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Micromachines
Special Issues
Microparticle Fabrication and Its Biomedical Application
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Microparticle Fabrication and Its Biomedical Application

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B3: Nanoparticles in Biomedicine".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 8164

Special Issue Editors

Dr. Yunjin Jeong

E-Mail Website
Guest Editor
Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Republic of Korea
Interests: microparticle; diagnostics; microfluidics; biomicrofluidics; biosensing; bio-micro-electro-mechanical systems (BioMEMS); organs on a chips
Dr. Amos Chungwon Lee

E-Mail Website
Guest Editor
Bio-MAX Institute, Seoul National University, Seoul 08826, Korea
Interests: single cell analysis; spatial omics; circulating tumor cells; DNA-based data storage; DNA nanotechnology; microfabrication
Dr. Sudeok Kim

E-Mail Website
Guest Editor
Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Korea
Interests: lab on a chip; micro/nano fabrication; cell-based assay; high-throughput screening; translational research

Special Issue Information

Dear Colleagues,

Microparticles serve as tools for many biological applications, including diagnosis, treatment, transplantation, actuation, environmental monitoring, molecule handling, and molecule storage. Microparticles have single or multiple functions corresponding to special materials or structures. Those functions can be passive or activated by external forces derived from magnetic, electric, optic, or chemical stimulation. Functionalized microparticles have performed various roles as passive or active micromachines in biological applications. Still, there is potential to develop new methods to prepare functionalized microparticles and find new applications to solve real-world problems using functionalized microparticles, which consist of natural and/or synthetic materials. The micro- or nanostructures that enable the special properties of microparticles can be fabricated by top-down or bottom-up approaches, such as Batch emulsions, microfluidic emulsions, lithography, and electrohydrodynamic spraying. Using these various methods, the microparticle is endowed with various functions, which can be penetrated and handled easily in parallel. This Special Issue will highlight methods to prepare microparticles and applications of functionalized microparticles. We encourage potential authors to propose (1) novel materials and the design and fabrication of micro- or smaller particles in the bioengineering field and (2) new approaches applying micro- or smaller particles to biological applications.

Dr. Yunjin Jeong
Dr. Amos Chungwon Lee
Dr. Sudeok Kim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microparticles in bioengineering
  • particle-based assay
  • microcarrier
  • functionalized microparticle

Published Papers (3 papers)

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Research

10 pages, 2231 KiB  
Article
Anti-Counterfeiting Tags Using Flexible Substrate with Gradient Micropatterning of Silver Nanowires
by Hyeli Kim, Goomin Kwon, Cheolheon Park, Jungmok You and Wook Park
Micromachines 2022, 13(2), 168; https://doi.org/10.3390/mi13020168 - 22 Jan 2022
Cited by 3 | Viewed by 3236
Abstract
Anti-counterfeiting technologies for small products are being developed. We present an anti-counterfeiting tag, a grayscale pattern of silver nanowires (AgNWs) on a flexible substrate. The anti-counterfeiting tag that is observable with a thermal imaging camera was fabricated using the characteristics of silver nanowires [...] Read more.
Anti-counterfeiting technologies for small products are being developed. We present an anti-counterfeiting tag, a grayscale pattern of silver nanowires (AgNWs) on a flexible substrate. The anti-counterfeiting tag that is observable with a thermal imaging camera was fabricated using the characteristics of silver nanowires with high visible light transmittance and high infrared emissivity. AgNWs were patterned at microscale via a maskless lithography method using UV dicing tape with UV patterns. By attaching and detaching an AgNW coated glass slide and UV dicing tape irradiated with multiple levels of UV, we obtained AgNW patterns with four or more grayscales. Peel tests confirmed that the adhesive strength of the UV dicing tape varied according to the amount of UV irradiation, and electrical resistance and IR image intensity measurements confirmed that the pattern obtained using this tape has multi-level AgNW concentrations. When applied for anti-counterfeiting, the gradient-concentration AgNW micropattern could contain more information than a single-concentration micropattern. In addition, the gradient AgNW micropattern could be transferred to a flexible polymer substrate using a simple method and then attached to various surfaces for use as an anti-counterfeiting tag. Full article
(This article belongs to the Special Issue Microparticle Fabrication and Its Biomedical Application)
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13 pages, 2498 KiB  
Article
New Ultrasensitive Sandwich-Type Immunoassay of Dendritic Tri-Fan Blade-like PdAuCu Nanoparticles/Amine-Functionalized Graphene Oxide for Label-Free Detection of Carcinoembryonic Antigen
by Pingping Xu, Wenpo Feng, Mei Wang, Ling Zhang, Gaofeng Liang and Aihua Jing
Micromachines 2021, 12(10), 1256; https://doi.org/10.3390/mi12101256 - 16 Oct 2021
Cited by 5 | Viewed by 1870
Abstract
The early detection of tumor markers has an effective role in the treatment of cancer. Here, a new sandwich-type electrochemical immunosensor for early label-free detection of the cancer biomarker carcinoembryonic antigen (CEA) was developed. Dendritic tri-fan blade-like PdAuCu nanoparticles (PdAuCu NPs)/amine functionalized graphene [...] Read more.
The early detection of tumor markers has an effective role in the treatment of cancer. Here, a new sandwich-type electrochemical immunosensor for early label-free detection of the cancer biomarker carcinoembryonic antigen (CEA) was developed. Dendritic tri-fan blade-like PdAuCu nanoparticles (PdAuCu NPs)/amine functionalized graphene oxide (NH2-GO) were the label of secondary antibodies (Ab2), and Au nanoparticle-decorated polydopamines (Au/PDA) were immobilized on a screen-printed carbon electrode (SPCE) as the substrate materials. Dendritic tri-fan blade-like PdAuCu NPs/NH2-GO was synthesized according to a simple hydrothermal procedure and used to immobilize antibodies (Ab2) with large surfaces areas, increased catalytic properties and good adsorption to amplify the current signals. Subsequently, Ab2/PdAuCu NPs/NH2-GO catalyzed the reduction of H2O2 in the sandwich-type immunoreactions. Under optimal conditions, the immunosensor exhibited a satisfactory response to CEA with a limit detection of 0.07 pg mL−1 and a linear detection range from 0.1 pg mL−1 to 200 ng mL−1. The proposed immunosensor could be suitable enough for a real sample analysis of CEA, and has clinical value in the early diagnosis of cancer. Full article
(This article belongs to the Special Issue Microparticle Fabrication and Its Biomedical Application)
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15 pages, 3790 KiB  
Article
The Fabrication of Amino Acid Incorporated Nanoflowers with Intrinsic Peroxidase-like Activity and Its Application for Efficiently Determining Glutathione with TMB Radical Cation as Indicator
by Ning Jiang, Chuang Zhang, Meng Li, Shuai Li, Zhili Hao, Zhengqiang Li, Zhuofu Wu and Chen Li
Micromachines 2021, 12(9), 1099; https://doi.org/10.3390/mi12091099 - 12 Sep 2021
Cited by 7 | Viewed by 2391
Abstract
The assessment of glutathione (GSH) levels is associated with early diagnostics and pathological analysis for various disorders. Among all kinds of techniques for detecting GSH, the colorimetric assay relying on the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) catalyzed by many nanomaterials with peroxidase-like activity attracts [...] Read more.
The assessment of glutathione (GSH) levels is associated with early diagnostics and pathological analysis for various disorders. Among all kinds of techniques for detecting GSH, the colorimetric assay relying on the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) catalyzed by many nanomaterials with peroxidase-like activity attracts increasing attention owing to its outstanding merits, such as high sensitivity and high selectivity. However, the aggregation between the nanomaterials severely hinders the entrance of TMB into the “active site” of these peroxidase mimics. To address this problem, the D-amino acid incorporated nanoflowers possessing peroxidase-like activity with a diameter of 10–15 μm, TMB and H2O2 were employed to establish the detection system for determining the level of glutathione. The larger diameter size of the hybrid nanoflowers substantially averts the aggregation between them. The results confirm that the hybrid nanoflowers detection system presents a low limit of detection, wide linear range, perfect selectivity, good storage stability and desired operational stability for the detection of GSH relying on the intrinsic peroxidase-like activity and favorable mechanical stability of the hybrid nanoflowers, indicating that the hybrid nanoflowers detection system has tremendous application potential in clinical diagnosis and treatment. Full article
(This article belongs to the Special Issue Microparticle Fabrication and Its Biomedical Application)
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