Wearable Microneedle Sensors for Healthcare

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 1762

Special Issue Editor

Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Interests: construction of multi-parameter sensor array and its application in health diagnosis and treatment; application of functionalized nanomaterials in environmental pollution detection
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Special Issue Information

Dear Colleagues,

The rapid development of wearable sensors provides cost-effective and portable measurement tools to improve or replace traditional laboratory diagnostic techniques. Among them, wearable sensors based on microneedles have attracted much more attention because of their minimally invasive characteristics and great potential in detecting various analytes. Traditional injection and analytical sampling commonly use metal needles, which not only easily bring pain and fear to patients, but also present a risk of infection at the site of insertion. The small size, painlessness, and portability of wearable microneedle-based sensors have shown promising application in both sampling and in situ detection, such as transdermal sampling, drug delivery, and physiological marker sensing. A common goal of wearable microneedle sensors is to protect and improve human health, whether through tissue fluid samples or direct health diagnosis. Representative examples include, but are not limited to, microneedles for transdermal sampling, wearable microneedle sensors for transdermal detection, wearable microneedles for transdermal drug delivery, and multifunctional wearable microneedle-based systems. Therefore, this Special Issue seeks to showcase articles and reviews that focus on the latest results and findings in wearable microneedle sensors and their applications in healthcare.

We look forward to receiving your submissions!

Dr. Ning Tang
Guest Editor

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Keywords

  • microneedles
  • wearable technology
  • healthcare
  • transdermal sampling
  • diagnosis and treatment

Published Papers (1 paper)

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Research

7 pages, 1893 KiB  
Communication
Facile Fabrication of Silk Fibroin/Off-Stoichiometry Thiol-Ene (OSTE) Microneedle Array Patches
by Yuqian Yang, Zhiqing Xiao, Lexin Sun, Zitao Feng, Zejingqiu Chen and Weijin Guo
Micromachines 2023, 14(2), 388; https://doi.org/10.3390/mi14020388 - 4 Feb 2023
Viewed by 1440
Abstract
Microneedles have been used in various applications in biomedical engineering, including drug delivery, biosensing, and vaccine delivery. In this study, we develop a novel protocol to fabricate silk fibroin/off-stoichiometry thiol-ene (OSTE) hybrid microneedle array patches. Silk fibroin, as a natural biomaterial, has been [...] Read more.
Microneedles have been used in various applications in biomedical engineering, including drug delivery, biosensing, and vaccine delivery. In this study, we develop a novel protocol to fabricate silk fibroin/off-stoichiometry thiol-ene (OSTE) hybrid microneedle array patches. Silk fibroin, as a natural biomaterial, has been proven to be suitable as a drug carrier. Firstly, drug (we use insulin in this experiment) dissolved in silk fibroin solution is deposited on a microneedle mold and dried thoroughly. After that, silk fibroin needle tips are formed on the OSTE base by replica molding. We investigated the influence of the silk fibroin concentration on the length of silk needle tips and found that the silk concentration had a small influence on the tip length. We also tested the mechanical strength of the microneedles by inserting them into gelatin gel for dummy drug delivery tests. Such composite structures have the potential to increase the delivery efficiency by delivering the whole silk tip into the dermis. Full article
(This article belongs to the Special Issue Wearable Microneedle Sensors for Healthcare)
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