liu, Myoung Gyu Kim, Zhen Qiao, Yoon Ok Jang and Yong Shin
Micromachines 2020, 11(9), 823; https://doi.org/10.3390/mi11090823 - 30 Aug 2020
Cited by 2 | Viewed by 2452
Abstract
The spin-column system for the isolation of nucleic acids (NAs) from multiple samples presents the inconvenience of repeated experimentation, time-consumption, and the risk of contamination in the process of the spin-column exchange. Herein, we propose a convenient and universal assay that can be [...] Read more.
The spin-column system for the isolation of nucleic acids (NAs) from multiple samples presents the inconvenience of repeated experimentation, time-consumption, and the risk of contamination in the process of the spin-column exchange. Herein, we propose a convenient and universal assay that can be used to diagnose multiple pathogens using a multi-sample preparation assay. The multi-sample preparation assay combines a 96-well filter/membrane plate, a bio-micromaterial lattice-like micro amine-functional diatomaceous earth (D-APDMS), and homobifunctional imidoesters (HI) for the processing of pathogen enrichment and extraction for multiple samples simultaneously. The purity and quantity of the extracted NAs from pathogens (E. coli and Brucella) using the proposed assay is superior to that of the commercialized spin-column kit. The assay also does not require the replacement of several collection tubes during the reaction processing. For the multi-sample testing, we used as many as six samples simultaneously with the proposed assay. This assay can simultaneously separate up to 96 NAs from one plate, and the use of multichannel pipettes allows faster and simpler experimentation. Therefore, we believe it is a convenient and easy process, and can be easily integrated with other detection methods for clinical diagnostics. Full article
(This article belongs to the Special Issue Molecular Diagnostic Devices and Clinical Applications)
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11 pages, 2960 KiB  
Article
A Simple and Rapid Fungal DNA Isolation Assay Based on ZnO Nanoparticles for the Diagnosis of Invasive Aspergillosis
by Zhen Qiao, Huifang Liu, Geun Su Noh, Bonhan Koo, Qingshuang Zou, Kyusik Yun, Yoon Ok Jang, Sung-Han Kim and Yong Shin
Micromachines 2020, 11(5), 515; https://doi.org/10.3390/mi11050515 - 19 May 2020
Cited by 6 | Viewed by 5062
Abstract
Invasive aspergillosis (IA) is an important cause of morbidity and mortality among immunocompromised people. Imaging and specimen tests used in the clinical diagnosis of aspergillosis with weak and indistinct defects leads to delay in the treatment of early aspergillosis patients. The developing molecular [...] Read more.
Invasive aspergillosis (IA) is an important cause of morbidity and mortality among immunocompromised people. Imaging and specimen tests used in the clinical diagnosis of aspergillosis with weak and indistinct defects leads to delay in the treatment of early aspergillosis patients. The developing molecular techniques provide a new method for the aspergillosis diagnosis. However, the existing methods are complex, time-consuming and may even be potentially hazardous. In this study, we developed a simple and rapid Aspergillus fumigatus spores DNA isolation assay using synthesized zinc oxide (ZnO). ZnO nanoparticles were used to take the place of the traditional commercial lysis buffer. The quality and quantity of the extracted DNA were sufficient for further diagnostics with polymerase chain reaction (PCR) analysis. This method offers easy, green, and economic alternative DNA isolation for the diagnosis of invasive aspergillosis. Full article
(This article belongs to the Special Issue Molecular Diagnostic Devices and Clinical Applications)
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