Special Issue "Climate Change and Marine Natural Products"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 May 2020) | Viewed by 4069

Special Issue Editors

Department of Drug Discovery, Medical University of South Carolina, Charleston, SC 29425, USA
Interests: marine natural products chemistry; infectious diseases; cancer; spectroscopy; drug discovery and development
Special Issues, Collections and Topics in MDPI journals
Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA
Interests: natural products; medicinal plants; GI microbiome

Special Issue Information

Dear Colleagues,

Since the 1950s, a growing number of secondary metabolites have been characterized from marine invertebrates, plants, algae, and microbes, which has provided a vast array of structural diversity and potential drug leads. However, the diversity of the oceans and coral reef communities in general is challenged like no other as a product of climate change. At the same time, climate change is having a growing influence in the emergence of a variety of human health issues. Of course, the recent Nobel Prizes awarded to William Campbell, Satoshi Omura, and Tu Youyou for their pioneering work in the development of treatments for roundworm parasites and malaria emphasize the significance of natural product discoveries in the control of emerging diseases.

In this Special Issue of Marine Drugs, we are encouraging investigators to provide preliminary communications, expert opinions, research papers, and reviews covering the impact that climate change is having and will have on the future of emerging diseases, marine species diversity, drug discovery, and human health. In this compilation of papers, we will also assess the impact climate change is having on the marine environment, human health, and our ability of react with new chemical entities from the oceans. We would also encourage contributions that assess climate change and the impact climate change is having on both marine biodiversity as well as the global prevalence of emerging diseases.

Prof. Mark Hamann
Dr. Xiaoyan Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • marine therapeutics and species diversity
  • climate change and its impact on the oceans
  • tropical neglected diseases
  • drug discovery and development
  • natural products synthesis
  • methodologies in natural products discovery
  • climate change and emerging diseases

Published Papers (1 paper)

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22 pages, 1911 KiB  
Comparative Analysis of the Soluble Proteome and the Cytolytic Activity of Unbleached and Bleached Millepora complanata (“Fire Coral”) from the Mexican Caribbean
Mar. Drugs 2019, 17(7), 393; https://doi.org/10.3390/md17070393 - 03 Jul 2019
Cited by 7 | Viewed by 3745
Coral bleaching caused by global warming has resulted in massive damage to coral reefs worldwide. Studies addressing the consequences of elevated temperature have focused on organisms of the class Anthozoa, and up to now, there is little information regarding the mechanisms by which [...] Read more.
Coral bleaching caused by global warming has resulted in massive damage to coral reefs worldwide. Studies addressing the consequences of elevated temperature have focused on organisms of the class Anthozoa, and up to now, there is little information regarding the mechanisms by which reef forming Hydrozoans face thermal stress. In this study, we carried out a comparative analysis of the soluble proteome and the cytolytic activity of unbleached and bleached Millepora complanata (“fire coral”) that inhabited reef colonies exposed to the 2015–2016 El Niño-Southern Oscillation in the Mexican Caribbean. A differential proteomic response involving proteins implicated in key cellular processes, such as glycolysis, DNA repair, stress response, calcium homeostasis, exocytosis, and cytoskeleton organization was found in bleached hydrocorals. Four of the proteins, whose levels increased in bleached specimens, displayed sequence similarity to a phospholipase A2, an astacin-like metalloprotease, and two pore forming toxins. However, a protein, which displayed sequence similarity to a calcium-independent phospholipase A2, showed lower levels in bleached cnidarians. Accordingly, the hemolytic effect of the soluble proteome of bleached hydrocorals was significantly higher, whereas the phospholipase A2 activity was significantly reduced. Our results suggest that bleached M. complanata is capable of increasing its toxins production in order to balance the lack of nutrients supplied by its symbionts. Full article
(This article belongs to the Special Issue Climate Change and Marine Natural Products)
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