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Marine Drugs
Special Issues
Nutraceuticals and Pharmaceuticals from Marine Fish and Invertebrates II
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Nutraceuticals and Pharmaceuticals from Marine Fish and Invertebrates II

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 12300

Special Issue Editor

Prof. Dr. Vida Šimat

E-Mail Website
Guest Editor
Department of Marine Studies, University of Split, R. Boškovića 37, 21000 Split, Croatia
Interests: food quality and safety; food technology; seafood; fatty acids; seaweed antioxidans; marine bioactives
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the continuous search for sustainable natural sources of bioactive compounds for the food and pharmaceutical industries, marine organisms, comprising approximately one-half of the global biodiversity, are one of the most important and recently investigated bio-resources. Bioactive compounds isolated from marine micro and macroalgae, animals, and microorganisms are considered a safe and environmentally friendly alternative to existing synthetic nutraceuticals and pharmaceuticals. In this Special Issue of Marine Drugs, you are invited to submit recent advances in research of the bioactive compounds from marine fish and invertebrates (both wild-caught and cultured) and their by-products, including enzymes, pigments, peptides, proteins, essential fatty acids (particularly eicosapentaenoic and docosahexaenoic acid), vitamins, and minerals, their chemistry and biological activity, as well as innovations in their production/extraction and application as nutraceuticals, therapeutic agents and pharmaceuticals. We also welcome research on the role of these components in protecting human health, standardization of these compounds through studies and trials, research on safety, purity, and dosage of the ingredients in commercial products and the development of new nutraceuticals, therapeutic agents, and pharmaceuticals.

Prof. Dr. Vida Šimat
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine fish and invertebrates
  • Extraction method
  • Bioactive peptides
  • Biological activity
  • Mechanism of action
  • Food application
  • Therapeutic effect
  • Enzyme inhibitors
  • Novel marine compounds

Published Papers (2 papers)

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Research

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22 pages, 1772 KiB  
Article
Diversity and Antimicrobial Activity of Vietnamese Sponge-Associated Bacteria
by Ton That Huu Dat, Nguyen Thi Kim Cuc, Pham Viet Cuong, Hauke Smidt and Detmer Sipkema
Mar. Drugs 2021, 19(7), 353; https://doi.org/10.3390/md19070353 - 22 Jun 2021
Cited by 20 | Viewed by 3517
Abstract
This study aimed to assess the diversity and antimicrobial activity of cultivable bacteria associated with Vietnamese sponges. In total, 460 bacterial isolates were obtained from 18 marine sponges. Of these, 58.3% belonged to Proteobacteria, 16.5% to Actinobacteria, 18.0% to Firmicutes, [...] Read more.
This study aimed to assess the diversity and antimicrobial activity of cultivable bacteria associated with Vietnamese sponges. In total, 460 bacterial isolates were obtained from 18 marine sponges. Of these, 58.3% belonged to Proteobacteria, 16.5% to Actinobacteria, 18.0% to Firmicutes, and 7.2% to Bacteroidetes. At the genus level, isolated strains belonged to 55 genera, of which several genera, such as Bacillus, Pseudovibrio, Ruegeria, Vibrio, and Streptomyces, were the most predominant. Culture media influenced the cultivable bacterial composition, whereas, from different sponge species, similar cultivable bacteria were recovered. Interestingly, there was little overlap of bacterial composition associated with sponges when the taxa isolated were compared to cultivation-independent data. Subsequent antimicrobial assays showed that 90 isolated strains exhibited antimicrobial activity against at least one of seven indicator microorganisms. From the culture broth of the isolated strain with the strongest activity (Bacillus sp. M1_CRV_171), four secondary metabolites were isolated and identified, including cyclo(L-Pro-L-Tyr) (1), macrolactin A (2), macrolactin H (3), and 15,17-epoxy-16-hydroxy macrolactin A (4). Of these, compounds 2-4 exhibited antimicrobial activity against a broad spectrum of reference microorganisms. Full article
(This article belongs to the Special Issue Nutraceuticals and Pharmaceuticals from Marine Fish and Invertebrates II)
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Review

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38 pages, 6727 KiB  
Review
Bioactive Compounds from Marine Sponges: Fundamentals and Applications
by Disha Varijakzhan, Jiun-Yan Loh, Wai-Sum Yap, Khatijah Yusoff, Rabiha Seboussi, Swee-Hua Erin Lim, Kok-Song Lai and Chou-Min Chong
Mar. Drugs 2021, 19(5), 246; https://doi.org/10.3390/md19050246 - 27 Apr 2021
Cited by 48 | Viewed by 8207
Abstract
Marine sponges are sessile invertebrates that can be found in temperate, polar and tropical regions. They are known to be major contributors of bioactive compounds, which are discovered in and extracted from the marine environment. The compounds extracted from these sponges are known [...] Read more.
Marine sponges are sessile invertebrates that can be found in temperate, polar and tropical regions. They are known to be major contributors of bioactive compounds, which are discovered in and extracted from the marine environment. The compounds extracted from these sponges are known to exhibit various bioactivities, such as antimicrobial, antitumor and general cytotoxicity. For example, various compounds isolated from Theonella swinhoei have showcased various bioactivities, such as those that are antibacterial, antiviral and antifungal. In this review, we discuss bioactive compounds that have been identified from marine sponges that showcase the ability to act as antibacterial, antiviral, anti-malarial and antifungal agents against human pathogens and fish pathogens in the aquaculture industry. Moreover, the application of such compounds as antimicrobial agents in other veterinary commodities, such as poultry, cattle farming and domesticated cats, is discussed, along with a brief discussion regarding the mode of action of these compounds on the targeted sites in various pathogens. The bioactivity of the compounds discussed in this review is focused mainly on compounds that have been identified between 2000 and 2020 and includes the novel compounds discovered from 2018 to 2021. Full article
(This article belongs to the Special Issue Nutraceuticals and Pharmaceuticals from Marine Fish and Invertebrates II)
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