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Micromachines
Special Issues
Microfluidics and 3D Printing for Biomedical Applications
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Microfluidics and 3D Printing for Biomedical Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "D3: 3D Printing and Additive Manufacturing".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 903

Special Issue Editors

Dr. Gokhan Bahcecioglu

E-Mail Website
Guest Editor
Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA
Interests: tissue engineering; bioprinting; cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Bradley Ellis

E-Mail Website
Guest Editor Assistant
Department of Surgery, Harvard Medical School, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, 51 Blossom Street, Boston, MA 02114, USA
Interests: cardiac tissue engineering; hepatic tissue engineering; microfluidics; endothelial cells
Dr. Gozde Basara

E-Mail Website
Guest Editor Assistant
Harvard Medical School Wyss Institute, Boston, MA 02215, USA
Interests: cardiac tissue engineering; bioprinting

Special Issue Information

Dear Colleagues,

Microfluidics and 3D printing are two promising microfabrication techniques that have recently gained attention in the biomedical field because of their reliability, precision, and wide range of applications. Microfluidics allows for the fabrication of microscale tissue and disease models that can be used to test drug responses recapitulating human clinical conditions. Three-dimensional printing provides spatial and temporal control on the type, concentration, and distribution of cells, signaling molecules, and materials, enabling the construction of functional tissues and disease models with high precision and complexity. These two techniques make it possible to create a 3D microenvironment for the cells to mimic cell–cell and cell–material interactions in the body, which are essential for tissue-level maturity and functionality.

This Special Issue seeks to showcase research papers and review articles that focus on the tissue engineering applications of microfluidics and 3D printing, including organs-on-chips, tissue engineering scaffolds, disease models, and drug testing platforms.

Dr. Gokhan Bahcecioglu
Guest Editor

Dr. Bradley Ellis
Dr. Gozde Basara
Guest Editor Assistants

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D printing
  • bioprinting
  • microfluidics
  • organs-on-chips
  • functional tissues
  • disease modeling

Published Papers (1 paper)

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Research

25 pages, 10664 KiB  
Article
Coaxial 3D Bioprinting Process Research and Performance Tests on Vascular Scaffolds
by Jiarun Sun, Youping Gong, Manli Xu, Huipeng Chen, Huifeng Shao and Rougang Zhou
Micromachines 2024, 15(4), 463; https://doi.org/10.3390/mi15040463 - 29 Mar 2024
Viewed by 677
Abstract
Three-dimensionally printed vascularized tissue, which is suitable for treating human cardiovascular diseases, should possess excellent biocompatibility, mechanical performance, and the structure of complex vascular networks. In this paper, we propose a method for fabricating vascularized tissue based on coaxial 3D bioprinting technology combined [...] Read more.
Three-dimensionally printed vascularized tissue, which is suitable for treating human cardiovascular diseases, should possess excellent biocompatibility, mechanical performance, and the structure of complex vascular networks. In this paper, we propose a method for fabricating vascularized tissue based on coaxial 3D bioprinting technology combined with the mold method. Sodium alginate (SA) solution was chosen as the bioink material, while the cross-linking agent was a calcium chloride (CaCl2) solution. To obtain the optimal parameters for the fabrication of vascular scaffolds, we first formulated theoretical models of a coaxial jet and a vascular network. Subsequently, we conducted a simulation analysis to obtain preliminary process parameters. Based on the aforementioned research, experiments of vascular scaffold fabrication based on the coaxial jet model and experiments of vascular network fabrication were carried out. Finally, we optimized various parameters, such as the flow rate of internal and external solutions, bioink concentration, and cross-linking agent concentration. The performance tests showed that the fabricated vascular scaffolds had levels of satisfactory degradability, water absorption, and mechanical properties that meet the requirements for practical applications. Cellular experiments with stained samples demonstrated satisfactory proliferation of human umbilical vein endothelial cells (HUVECs) within the vascular scaffold over a seven-day period, observed under a fluorescent inverted microscope. The cells showed good biocompatibility with the vascular scaffold. The above results indicate that the fabricated vascular structure initially meet the requirements of vascular scaffolds. Full article
(This article belongs to the Special Issue Microfluidics and 3D Printing for Biomedical Applications)
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