Halogenated Metabolites
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (15 April 2019) | Viewed by 3395
Special Issue Editors
Interests: chemistry of natural and microbial products; fungal and bacterial endophytes; secondary metabolites, marine natural products; genome mining; structural characterization; metabolomics; molecular networking
Special Issues, Collections and Topics in MDPI journals
Interests: natural products chemistry; metabolomics; bioactivity; marine fungi; halogenated secondary metabolites; mass spectrometry; bioinformatics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Halogens are abundant components of Earth’s biosphere and a huge diversity of organohalides ranging from single-carbon methylhalides to structurally far more complex compounds such as palau’amine are produced by living organisms.
The incorporation of halogens into organic molecules usually involves halogenating enzymes which are widely distributed among prokaryotic and eukaryotic organisms such as macroalgae, bacteria or fungi. Accordingly, a huge diversity of species is able to produce organohalides in both terrestrial and marine environments.
Chlorination is predominant, followed by bromination, while iodination and fluorination are rarer in Nature. In addition, while chlorinated compounds are quite ubiquitous in terrestrial environments, brominated compounds are mostly isolated from marine species. In such marine environment, these halogenated compounds are responsible for important biological functions ranging from chemical defense to signaling molecules. As a result, they also display potential application in human therapeutics.
The biogenesis of these compounds has intrigued scientists for decades and more recently, conserved DNA sequence motifs of various halogenases have been successfully exploited for the identification of new halogenated metabolites, as well as for cloning gene clusters that encodes the halogenated metabolites production.
Accordingly, in this Special Issue of Marine Drugs, we would like to cover different recent aspects related to naturally occurring halogenated compounds such as their detection in marine environments, their structural characterization, their biosynthesis and bioengineering, their ecological roles as well as their bioactivity. Consequently, we cordially welcome colleagues to contribute to this Special Issue with reviews, original papers, or short communications.
Prof. Soizic Prado
Dr. Catherine Roullier
Guest Editors
Manuscript Submission Information
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Keywords
- Halogenated marine secondary metabolites
- Ecological roles
- Metabolomic studies
- Bioengineering
- Genome Mining
